Synthesis and characterization of amine modified magnetite nanoparticles as carriers of curcumin-anticancer drug

Sundar, Sasikala; Mariappan, R.; Piraman, Shakkthivel

doi:10.1016/j.powtec.2014.06.033

Cited by 82 publications

(31 citation statements)

References 34 publications

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“…Secondly, all of the samples have also shown the fingerprint zones of chitosan and APTES at several positions on the spectrum. The presence of Si-O-Si and Si-O-C bands at 1144 and 1110 cm −1 confirms the presence of APTES and also demonstrates the inter-linkages occurring between the Si-O and C moieties of both graphene and chitosan, respectively [41][42][43][44][45]. …”

Section: Raman Spectroscopysupporting

confidence: 57%

Study on the Effect of Silanization and Improvement in the Tensile Behavior of Graphene-Chitosan-Composite

et al. 2015

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Abstract:In the present study, silane-functionalized graphene (f-graphene)-reinforced chitosan nanocomposite films exhibiting enhanced mechanical properties have been prepared by the solution casting method. These nanocomposite films were characterized by X-ray diffraction, Raman spectroscopy and thermogravimetric analysis. In order to investigate the effect of silane functionalization, tensile tests were performed on original, oxidized and silane-functionalized graphene-reinforced chitosan nanocomposite films. Tensile results show that silane functionalization groups offer a substantial increase in the interfacial adhesion between filler and host matrix. This result is also confirmed by the surface morphology of the fracture surface in scanning electron microscope analysis. Qualitative analysis using Raman and Fourier transform infrared spectroscopy revealed the existence of Si-O-Si and Si-O-C bonds in the silanized composite. Thermal analysis of the samples shows that the material is stable up till 250 °C and maintains its thermal stability all throughout the process until it starts degrading after 510 °C. Atomic force microscopy reveals that the material is well exfoliated after the oxidation of graphene and also displays the existence of 3-6 layers of exfoliated graphene sheets. X-ray photoelectron spectroscopy studies also reveal the existence of silicon in the single state and quantify the sample to be approximately around 4% (±0.5%) of the total atomic weight. OPEN ACCESSPolymers 2015, 7 528

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Section: Raman Spectroscopysupporting

confidence: 57%

Study on the Effect of Silanization and Improvement in the Tensile Behavior of Graphene-Chitosan-Composite

et al. 2015

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“…Crocin conjugation efficiency was determined by an indirect method involving detection of total free crocin concentration in the decanted solutions by measuring the absorbance at 440 nm (visible range) using a Uv-visible spectrophotometer. The amounts of crocin coating on MNPs were calculated from the difference between the total amount of crocin initially used to coat MNPs and the amount of free crocin present in the decanted solutions (14).…”

Section: Methodsmentioning

confidence: 99%

Development of a therapeutic model of precancerous liver using crocin-coated magnetite nanoparticles

El-Kharrag

Amin

Hisaindee

et al. 2016

International Journal of Oncology

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Despite considerable advances in understanding hepatocellular carcinoma, it is one of the common and deadliest cancers worldwide. Hence, increasing efforts are needed for early diagnosis and effective treatments. Saffron has been recently found to inhibit growth of liver cancer in rats. The aim of this study was to develop an effective method for treatment of liver cancer using magnetite nanoparticles (MNPs) coated with crocin, the main active component of saffron. MNPs were prepared and initially coated with dextran and a cross-linker to enhance conjugation of crocin using a modified coprecipitation method. Cultured HepG2 cells and diethylnitrosamine-injected mice were treated with corcin-coated MNPs and analyzed using cell proliferation assay and immunohistochemical analysis, respectively. Treatment of HepG2 cells with crocin-coated MNPs led to a significant inhibition of their growth as compared to control or those treated with free crocin or uncoated MNPs. Histological examinations of the livers of diethylnitrosamine-injected mice revealed several precancerous changes: multiple proliferative hepatic foci, hyper- or dysplastic transformations of bile ducts/ductules, and nuclear atypia associated with polyploidy, karyomegaly, and vacuolation. Immunohistochemistry using antibodies specific for cell proliferation (Ki-67) and apoptosis (M30-CytoDEATH and Bcl-2) revealed their upregulation during development of precancerous lesions. Using antibodies specific for inflammation (cyclooxygenase-2), oxidative stress (glutathione) and angiogenesis (vascular endothelial growth factor) indicated the involvement of multiple signaling pathways in the development of precancerous lesions. Treatment with crocin-coated MNPs was associated with regression of precancerous lesions, significant upregulation of apoptotic cells and downregulation of Bcl-2 labeling and markers of cell proliferation, inflammation, oxidative stress and angiogenesis. In conclusion, crocin-coated MNPs are more effective than free corcin for treatment of liver precancerous lesions in mice. These findings will help to develop new modalities for early detection and treatment of liver precancerous lesions.

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“…Curcumin (principal curcuminoid of spice turmeric) with two other compounds like desmethoxycurcumin and bis-desmethoxycurcumin) [8][9][10] exhibit a keto-enol tautomerism [11,12] and therefore have diverce reactivity. Its daily application as condiment and spice has chemopreventive and chemotherapeutic which candidate it for treatment of ailments such as lung cancer, skin and liver diseases [13][14][15]. Various role including antioxidant, anti-inflammatory, antibacterial, antiviral, anti-atherosclerotic, anti-arthriticagent and anticancer activities [16][17][18][19] are logical reasons for its extensive application and encourage researchers to design an accurate approach for preconcentration and quantification of curcumin in low level in complicated matrices.…”

Section: Introductionmentioning

confidence: 99%

A highly selective nanocomposite based on MIP for curcumin trace levels quantification in food samples and human plasma following optimization by central composite design

Bahrani

Mansoorkhani

Ostovan

2017

Journal of Chromatography B

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Synthesis and characterization of amine modified magnetite nanoparticles as carriers of curcumin-anticancer drug

Cited by 82 publications

References 34 publications

Study on the Effect of Silanization and Improvement in the Tensile Behavior of Graphene-Chitosan-Composite

Study on the Effect of Silanization and Improvement in the Tensile Behavior of Graphene-Chitosan-Composite

Development of a therapeutic model of precancerous liver using crocin-coated magnetite nanoparticles

A highly selective nanocomposite based on MIP for curcumin trace levels quantification in food samples and human plasma following optimization by central composite design

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