Synthesis and Characterization of a New Mebendazole Salt: Mebendazole Hydrochloride

Tautomerism in drugs with benzimidazole carbamate moiety: an electronic structure analysis

“…They also reported that a polymorph of albendazole with C tautomer is relatively more preferable, over a polymorph with B tautomer for albendazole. Mebendazole is known to exist in three polymorphic forms (A, B, and C), with polymorph C being most efficacious [19,68,69]. Polymorph B is reported to be toxic.…”

“…Low aqueous solubility (\6 mg/mL) of these molecules has restricted their formulation development in the forms of suspensions, paste, powder, or intraruminal bolus, which compels the administration in larger doses to achieve the desired therapeutic response [16][17][18][19][20]. Solid-state researchers working in the molecular pharmaceutics are fascinated to understand the polymorphism in the BC molecules, so as to improve the bioavailability profile of these molecules.…”

Intermolecular contacts influencing the conformational and geometric features of the pharmaceutically preferred mebendazole polymorph C

“…Complete crystal structure data of MBZ polymorphs are not found in the literature because single crystals seem to be hard to obtain. In an attempt to obtain adequate crystals for single crystal X‐ray diffraction we have recently reported a new stable salt, mebendazole hydrochloride which was also fully characterized by structural, vibrational and thermal analysis 14…”

Mebendazole crystal forms in tablet formulations. An ATR-FTIR/chemometrics approach to polymorph assignment

“…Therefore, some derivatives, such as the hydrochloride salt [9], and crystal engineering [10] alternatives have been recently proposed to promote polymorph conversion or improve drug solubility and bioavailability.…”