Synthesis and characterization of amino acid-functionalized hydroxyapatite nanorods

Gonzalez-McQuire, Rosanna; Chane‐Ching, Jean‐Yves; Vignaud, E.; Lebugle, A.; Mann, Stephen

doi:10.1039/b400317a

Cited by 200 publications

(167 citation statements)

References 18 publications

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“…This is attributed to the ability of these functional groups to attract Ca 2þ and PO 4 32 ions, thus increasing the degree of local supersaturation with respect to calcium phosphate precipitation at regions close to the surfaces [50,53]. While there have been many studies investigating the inhibitory effect of AAs dissolved in solution on HA mineralization [6,[18][19][20][21][22][23][24][25][26][27][28], the effect of AAs bound to surfaces has been subject of just a few studies [8,55,56]. Rautaray et al [8] investigated HA precipitation in the presence of Aspcapped gold nanoparticles (figure 4).…”

Section: Amino Acids Bound To Surfacesmentioning

confidence: 99%

“…AAs dissolved in a solution can either chelate the Ca 2þ and PO 4 32 ions in solution or cover the surface of nascent HA nuclei, thus inhibiting its further growth [6,[18][19][20][21][22][23][24][25][26][27][28]. On the other hand, AAs bound to surfaces are able to promote HA crystallization by attracting Ca 2þ and PO 4 32 ions, thus creating a local supersaturated environment that promotes heterogeneous nucleation of HA [8].…”

Section: In Vitro Studies Of the Effect Of Individual Amino Acids On mentioning

confidence: 99%

“…Interface 13: 20160462 AA/HA surface interactions have been extensively studied [6,15,18 -23,38,39]. In general, AAs show an increase in adsorption to HA surfaces based on the charge of their side groups: apolar (alanine (Ala)) , positively charged (Lys) , polar (Ser) , negatively charged (Asp) [23]. Koutsopoulos & Dalas conducted a number of studies on the affinity of various AAs to HA surfaces [18 -22].…”

Section: (Fix)mentioning

confidence: 99%

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The role of amino acids in hydroxyapatite mineralization

Tavafoghi¹,

Cerruti²

2016

J. R. Soc. Interface.

209

147

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Polar and charged amino acids (AAs) are heavily expressed in noncollagenous proteins (NCPs), and are involved in hydroxyapatite (HA) mineralization in bone. Here, we review what is known on the effect of single AAs on HA precipitation. Negatively charged AAs, such as aspartic acid, glutamic acid (Glu) and phosphoserine are largely expressed in NCPs and play a critical role in controlling HA nucleation and growth. Positively charged ones such as arginine (Arg) or lysine (Lys) are heavily involved in HA nucleation within extracellular matrix proteins such as collagen. Glu, Arg and Lys intake can also increase bone mineral density by stimulating growth hormone production. In vitro studies suggest that the role of AAs in controlling HA precipitation is affected by their mobility. While dissolved AAs are able to inhibit HA precipitation and growth by chelating Ca 2þ and PO 4 32 ions or binding to nuclei of calcium phosphate and preventing their further growth, AAs bound to surfaces can promote HA precipitation by attracting Ca 2þ and PO 4 32 ions and increasing the local supersaturation. Overall, the effect of AAs on HA precipitation is worth being investigated more, especially under conditions closer to the physiological ones, where the presence of other factors such as collagen, mineralization inhibitors, and cells heavily influences HA precipitation. A deeper understanding of the role of AAs in HA mineralization will increase our fundamental knowledge related to bone formation, and could lead to new therapies to improve bone regeneration in damaged tissues or cure pathological diseases caused by excessive mineralization in tissues such as cartilage, blood vessels and cardiac valves.

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Section: Amino Acids Bound To Surfacesmentioning

confidence: 99%

Section: In Vitro Studies Of the Effect Of Individual Amino Acids On mentioning

confidence: 99%

Section: (Fix)mentioning

confidence: 99%

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The role of amino acids in hydroxyapatite mineralization

Tavafoghi¹,

Cerruti²

2016

J. R. Soc. Interface.

209

147

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“…Various techniques have been developed to prepare nanosized hexaferrite for these purposes. They include the glass crystallization method [29], the wet method [30], the liquid mix technique [31], colloidal methods [32], and so on. The common feature of these methods is the intimate mixing of ions in the atomic level so that subsequent nucleation and crystallization can occur and induce the phase transition at relatively low temperatures.…”

Section: Introductionmentioning

confidence: 99%

Development of Radar Absorbing Nano Crystals under Thermal Irradiation

Sharma

Agarwala

2008

JNanoR

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) were synthesized by a modified flux method that combines the controlled chemical co-precipitation process for nucleation and complete uniform growth during in-situ annealing with NaCl flux under vacuum furnace. Uniform structure morphological transformation of nano crystals from spherical to prism faces were noticed after annealing with increasing temperatures from 200 to 1200 o C for 4 h in vacuum. XRD results showed the single phase nanocrystals of BaFe 18 O 27 with increasing crystallanity and size from 10 to 90 nm during annealing. FESEM and TEM were used to investigate the systematic growth processes of various morphologies of nano crystals. The effect of such systematic morphological transformation of nanocrystals was observed in dielectric, dynamic magnetic and refection loss (RL) properties in Kuband (12.4 -18.0 GHz). A significant increment from -15.23 dB to -43.65 dB with wide range of bandwidth in RL loss is noticed due to the symmetric morphological growth of single phase nano crystals of RAM during annealing. This process of crystal growth, morphology evolution and RL enhancement with respect to increasing temperature were also explained in terms of ostwald ripening and quantum size effect. IntroductionThe electromagnetic interference (EMI) problems have been attracting more attention recently due to the extensive growth in the application of electronic devices such as computer local area networks, mobiles phones, laptops, microwave oven etc [1][2][3]. EMI can cause severe interruption on electronically controlled systems. Furthermore, larger exposure to microwave energy can be potentially harmful to biological systems and human beings. To overcome EMI problems, it is suggested that electromagnetic wave absorbing materials with the capability of absorbing unwanted electromagnetic signals are to be used. For significant absorption of electromagnetic waves, the radar absorption material (RAM) should have electric and/or magnetic dipoles that interact with the electromagnetic fields in the radiation. Microwave absorption materials from magnetic to dielectric related materials used in a high frequency are particularly noticed. But, pure dielectric or magnetic materials are insufficient for absorbing radiation energy. The efficiency of magnetic-dielectric absorbers is high because the complex permittivity (ε΄-jε˝) and permeability (µ΄-jµ˝) differ from zero [4][5][6]. In general, the suitable values of RAM can be achieved by adding lossy fillers and/or magnetic particles to a light weight that are physically and chemically stable one and of course have a high ability to absorb electromagnetic wave radiation [7][8][9][10]. The composite approach has been used to improve various material properties, including mechanical, chemical, structural, optical and electrical/magnetic etc [11][12][13][14][15][16][17].

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“…The morphology of HAp nanoparticles can be manipulated by adding template additives (such as surfactant molecules 25,26) and amino acids [27][28][29][30] ). This variation is mainly due to the inhibition of crystal growth from preferential adsorption of the template molecules onto the HAp surface.…”

Section: Discussionmentioning

confidence: 99%

Adsorption and desorption behaviors of cetylpyridinium chloride on hydroxyapatite nanoparticles with different morphologies

et al. 2016

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Application of hydroxyapatite (HAp) nanoparticles to repair damaged enamel has attracted recent attention. In this study, HAp nanoparticles with various morphologies (spherical, short-rod, long-rod and fiber morphologies) were synthesized via chemical precipitation methods without the addition of template molecules, and the adsorption/desorption behaviors of a cationic antibacterial agent, cetylpyridinium chloride (CPC), on the HAp nanoparticles were evaluated. The adsorption of CPC on each HAp nanoparticle showed Langmuir-type adsorption, and the short-rod/long-rod HAp nanoparticles showed thermodynamically more stable adsorption of CPC than that with the spherical/fiber HAp nanoparticles. The desorption rate of CPC from the short-rod/long-rod HAp nanoparticles was slower than that of the spherical/fiber HAp nanoparticles. The HAp nanoparticles with different CPC release profiles presented here have potential applications as nanoparticulate enamel repair agents with antibacterial properties.

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Synthesis and characterization of amino acid-functionalized hydroxyapatite nanorods

Cited by 200 publications

References 18 publications

The role of amino acids in hydroxyapatite mineralization

The role of amino acids in hydroxyapatite mineralization

Development of Radar Absorbing Nano Crystals under Thermal Irradiation

Adsorption and desorption behaviors of cetylpyridinium chloride on hydroxyapatite nanoparticles with different morphologies

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