Synthesis and characterization of branched poly(l-glutamic acid) as a biodegradable drug carrier

Tansey, Wayne; Shi, Ke; Cao, Xianyi; Pasuelo, Marites J.; Wallace, Sidney; Li, Chun

doi:10.1016/j.jconrel.2003.09.005

Cited by 96 publications

(65 citation statements)

References 23 publications

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“…As previously shown, 16 this nano-bio interface is due to three dynamically interacting components: 1) the surface of NRs whose characteristics are determined …”

Section: Effects Of the Protein Corona On Nrsmentioning

confidence: 99%

Analyses of protein corona on bare and silica-coated gold nanorods against four mammalian cells

Das¹,

Yi²,

An³

2015

IJN

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The purpose of this study was to investigate the mechanisms responsible for the toxic effects of gold nanorods (AuNRs). Here, a comprehensive study was performed by examining the effects of bare (uncoated) AuNRs and AuNRs functionalized with silica (SiO 2 -AuNRs) against various mammalian cell lines, including cervical cancer cells, fibroblast cells, human umbilical vein endothelial cells, and neuroblastoma cells. The interactions between AuNRs and mammalian cells were investigated with cell viability and mortality assays. Dihydrorhodamine-123 assay was carried out for evaluating reactive oxygen species (ROS) generation, along with mass spectroscopy analysis for determining the composition of the protein corona. Our results suggest that even the lowest concentrations of AuNRs (0.7 μg/mL) induced ROS production leading to cell mortality. On the other hand, cellular viability and ROS production were maintained even at a higher concentration of SiO 2 -coated AuNRs (12 μg/mL). The increased production of ROS by AuNRs seemed to cause the toxicity observed in all four mammalian cell types. The protein corona on the bare AuNRs did not appear to reduce ROS generation; however, different compositions of the protein corona on bare and SiO 2 -coated AuNRs may affect cellular behavior differently. Therefore, it was determined that SiO 2 -coated AuNRs would be more advantageous than bare AuNRs for cellular applications.

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“…As previously shown, 16 this nano-bio interface is due to three dynamically interacting components: 1) the surface of NRs whose characteristics are determined …”

Section: Effects Of the Protein Corona On Nrsmentioning

confidence: 99%

Analyses of protein corona on bare and silica-coated gold nanorods against four mammalian cells

Das¹,

Yi²,

An³

2015

IJN

View full text Add to dashboard Cite

show abstract

“…Tansey et al described synthesis and characterization of branched poly( lglutamic acid) (PG) containing multiple PG chains centered on a PAMAM dendrimer or PEI cores [55] . The branched PG polymers were obtained by ring -opening polymerization of benzyl ester of l -glutamic acid N -carboxyanhydride using PAMAM or PEI as the initiator.…”

Section: Biological Implications Of Biodegradable Dendrimersmentioning

confidence: 99%

Biodegradable Dendrimers and Dendritic Polymers

Khandare

Kumar

2011

Handbook of Biodegradable Polymers

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“…Folate-targeted MTX dendrimer conjugate was significantly more active than the free drug. Other dendritic polymers such as polyarylethers and poly(L -glutamic acid) have also been studied for targeting using folic acid molecules [37,38].…”

Section: Bmentioning

confidence: 99%

“…Conjugation of lauroyl chains [13], polyglutamic acid [38], and PEG [62] to cationic dendrimers reduced their cytotoxicity significantly. Very recently, Schatzlein et al [63] used a novel propyleneimine dendrimer to achieve preferential delivery of DNA to the liver.…”

Section: Biodistribution and Safetymentioning

confidence: 99%

Dendrimers and Hyperbranched Polymers for Drug Delivery

Kannan

Perumal

Kannan

2007

Biomedical Applications of Nanotechnology

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Synthesis and characterization of branched poly(l-glutamic acid) as a biodegradable drug carrier

Cited by 96 publications

References 23 publications

Analyses of protein corona on bare and silica-coated gold nanorods against four mammalian cells

Analyses of protein corona on bare and silica-coated gold nanorods against four mammalian cells

Biodegradable Dendrimers and Dendritic Polymers

Dendrimers and Hyperbranched Polymers for Drug Delivery

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Synthesis and characterization of branched poly(l-glutamic acid) as a biodegradable drug carrier

Cited by 96 publications

References 23 publications

Analyses of protein corona on bare and silica-coated gold nanorods against four mammalian&nbsp;cells

Analyses of protein corona on bare and silica-coated gold nanorods against four mammalian&nbsp;cells

Biodegradable Dendrimers and Dendritic Polymers

Dendrimers and Hyperbranched Polymers for Drug Delivery

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Product

Resources

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Analyses of protein corona on bare and silica-coated gold nanorods against four mammalian cells

Analyses of protein corona on bare and silica-coated gold nanorods against four mammalian cells