Synthesis and characterization of a series of achiral and chiral mono- and bis[(dien)Pt(II)I]I derivatives as potential DNA and RNA structure probes and anticancer drugs

Sulfonamide Ligands from Chiral Aziridines − Application to the Titanium-Mediated Addition of Diethylzinc to Benzaldehyde

“…[43,52Ϫ54] Reaction of 3 equiv. of the aziridine with ammonia yields C 3symmetric tris(sulfonamides), [44] but the reactions can be stopped after the introduction of merely 1 [55] or 2 equiv. of the aziridine, and thus afford mono-as well as bis(sulfonamides) (Scheme 2).…”

“…of the aziridine, provided that a large excess of amine was used. [55] Thus, the reaction using an excess of benzylamine (9.5 equiv.) resulted in the mono-and bis(adducts) 8 and 2 in a ratio of 10:1.…”

A General Method for the Preparation of Chiral TREN Derivatives

“…Deprotection of compounds containing several N-sulfonyl functions has occasionally been connected with problems. [25] In our previous procedure we employed N-nosylaziridines. [26] Deprotection was achieved using mercaptoacetic acid and LiOH, [27] thiophenol and sodium carbonate, [27] or sodium in ammonia.…”

Crystal and Molecular Structure of a Potential DNA Groove-Spanning Chelate: [MV][Pt2(hdta)Cl2]·4H2O (MV2+ = 1,1‘-Dimethyl-4,4‘-bipyridinium, hdta4- = 1,6-Hexanediamine-N,N,N‘,N‘-tetraacetate)

“…Cisplatin-like binuclear complexes with two metal binding units connected by an organic tether may be important drugs to overcome acquired resistance and repair pathways which limit cisplatin mononuclear derivatives in antitumor action. − Their advantage lies in the formation of interstrand DNA cross-links using N-7 attachments at GG sequences, predominantly. − It is believed that the tether across the major groove disrupts the binding of repair proteins and proteins utilized for DNA polymerase activity, promoting cytoxicity. Binuclear lesions of DNA may also promote suicide adducts with repair proteins which deplete tumor cells of repair capacity …”