Synthesis and Characterization of Alginate Scaffolds Containing Bioactive Glass for Bone Tissue Engineering Applications

Zamani, Delaram; Razmjooee, Kavoos; Moztarzadeh, F.; Bizari, Davood

doi:10.1109/icbme.2017.8430220

Cited by 3 publications

(1 citation statement)

References 12 publications

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“…Alginate is a natural biopolymer that obtains from brown algae and consists of 1,4-linked β-D-mannuronic acid (M) and α-L-guluronic acid (G) units [36]. Alginate has excellent biocompatibility, biodegradability, non-toxicity, and nonimmunogenicity [37]. Alginate can be crosslinked via divalent cations or other polymers to prepare wound dressings [38,39] and absorbs excess exudates to maintain a suitable moist environment at the wound surface [40].…”

Section: Introductionmentioning

confidence: 99%

Carboxymethyl chitosan–alginate hydrogel containing GSNO with the ability to nitric oxide release for diabetic wound healing

et al. 2022

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Today, despite significant progress in developing skin tissue engineering products, the fabrication of an ideal wound dressing that could meet the essential criteria, such as promoting angiogenesis -mainly in a diabetic wound- still remains a challenge. A diabetic wound is a chronic wound in which vascularization is low, and the wound healing process may stop. In this regard, Nitric oxide (NO) enhances the healing of diabetic wounds by promoting angiogenesis and providing antibacterial activity in wound sites. In this study, we produced a NO-releasing wound dressing (CMC-ALg-GSNO) composed of Carboxymethyl chitosan (CMC), sodium alginate (ALg), and Snitrosoglutathione (GSNO). The results obtained from the scanning electron microscopy (SEM) show that wound dressing has a porous structure. The water uptake and water vapor transmission for the wound dressing were obtained 4354.1 ± 179.3 % and 2753.8 ± 54.6 g/m2 per day, respectively. NO release study showed that NO release from CMC-ALg-GSNO continuously occurred within 168 hours. In vivo test, The CMC-ALg-GSNO wound dressing developed wound healing in a rat model of full-thickness diabetic wounds compared to the CMC-ALg and Gauze wound dressings. Thus, this study showed that CMC-ALg-GSNO wound dressing could lead to novel therapeutic invasions to treat diabetic wounds.

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