Synthesis and Characterization of Bi-Magnetic Core/Shell Nanoparticles for Hyperthermia Applications

Hammad, Mohaned; Nica, Valentin; Hempelmann, Rolf

doi:10.1109/tmag.2016.2635696

Cited by 12 publications

(14 citation statements)

References 28 publications

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“…Dark field transmission electron microscopy (DF-TEM) can be used to discern different compositions based on contrast variations, since this technique predominantly uses Rutherford scattered electrons, which present greater susceptibility to small differences in atomic number (Z) [40]. Therefore, the morphology of the core-shell NPs was studied by DF-TEM, as previously reported [17,41]. The results confirmed the hard/soft magnetic phases of the CF@MF NPs (Figure 3c).…”

Section: Transmission Electron Microscopysupporting

confidence: 75%

“…Fe@MFe 2 O 4 (M=Fe, Mn, Co) core-shell NPs demonstrate higher transverse relaxivity (r 2 ) than their single-core counterpart with similar size [15]. Additionally, bi-magnetic NPs can also be used for drug delivery [16] and magnetic hyperthermia [17], thus being excellent candidates for the development of novel nano-theranostic agents. The use of magnetic hyperthermia for tumor therapy is based on the fact that cancer cells are more sensitive to small increases in temperature than healthy cells.…”

Section: Introductionmentioning

confidence: 99%

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Bi-Magnetic Core-Shell CoFe2O4@MnFe2O4 Nanoparticles for In Vivo Theranostics

et al. 2020

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In this work, we report the synthesis and characterization of three magnetic nanosystems, CoFe2O4, CoFe2O4@ZnFe2O4, and CoFe2O4@MnFe2O4, which were developed as potential theranostic agents for magnetic hyperthermia and magnetic resonance imaging (MRI). These nanosystems have been thoroughly characterized by X-ray Diffraction (XRD), Transmission Electron Miscroscopy (TEM), Dark Field-TEM (DF-TEM), Vibrating Sample Magnetometry (VSM), and inductive heating, in order to elucidate their structure, morphology, and magnetic properties. The bi-magnetic CoFe2O4@ZnFe2O4 and CoFe2O4@MnFe2O4 nanoparticles (NPs) exhibited a core-shell structure with a mean average particle size of 11.2 ± 1.4 nm and 14.4 ± 2.4 nm, respectively. The CoFe2O4@MnFe2O4 NPs showed the highest specific absorption rate (SAR) values (210–320 W/g) upon exposure to an external magnetic field, along with the highest saturation magnetization (Ms). Therefore, they were selected for functionalization with the PEGylated ligand to make them stable in aqueous media. After the functionalization process, the NPs showed high magnetic relaxivity values and very low cytotoxicity, demonstrating that CoFe2O4@MnFe2O4 is a good candidate for in vivo applications. Finally, in vivo MRI experiments showed that PEGylated CoFe2O4@MnFe2O4 NPs produce high T2 contrast and exhibit very good stealth properties, leading to the efficient evasion of the mononuclear phagocyte system. Thus, these bi-magnetic core-shell NPs show great potential as theranostic agents for in vivo applications, combining magnetic hyperthermia capabilities with high MRI contrast.

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Section: Transmission Electron Microscopysupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Bi-Magnetic Core-Shell CoFe2O4@MnFe2O4 Nanoparticles for In Vivo Theranostics

et al. 2020

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“…With regards to the improvement in SLP due to an interphase exchange mechanisms [27], an example shows synergistic effects (SLP ~500 W/g) in soft MnFe2O4 and hard CoFe2O4 bimagnetic clusters when compared with the homomagnetic 9 nm counterparts (~100 and ~200 W/g for Mn-and Co-ferrite, respectively) [28]. Such SLP values are similar to many others in the literature [29][30][31][32][33][34]. Overall, despite the superior magnetic hyperthermia response in many core-shell systems, recent experimental and theoretical studies failed to reproduce heating efficiencies above a few hundreds of watts per gram [35], in line with our observations (Table 2).…”

Section: Comparison With Other Core-shell Systemssupporting

confidence: 82%

Finding the Limits of Magnetic Hyperthermia on Core-Shell Nanoparticles Fabricated by Physical Vapor Methods

Martínez-Boubeta¹,

Simeonidis²,

Oró‐Solé

et al. 2021

Magnetochemistry

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Magnetic nanoparticles can generate heat when exposed to an alternating magnetic field. Their heating efficacy is governed by their magnetic properties that are in turn determined by their composition, size and morphology. Thus far, iron oxides (e.g., magnetite, Fe3O4) have been the most popular materials in use, though recently bimagnetic core-shell structures are gaining ground. Herein we present a study on the effect of particle morphology on heating efficiency. More specifically, we use zero waste impact methods for the synthesis of metal/metal oxide Fe/Fe3O4 nanoparticles in both spherical and cubic shapes, which present an interesting venue for understanding how spin coupling across interfaces and also finite size effects may influence the magnetic response. We show that these particles can generate sufficient heat (hundreds of watts per gram) to drive hyperthermia applications, whereas faceted nanoparticles demonstrate superior heating capabilities than spherical nanoparticles of similar size.

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“…Interesting advances have also been made in magnetic coatings to develop bimagnetic core–shell structures. The modulation of the core and shell dimensions regulates the interfacial exchange interaction between the two magnetic phases and allows precise control over the magnetic properties of these core–shell nanoparticles . Regarding the microbial synthesis, magnetic nanoparticles are obtained by a biomineralization route carried out by magnetotactic bacteria through a slow crystal growth process.…”

Section: Nanomaterials As Thermoseedsmentioning

confidence: 99%

Heating at the Nanoscale through Drug‐Delivery Devices: Fabrication and Synergic Effects in Cancer Treatment with Nanoparticles

et al. 2018

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that cancer cells are more sensitive to heat than normal ones [2,3] and the huge advances in the field of nanotechnology have given researchers new tools to design new, more sophisticated, and more specific heat treatments. Here, we focus on several electromagnetic responsive nanomaterials capable of acting as thermoseeds, which can induce changes in their environment through heating processes. We will pay special attention to the heat generation and its applications, as well as the biological response to the temperature rise at the nanoscale. Two sorts of nanomaterials that allow these new thermaltreatment approaches are especially attractive, depending on the radiation used to provoke the nanomaterial's response. Answering to the type of radiation used to carry out hyperthermia treatments, the nanomaterial characteristics required are completely different. The first application is typically called magnetic hyperthermia (MH), which uses alternating magnetic fields (AMFs); which are electromagnetic (EM) waves in the range of the EM spectrum that corresponds to radiofrequency (RF). The second, typically called optical hyperthermia, uses radiation in the part of the EM spectrum that corresponds to the near-infrared (NIR).The first approaches in hyperthermia treatments in both optical and magnetic stimuli mediated by nanoparticles were focused on the idea of using high doses of nanomaterials to produce enough heat to kill cancer cells by a global temperature increase. Researchers working in this field have to face several drawbacks, as the difficulty of localizing a high concentration of material in the target tissue, inadequate animal models, inaccurate temperature measurement, or limitations of the source conditions that can be used for in vivo experiments make the temperature rise often insufficient. [4] First, it is important to consider that the half-life and tissue penetration of the nanocarrier does not depend on the nanoparticle nature but on the coatings developed to enhance their stability in the physiological environment. Therefore, besides the heating efficiency, the predominant factor in the choice of hyperthermia generation is restricted by the location of the cancer tissue. Both RF and NIR irradiation can be considered useful external and noninvasive stimuli, but the main difference between the two is the tissue penetration. While magnetic fields Nanocarriers for cancer therapy have been extensively studied, but there is still some research that must be addressed in order to achieve their safe application. In this field, hyperthermia thermal treatments mediated by the use of responsive nanomaterials are not different, and researchers have carried out many attempts to overcome their drawbacks due to the valuable potential of these techniques. Here, an overview is presented of nanodevices based on magnetic-and photoresponsive nanocrystals that respond to magnetic fields and/or near-infrared stimuli for cancer therapies. Special attention is given to the synergic effect that can be achieved with nanoscal...

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Synthesis and Characterization of Bi-Magnetic Core/Shell Nanoparticles for Hyperthermia Applications

Cited by 12 publications

References 28 publications

Bi-Magnetic Core-Shell CoFe2O4@MnFe2O4 Nanoparticles for In Vivo Theranostics

Bi-Magnetic Core-Shell CoFe2O4@MnFe2O4 Nanoparticles for In Vivo Theranostics

Finding the Limits of Magnetic Hyperthermia on Core-Shell Nanoparticles Fabricated by Physical Vapor Methods

Heating at the Nanoscale through Drug‐Delivery Devices: Fabrication and Synergic Effects in Cancer Treatment with Nanoparticles

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