Synthesis and characterization of biocompatible-nanohydroxyapatite crystals obtained by a modified sol-gel processing

Abstract

A modified sol-gel process for synthesizing nanocrystalline hydroxyapatite powders (nHA) for biomedical applications, using tetrahydrated calcium nitrate [Ca(NO3)2∙4H2O] and phosphorous pentoxide [P2O5] as precursor, is presented and discussed. The powders were washed and heat-treated at different temperatures and then characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The total process time reached with this modified process was less than 16 h. The results showed that there was an increment in size of the HA nanocrystals (nHA) when treated at different temperatures, ranging from 30 nm for the sample treated at 600°C to 500 nm for the sample heat-treated at 1200°C.

Elucidation of differential mineralisation on native and regenerated silk matrices

“…The TEM images demonstrated that the fibroin could direct the assembly and nucleation of HA nanocrystals along the template (Figure 10). The typical needle-like morphology of HA crystals was well represented on 3D morphologies only, with aspect ratio measurements of nanocrystals close to that of synthesized HA [43]. The SAED images indicated a polycrystalline diffractogram for braided structures [34] (Figure 10) with preferential orientation extending along the c-axis, as also confirmed from the values of intensity ratio (Figure 6).…”

An exploratory study to evaluate the potential of nanohydroxyapatite as a powerful sorbent for efficient extraction of volatile organic metabolites, potential biomarkers of cancer

“…17 Nanomaterials usually show higher adsorption ability than their bulk counterparts. Nanohydroxyapatite (NHA), an important inorganic material in biology and chemistry, exhibits excellent biocompatibility and adsorption properties, 18 and has been widely used as a sorbent for the adsorption and separation of biomolecules (e.g. bovine serum albumin), 19 and for the removal of heavy metals (e.g.…”