Synthesis and characterization of a novel amphiphilic chitosan?polylactide graft copolymer

Wu, Yan; Zheng, Yang; Yang, Wuli; Wang, Changchun; Hu, Jianhua; Fu, Shoukuan

doi:10.1016/j.carbpol.2004.09.006

Cited by 183 publications

(97 citation statements)

References 18 publications

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“…Copolymers based on lactic acid have been widely used in sutures and pH-sensitive drug release systems because of their biodegradability. Luckachan et al [107] developed chitosan /oligo(L-lactide) graft copolymers by ring opening polymerisation of L-lactide in DMSO at 90°C under a nitrogen atmosphere using Ti(OBu) 4 as catalyst. They obtained a graft copolymer with increased hydrophilicity and controlled degradation rate that may have wide applications in wound dressing and in controlled drug delivery systems.…”

Section: Graft C O P O L Y M E R I Z a T I O Nmentioning

confidence: 99%

Chitosan: The Most Valuable Derivative of Chitin

Nayak¹

2011

Biopolymers

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Section: Graft C O P O L Y M E R I Z a T I O Nmentioning

confidence: 99%

Chitosan: The Most Valuable Derivative of Chitin

Nayak¹

2011

Biopolymers

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“…18,19 When TEA is used as a catalyst, PLLAgrafted chitin/chitosan copolymers can be readily synthesized via ring-opening polymerization. 20,21 Thus, the synthesis of the lactide derivatives of other polysaccharides via this method is anticipated.…”

Section: Introductionmentioning

confidence: 98%

Self‐organized nanogels from pullulan‐g‐poly(L‐lactide) synthesized by one‐pot method: Physicochemical characterization and in vitro doxorubicin release

Cho

Park

2009

J of Applied Polymer Sci

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Water-insoluble pullulan-g-poly(L-lactide) (PUPL) was successfully synthesized via a one-pot method in the presence of triethylamine in dimethyl sulfoxide, in an effort to design a novel anticancer agent carrier. Three samples (designated as PUPL 1, 2, and 3) were obtained, which differed in the moles of lactides grafted to the pullulan. The degrees of grafted lactide per 1 glucose unit in pullulan were 0.68, 0.60, and 0.45 for PUPL 1, 2, and 3, respectively. These copolymers were dissolved in several organic solvents, including dimethyl sulfoxide, acetone, and ethanol, but were insoluble in water. The self-organized nanogels were then prepared from the polymers via dialysis. To study the organizing behavior of the polymers, their critical association concentrations were measured. Their values were 5.0, 15.9, and 52.9 mg/L for PUPL 1, 2, and 3, respectively. The results showed that lactide in the polymers could function as a hydrophobic moiety for the formation of selforganized nanogels. To estimate the potential of PUPL 1 as an anticancer drug carrier, we used doxorubicin (DOX) as a model drug. The DOX loading efficiencies of PUPL 1 were more than 52%, which differed with differing initial DOX concentrations. High loading resulted in slower DOX release as the result of increases in hydrophobic interaction.In conclusion, PUPL nanogels may prove useful as anticancer drug carriers because of their low critical association concentrations and the controlled DOX release rate V

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“…Because the ring-opening polymerization of lactone or lactide may be initialized easily by the hydroxyl group when the catalyst was used, many researchers have utilized this method to prepare polyester grafted polysaccharides, for example, starch, [13][14][15][16][17][18] pullulan, 19,20 dextran, [21][22][23][24][25][26] and chitosan. [27][28][29] Poly (vinyl alcohol) (PVA) could also be esterified by the same reaction both in bulk 30 and in solution. 31 Polyester grafted PVA, PVA-graft-poly(lactic-co-glycolic acid) (PVA-g-PLGA), for example, exhibits a faster in vitro degradation rate than the PLGA homopolymer.…”

Section: Introductionmentioning

confidence: 98%

In vitro degradation of biodegradable blending materials based on poly(p‐dioxanone) and poly(vinyl alcohol)‐graft‐poly(p‐dioxanone) with high molecular weights

Chen

Wang

et al. 2006

J Biomedical Materials Res

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Amphiphilic biodegradable graft copolymer, poly(vinyl alcohol)-graft-poly(p-dioxanone) (PVA-g-PPDO), was used to prepare a new biodegradable material by blending with poly(p-dioxanone) (PPDO). The in vitro degradation properties of the copolymer and blends with different contents of PVA-g-PPDO were studied in phosphate buffer at 37 degrees C. The degradation processes of the PVA-g-PPDO and its blends with the PPDO were monitored by weight loss, viscosimetry, water uptake, differential scanning calorimetry (DSC), and scanning electron microscopy. The results of inherent viscosity and weight loss reveal that the PVA-g-PPDO has a different in vitro degradation behavior from that of PPDO, and the introducing of copolymer into the blending system may enhance the degradability of PPDO when the contents of copolymer is higher than 5%. The change of the degree of crystallization (Dc) of copolymer and blends derived from the DSC also shows that the copolymer and blends have faster degradation rates than the neat PPDO during the testing period. A degradation mechanism of the blends was postulated based on the results of the weight retention, inherent viscosity measurement, and DSC.

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Synthesis and characterization of a novel amphiphilic chitosan?polylactide graft copolymer

Cited by 183 publications

References 18 publications

Chitosan: The Most Valuable Derivative of Chitin

Chitosan: The Most Valuable Derivative of Chitin

Self‐organized nanogels from pullulan‐g‐poly(L‐lactide) synthesized by one‐pot method: Physicochemical characterization and in vitro doxorubicin release

In vitro degradation of biodegradable blending materials based on poly(p‐dioxanone) and poly(vinyl alcohol)‐graft‐poly(p‐dioxanone) with high molecular weights

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