A copper/Schiff‐base complex supported on amine‐functionalized silica mesoporous magnetic nanoparticles was prepared as novel magnetically interphase nanoparticles and its morphology and structure were evaluated using Fourier transform infrared spectroscopy, X‐ray diffraction, field emission scanning electron microscopy, transmission electron microscopy, energy dispersive X‐ray spectroscopy, thermogravimetric analysis, zeta potential, and a vibrating sample magnetometer. The catalytic activity of the synthesized nanoparticles was evaluated for the synthesis of thiazolidine‐4‐ones.