Synthesis and characterization of biodegradable elastic hydrogels based on poly(ethylene glycol) and poly(ε-caprolactone) blocks

Im, Su Jin; Choi, You Mee; Subramanyam, Elango; Huh, Kang Moo; Park, Ki Nam

doi:10.1007/bf03218800

Cited by 27 publications

(22 citation statements)

References 19 publications

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“…Typical hydrogels are glassy and brittle in the dried state and it is diffi cult to change the shape and size of the dried state. Huh et al have developed biodegradable PEG/ PCL and PLGA -PEG -PLGA/PEG hydrogels showing fl exible and elastic properties even in the dried state that they remain intact after repeated bending or stretching to twice the original length [24] . Further, elastic hydrogels with self -healing capacity were synthesized by hydrophobic association through micellar copolymerization of AM and a small amount of octyl phenol polyethoxy ether acrylate.…”

Section: History Of Elastic Hydrogels As Biomaterialsmentioning

confidence: 99%

“…PEG is a hydrophilic polymer and its glass transition temperature is very low due to the fl exible chain structure. When PEG was used as a building block for preparing hydrogels with other biodegradable polyesters such as PGA, PLA, and PCL, the hydrogels can show fl exible and/or elastic properties [4, 24,27] . PEG has two hydroxyl groups at both ends of the polymer that can be modifi ed with a vinyl group to form a divinyl macromer.…”

Section: Crosslinking Of Water -Soluble Polymersmentioning

confidence: 99%

“…PEG acrylates are the major type of macromers for the preparation of PEG -based elastic hydrogels. For example, chemically crosslinked biodegradable elastic PEG/PCL or PLGA -PEG -PLGA/PEG hydrogels were prepared via radical crosslinking reaction of PEG -diacrylate with PCL -diacrylate or PLGA -PEG -PLGAdiacrylate in the presence of a radical initiator 2,2 -azobisisobutyronitrile in a drying oven at 65 ° C for 12 h [24] . Scheme 9.1 illustrates the synthetic method of PLGA -PEG -PLGA diacrylate using for crosslinking reaction with PEG -diacrylate under thermal catalyst.…”

Section: Crosslinking Of Water -Soluble Polymersmentioning

confidence: 99%

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Biodegradable Elastic Hydrogels for Tissue Expander Application

Trần

Garner

et al. 2011

Handbook of Biodegradable Polymers

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Section: History Of Elastic Hydrogels As Biomaterialsmentioning

confidence: 99%

Section: Crosslinking Of Water -Soluble Polymersmentioning

confidence: 99%

Section: Crosslinking Of Water -Soluble Polymersmentioning

confidence: 99%

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Biodegradable Elastic Hydrogels for Tissue Expander Application

Trần

Garner

et al. 2011

Handbook of Biodegradable Polymers

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“…[21][22][23] A great deal of different strategies for modification of these polymeric materials has been also intensively reported with the aim of fine-tuning of physicochemical properties on demand for practical applications by means of (i) chemically conjugation through copolymerization with poly(ethylene glycol) (PEG) [24][25][26][27] or biologically benign moieties, [28][29][30][31] and (ii) surface modification via surface coating, [32][33][34] blend, 35,36 and plasma treatment. 37 Those modifications make it possible to readily tailor the hydrophilicity, 32,35 specific interaction, 32,37 and other desired functions.…”

Section: Introductionmentioning

confidence: 99%

“…37 Those modifications make it possible to readily tailor the hydrophilicity, 32,35 specific interaction, 32,37 and other desired functions. 24,26,27 Specifically, block copolymer of polyester with featured components facilitates colloidal drug delivery carrier to be highly efficient in sustained release on specific target site. Colloidal carriers of polyester copolymer incorporated with PEG exhibit superior biodistribution by prolonged circulation in blood system because the mobile PEG brush serves as a protective shield around the particulate, significantly suppressing undesired adsorption of blood proteins onto therapeutic particulate.…”

Section: Introductionmentioning

confidence: 99%

Formation of poly(ethylene glycol)-poly(ε-caprolactone) Nanoparticles via Nanoprecipitation

et al. 2009

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Size control of therapeutic carriers in drug delivery systems has become important due to its relevance to biodistribution in the human body and therapeutic efficacy. To understand the dependence of particle size on the formation condition during nanoprecipitation method, we prepared nanoparticles from biodegradable, amphiphilic block copolymers and investigated the particle size and structure of the resultant nanoparticles according to various process parameters. We synthesized monomethoxy poly(ethylene glycol)-poly(ε-caprolactone) block copolymer, MPEG-PCL, with different MPEG/PCL ratios via ring opening polymerization initiated from the hydroxyl end group of MPEG. Using various formulations with systematic change of the block ratio of MPEG and PCL, solvent choice, and concentration of organic phase, MPEG-PCL nanoparticles were prepared through nanoprecipitation technique. The results indicated that (i) the nanoparticles have a dual structure with an MPEG shell and a PCL core, originating from self-assembly of MPEG-PCL copolymer in aqueous condition, and (ii) the size of nanoparticles is dependent upon two sequential processes: diffusion between the organic and aqueous phases and solidification of the polymer.

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Synthesis and characterization of biodegradable interpenetrating polymer networks based on gelatin and divinyl ester synthesized from poly(caprolactone diol)

Mohamed

Choudhary

Koul

2008

J of Applied Polymer Sci

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This article describes the synthesis and characterization of interpenetrating polymer networks (IPNs) from hydrophilic and hydrophobic polymers using emulsification technique. Tween 20 (0.001 wt % of gelatin) was employed as emulsifier for the preparation of semi and full IPNs. Gelatin (G), a hydrophilic component was crosslinked by glutaraldehyde (Glu) and divinyl ester (DVE), a hydrophobic component was polymerized/crosslinked using 3 mol % of AIBN as an initiator. Structural characterization was done using FTIR (doublet at 1620 and 1636 cm À1 ) and NMR (signals in the range of d ¼ 5-7 ppm), which confirmed the formation of DVE. Several samples were prepared by varying the ratio of gelatin : DVE (w/w) and the Glu concentration. The swelling characteristics (as a function of varying pH maintained using buffers) and degradation behavior (in phosphate buffer saline pH 7.4) of hydrogels was studied to investigate the effect of composition and crosslinker concentration. Percent water uptake decreased from 496 to 181 at pH 7.4 and pH 6.5 in IPNs as the concentration of DVE increased from 0.3 g to 0.7 g per g of gelatin. Semi-IPNs, where DVE was not polymerized, demonstrated higher swelling at pH 7.4 in contrast to pH 6.5 irrespective of Glu concentration. Gelatin hydrogels degraded within 180 h and IPNs degraded within 290 h whereas DVE did not degrade till the study period of 20 days. The formation of IPN was confirmed by thermal characterization (DSC, TGA) and scanning electron microscopy (SEM). Observation of cross-sectional microstructure of disrupted honeycomb of Gx into closely packed fiber-like structure upon interpenetration by SEM clearly suggests the formation of IPN.

show abstract

Synthesis and characterization of biodegradable elastic hydrogels based on poly(ethylene glycol) and poly(ε-caprolactone) blocks

Cited by 27 publications

References 19 publications

Biodegradable Elastic Hydrogels for Tissue Expander Application

Biodegradable Elastic Hydrogels for Tissue Expander Application

Formation of poly(ethylene glycol)-poly(ε-caprolactone) Nanoparticles via Nanoprecipitation

Synthesis and characterization of biodegradable interpenetrating polymer networks based on gelatin and divinyl ester synthesized from poly(caprolactone diol)

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