Synthesis and characterization of antibacterial carboxymethyl Chitosan/ZnO nanocomposite hydrogels

Wahid, Fazli; Yin, Jun-Jiao; Xue, Dong-Dong; Han, Xue; Lu, Yu-Shi; Zhong, Cheng; Chu, Li‐Qiang

doi:10.1016/j.ijbiomac.2016.03.044

Cited by 157 publications

(58 citation statements)

References 51 publications

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“…All microporous scaffolds showed swelling ratios in the range of 13–20. This is much higher than the swelling data of 2–12 for CS films reported by Mirzaei et al . During the first day, the nanocomposite hydrogel scaffolds reached to its maximum swelling ratio and were saturated with the immersed liquid.…”

Section: Resultscontrasting

confidence: 61%

In situsynthesized chitosan–gelatin/ZnO nanocomposite scaffold with drug delivery properties: Higher antibacterial and lower cytotoxicity effects

Rakhshaei

Namazi

Hamishehkar

et al. 2019

J of Applied Polymer Sci

107

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In this work, chitosan–gelatin/zinc oxide nanocomposite hydrogel scaffolds (CS–GEL/nZnO) were prepared via in situ synthesis of ZnO nanoparticles (nZnO) to reach a scaffold with both inherent antibacterial and drug delivery properties. The prepared nanocomposite hydrogel scaffolds were characterized using scanning electron microscopy, transmission electron microscopy, atomic absorption spectrometer, Fourier transform infrared spectroscopy, and X‐ray diffraction. In addition, swelling, biodegradation, antibacterial, cytocompatibility, and cell attachment of the scaffolds were evaluated. The results showed that the prepared scaffolds had high porosity with a pore size of 50–400 μm and nZnO were well distributed without any agglomeration on the CS–GEL matrix. In addition, the nanocomposite scaffolds showed enhanced swelling, biodegradation, and antibacterial properties. Moreover, the drug delivery studies using naproxen showed that nZnO could control naproxen release. Cytocompatibility of the samples was proved using normal human dermal fibroblast cells (HFF2). In comparison to the previous reports which nZnO were simply added to the matrix of the scaffold, in situ synthesis of nZnO was led to higher antibacterial and lower cytotoxicity effects as a result of well distribution of nZnO in this method. According to the findings, the in situ synthesized CS–GEL/nZnO is strongly recommended for biomedical applications especially skin tissue engineering. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47590.

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Section: Resultscontrasting

confidence: 61%

In situsynthesized chitosan–gelatin/ZnO nanocomposite scaffold with drug delivery properties: Higher antibacterial and lower cytotoxicity effects

Rakhshaei

Namazi

Hamishehkar

et al. 2019

J of Applied Polymer Sci

107

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“…[103][104][105] CMC and CS hydrogels were also reported to be used as a hydrogel matrix for ZnO NPs. 98,99,106 CMC hydrogels exhibited antibacterial activity against both Gram-positive and Gram-negative bacteria, and CS hydrogels were confirmed eligible wound dressing materials. 103,107,108 Although the antibacterial ability of ZnO NPs is relatively weak, the low cytotoxicity still indicated that ZnO NPs have potential in clinical use.…”

Section: Zinc Oxide Nanoparticles (Zno Nps)mentioning

confidence: 89%

Antimicrobial hydrogels: promising materials for medical application

Yang

Han

Chen

et al. 2018

IJN

317

230

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The rapid emergence of antibiotic resistance in pathogenic microbes is becoming an imminent global public health problem. Local application of antibiotics might be a solution. In local application, materials need to act as the drug delivery system. The drug delivery system should be biodegradable and prolonged antibacterial effect should be provided to satisfy clinical demand. Hydrogel is a promising material for local antibacterial application. Hydrogel refers to a kind of biomaterial synthesized by a water-soluble natural polymer or a synthesized polymer, which turns into gel according to the change in different signals such as temperature, ionic strength, pH, ultraviolet exposure etc. Because of its high hydrophilicity, unique three-dimensional network, fine biocompatibility and cell adhesion, hydrogel is one of the suitable biomaterials for drug delivery in antimicrobial areas. In this review, studies from the past 5 years were reviewed, and several types of antimicrobial hydrogels according to different ingredients, different preparations, different antimicrobial mechanisms, different antimicrobial agents they contained and different applications, were summarized. The hydrogels loaded with metal nanoparticles as a potential method to solve antibiotic resistance were highlighted. Finally, future prospects of development and application of antimicrobial hydrogels are suggested.

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“…The disc diffusion method was performed simply by putting the samples onto the bacteria coated agar plates, and then the zone of inhibition was examined after 24 h . CFU method was performed by counting the viable bacterial colonies as described in the literature . Briefly, the bacterial cells were grown overnight in an Luria‐Bertani (LB) broth medium.…”

Section: Methodsmentioning

confidence: 99%

Facile Incorporation of Silver Nanoparticles into Quaternized Poly(2-(Dimethylamino)Ethyl Methacrylate) Brushes as Bifunctional Antibacterial Coatings

Yin

Wahid

Zhang

et al. 2017

Macromol. Mater. Eng.

Self Cite

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A simple strategy to fabricate bifunctional antibacterial coatings via in situ synthesis and incorporation of silver nanoparticles (AgNPs) into quaternized poly(2‐(dimethylamino)ethyl methacrylate) (qPDMAEMA) brushes without using any reducing agents is reported. PDMAEMA brushes are prepared on Si wafer substrates via surface‐initiated reverse atom transfer radical polymerization, which then are quaternized with ethyl bromide and hexyl bromide, respectively. The resulting qPDMAEMA‐AgNP nanocomposite coatings are characterized by using Fourier‐transform infrared spectroscopy (FT‐IR), X‐ray photoelectron spectroscopy (XPS), field emission scanning electron microscope (FE‐SEM), and Raman spectroscopy. FE‐SEM and Raman results indicate that the AgNPs with an average diameter of 35 nm are successfully loaded into the qPDMAEMA brushes. Furthermore, the antibacterial activities of the qPDMAEMA‐AgNP nanocomposite coatings against Gram‐positive Staphylococcus aureus and Gram‐negative Escherichia coli are investigated by both disc diffusion and colony‐forming unit methods. The results show excellent antibacterial properties of the nanocomposite coatings. The influence of the length of the quaternization agents on their antibacterial properties is also investigated.

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Synthesis and characterization of antibacterial carboxymethyl Chitosan/ZnO nanocomposite hydrogels

Cited by 157 publications

References 51 publications

In situsynthesized chitosan–gelatin/ZnO nanocomposite scaffold with drug delivery properties: Higher antibacterial and lower cytotoxicity effects

In situsynthesized chitosan–gelatin/ZnO nanocomposite scaffold with drug delivery properties: Higher antibacterial and lower cytotoxicity effects

Antimicrobial hydrogels: promising materials for medical application

Facile Incorporation of Silver Nanoparticles into Quaternized Poly(2-(Dimethylamino)Ethyl Methacrylate) Brushes as Bifunctional Antibacterial Coatings

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