Synthesis and characterization of a novel pH-controllable composite hydrogel for anticancer drug delivery

Anirudhan, T.S.; Sandeep, S.

doi:10.1039/c1nj20672a

Cited by 28 publications

(14 citation statements)

References 22 publications

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“…In high-pH medium (7.4), the hydrophilic groups(-OH) on the composite were getting ionised and the electrostatic repulsion between these negative charges led to the high swelling of the composite; however, in acidic medium, the absence of swelling caused the collapse of AMCD-g-APTSB. Similar results were reported by Anirudhan and Sandeep [31].…”

Section: Synthesis Of the Composite And Characterizationsupporting

confidence: 92%

“…The encapsulation efficiency of the composite depends on the amount of the monomers, cross-linking agent and also the pH of the medium. Acrylamido-2methylpropane sulfonic acid grafted N-maleoylchitosan intercalated montmorillonite showed encapsulation efficiency of 94% [31] whereas alginate/chitosan-coated mesoporous silica-based nanocarriers showed a value of 85.7% [36]. The AMCD-g-APSB (present study) showed higher encapsulation efficiency of 96.1% compared with other mesoporous silica materials.…”

Section: Synthesis Of the Composite And Characterizationmentioning

confidence: 82%

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A Green Approach for the Synthesis of Drug Delivery System, Mesoporous Silica Grafted Acrylamide –Β- Cyclodextrin Composite, for the Controlled Release of Curcumin

Mullassery

Fernandez

Surya

et al. 2018

Asian J Pharm Clin Res

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Objective:The scope of the present study was the preparation and characterization of a novel composite acrylamide β-cyclodextrin grafted 3-aminopropyltriethoxysilane bentonite (AMCD-g-APSB), for the controlled delivery of curcumin (CUR).Methods: AMCD-g-APSB, was synthesized by solvent-free conditions using microwave irradiation. The structure and surface morphology of the composite was established using Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, thermal analysis, etc. Results:The swelling percentage of the composite depends on both time and pH of the medium. The maximum swelling of the composite occurred at a pH of 7.4. The maximum drug encapsulation was occurring at a pH 3. About 96.5% of drug was loaded at pH 3. In vitro biocompatibility study was performed, and the result showed good biocompatibility of the composite in the concentration range 2.5-50 μg/ml. Conclusions:Drug delivery study of the composite proved that CUR could be successfully released in a controlled manner in the colon without much loses of the drug in the stomach.

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Section: Synthesis Of the Composite And Characterizationsupporting

confidence: 92%

Section: Synthesis Of the Composite And Characterizationmentioning

confidence: 82%

A Green Approach for the Synthesis of Drug Delivery System, Mesoporous Silica Grafted Acrylamide –Β- Cyclodextrin Composite, for the Controlled Release of Curcumin

Mullassery

Fernandez

Surya

et al. 2018

Asian J Pharm Clin Res

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“…90 Iron oxide (Fe 3 O 4 ) was covered with carboxymethyl chitosan (CMCS), 90 in which montmorillonite (MMT) was intercalated to enhance cellular uptake of the NPs. 90, 91 A lipophilic fluorescent dye, coumarin-6, was covalently intercalated to MMT to label the CMCS/MMT-covered MNPs for a cellular uptake study. 90, 92 Flow cytometry was used in quantifying the uptake of the coumarin-6 labeled CMCS/MMT-MNPs by HeLa cells.…”

Section: Cell-based Evaluation Of Npsmentioning

confidence: 99%

Nanoparticle Characterization: State of the Art, Challenges, and Emerging Technologies

et al. 2013

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Nanoparticles have received enormous attention as a promising tool to enhance target-specific drug delivery and diagnosis. Various in vitro and in vivo techniques are used to characterize a new system and predict its clinical efficacy. These techniques enable efficient comparison across nanoparticles and facilitate a product optimization process. On the other hand, we recognize their limitations as a prediction tool, which owe to inadequate applications and overly simplified test conditions. This article provides a critical review of in vitro and in vivo techniques currently used for evaluation of nanoparticles and introduces emerging techniques and models that may be used complementarily.

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“…125 The pHresponsiveness of hydrogels is usually attributed to their ionic groups. In particular, montmorillonite 126 and LAPONITE s127 are more or less pH-dependent due to the edge charges. The addition of these clay minerals can increase the ionization of polymers, following a chain expansion in response to pH.…”

Section: Stimuli-responsivenessmentioning

confidence: 99%

Recent advances in clay mineral-containing nanocomposite hydrogels

et al. 2015

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Clay mineral-containing nanocomposite hydrogels have been proven to have exceptional composition, properties, and applications, and consequently have attracted a significant amount of research effort over the past few years. The objective of this paper is to summarize and evaluate scientific advances in clay mineral-containing nanocomposite hydrogels in terms of their specific preparation, formation mechanisms, properties, and applications, and to identify the prevailing challenges and future directions in the field. The state-of-the-art of existing technologies and insights into the exfoliation of layered clay minerals, in particular montmorillonite and LAPONITE s , are discussed first. The formation and structural characteristics of polymer/clay nanocomposite hydrogels made from in situ free radical polymerization, supramolecular assembly, and freezing-thawing cycles are then examined. Studies indicate that additional hydrogen bonding, electrostatic interactions, coordination bonds, hydrophobic interaction, and even covalent bonds could occur between the clay mineral nanoplatelets and polymer chains, thereby leading to the formation of unique three-dimensional networks. Accordingly, the hydrogels exhibit exceptional optical and mechanical properties, swelling-deswelling behavior, and stimuli-responsiveness, reflecting the remarkable effects of clay minerals. With the pivotal roles of clay minerals in clay mineral-containing nanocomposite hydrogels, the nanocomposite hydrogels possess great potential as superabsorbents, drug vehicles, tissue scaffolds, wound dressing, and biosensors. Future studies should lay emphasis on the formation mechanisms with in-depth insights into interfacial interactions, the tactical functionalization of clay minerals and polymers for desired properties, and expanding of their applications.

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Synthesis and characterization of a novel pH-controllable composite hydrogel for anticancer drug delivery

Cited by 28 publications

References 22 publications

A Green Approach for the Synthesis of Drug Delivery System, Mesoporous Silica Grafted Acrylamide –Β- Cyclodextrin Composite, for the Controlled Release of Curcumin

A Green Approach for the Synthesis of Drug Delivery System, Mesoporous Silica Grafted Acrylamide –Β- Cyclodextrin Composite, for the Controlled Release of Curcumin

Nanoparticle Characterization: State of the Art, Challenges, and Emerging Technologies

Recent advances in clay mineral-containing nanocomposite hydrogels

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