Synthesis and characterization of a novel polymeric hydrogel based on hydroxypropyl methyl cellulose grafted with polyacrylamide

Abstract

A novel hydrogel has synthesized by grafting polyacrylamide chains onto hydroxypropyl methylcellulose in presence of potassium persulphate as initiator using solution polymerization technique. The reaction was carried out in homogeneous aqueous medium. The effect of reaction parameters on percentage of grafting (% G) and grafting efficiency (% GE) were discussed. The parameters were varied systematically to achieve the best hydrogel. Developed hydrogels were characterized by various materials characterization techniques. The dynamic and equilibrium swelling properties of hydrogels were investigated as a function of pH and time in various buffer solutions similar to that of gastric and intestinal fluid. Results showed that with increase in % G and % GE, the rate of swelling decreases, which can opens the door for further study of their utilization as matrices for controlled/sustained/targeted drug delivery.

Novel pH-responsive graft copolymer based on HPMC and poly(acrylamide) synthesised by microwave irradiation: application in controlled release of ornidazole

“…For comparison, g-HPMC (C) was also synthesised by conventional heating as reported earlier (Das et al 2012).…”

“…The detailed procedure for measurement of equilibrium swelling and deswelling parameters was followed as reported before (Das et al 2012(Das et al , 2013 and is given in the Supplementary Information.…”

“…Additionally, the molecular weight of synthesised graft copolymers rose with the increase of % GE. This is because the higher the % GE is, the longer the presence of grafted chains, which increase the hydrodynamic volume of the copolymer in solution, resulting in a higher apparent molecular weight (Das et al 2012). Also, the MWI-based optimised graft copolymer [i.e.…”

“…1. All the peaks responsible for HPMC (Das et al 2012) are present in g-HPMC 6 (M) (see Table S1, Supplementary Information). Additionally, the graft copolymer showed two extra absorption bands at 1,660 and 1,588 cm -1 , which are responsible for the amide-I and amide-II bands of the grafted PAAm chains (Table S1, Supplementary Information).…”

“…Free radicals are generally created in several ways. The initiators are commonly used for conventional grafting method (Das et al 2012). Synthesis through microwave irradiation (MWI) is the simplest and fastest synthetic tool for a rapid and energy-efficient process using selective dielectric heating.…”