Synthesis and Characterization of Antimicrobial Activity of Quinoline Derivatives

Abstract

Quinoline family compounds are widely used as a parent compound to make drugs fungicides, biocides, alkaloids, dyes, rubber, chemicals, flavoring agents, antiseptic. Its derivatives are one of the important constituents of pharmacologically active synthetic compounds such as anti-inflammatory, antimicrobial agents, cytotoxic activity, antidotal, antibacterial and so on. The present work is done to explore the possibility of getting novel antimicrobial agents by linking 3-formyl-6-nitroquinoline-2-thione with various aryl amines to obtain novel Schiff and anti-oxidant activities. Two new targeted Schiff based quinolones (BSAT-1-2) were screened for wound healing activity and antioxidant property by taking standard povidone iodine and ascorbic acid. BSAT-2 shown percentage wound contraction on 16 th day 94%, standard povidone-iodine shown wound contraction on the same day was 87%and control shown less than the BSAT-2 i.e. 84.5% and the percentage inhibition of hydrogen peroxide of BSAT-2 at 125 µg/ml is 66.54% and the reference standard ascorbic acid at same concentration was found to be 43.95%. From the results, it clearly signifies that BSAT-2 is more potent.

Synthesis and Identification of New Azolidine-4-one Derived from Creatinine and Study their Anticancer and Antioxidant Effects

“…The reaction mixture was then refluxed for 7-9 hours before cooling to room temperature. The solid crude material was filtered and recrystallized from ethanol [17]. The physical properties of the title compounds 13-15 are listed in Table 1.…”

Quinoline‐derivatives as privileged scaffolds for medicinal and pharmaceutical chemists: A comprehensive review

“…Firoz et al explored the novel quinolone derivatives and reported that compound 102 , was the most potent one as on 16th day the percentage wound contraction was 94% as compared to the 87%, 84.5% contraction of standard povidone‐iodine and control, respectively. Furthermore, at a concentration of 125 μg/ml this compound with hydrogen peroxide showed more antioxidant activity than the standard ascorbic acid with a percentage inhibition of 66.54% and 43.95%, respectively (Firoz et al, 2017). Savegnago and other coresearcher reported the synthesis and antioxidant activity of novel 4‐arylchalcogenyl‐chloroquinoline analogues.…”

Synthesis and Characterization of some new heterocyclic derivatives from aromatic carbonyl ‎compounds and carboxylic acids with Evaluation some of them for biological activity

“…The 1,2,4-triazole ring has been shown to have a wide range of pharmacological properties, including antibacterial and antifungal properties [19]. Meanwhile, thiazolidine-4one heterocycles exhibit various effects on health such as antimicrobial, antifungal, antitumor, antidiabetic, anti-inflammatory, gastrointestinal issues and several different methods of producing heterocycles through cyclization reactions have been discussed in the medical literature [20][21][22][23][24][25]. For example, thiazoles have been synthesized by cyclization of thiourea with acetic acid under alkaline conditions.…”