Synthesis and characterization of calcium phosphate loaded with Ho-166 and Sm-153: a novel biomaterial for treatment of spine metastases

Donanzam, B. A.; Campos, Tânia Maria Mendonça; Dalmázio, Ilza; Valente, Eduardo Sarmento

doi:10.1007/s10856-013-5024-0

Cited by 17 publications

(14 citation statements)

References 41 publications

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“…The dosimetry of bone cements was demonstrated by studies in computational models. 10 , 11 In Figure 2 , the employed computational model of the spinal cord is depicted. The model was developed with the aid of the SISCODES program and the transport of particles was made in code Monte Carlo N-Particle version 5 (MCNP5).…”

Section: Introductionmentioning

confidence: 99%

RADIOACTIVE CEMENT OF PMMA AND HAP-Sm-153, Ho-166, OR RE-188 FOR BONE METASTASIS TREATMENT

Montaño

Campos

2019

Acta ortop. bras.

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Polymethylmetacrylte (PMMA) is used in the fields of dentistry and biomedicine as a constituent of bone cements. Hydroxyapatite (HAp) is a bioceramic produced naturally in the bones. PMMA and HAp are fundamental constituents in the preparation of bone cements. Bisphosphonates have also been used as radiopharmaceutical in dental implants and nuclear medicine, or as palliative systemic treatment for pain reduction in bone metastasis. Vertebroplasty and kyphoplasty are bone cement-based techniques used in orthopedics, being minimally invasive procedures with low risks of infections, applied in osteoporosis and high-impact fractures. Recently, Núcleo de Radiações Ionizantes da Universidade Federal de Minas Gerais proposed a synthetic composite of M-HAp with a metallic nuclide M. After irradiation, M-HAp was added to PMMA, compounding a radioactive bone cement that can recover bone body stabilization, pasting microfractures and recomposing the anatomy and functionality of the affected parts by the compression of bone metastases, with possible pain reduction through quick radiation-induced decompression. Computational dosimetric models, and the synthesis and characterization of bioceramics that incorporate Re-188, Ho-166, or Sm-153 have demonstrated the benefits of these biometrics as promising alternative therapies, mainly from their ability to maintain the ionization in the bone structure, thereby sparing the spinal cord. This article presents a review on this topic. Level of Evidence V, Expert Opinion.

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Section: Introductionmentioning

confidence: 99%

RADIOACTIVE CEMENT OF PMMA AND HAP-Sm-153, Ho-166, OR RE-188 FOR BONE METASTASIS TREATMENT

Montaño

Campos

2019

Acta ortop. bras.

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“…Donanzam et al managed to generate stable bioceramics using the sol-gel technique (see section 3.2) in which 166 Ho is incorporated in calcium phosphate. Despite the described potential of the developed biomaterial, clinical trials are necessary to further investigate the bioactivity and efficacy in bone malignancies (Donanzam et al 2013).…”

Section: Miscellaneous Applicationsmentioning

confidence: 99%

The various therapeutic applications of the medical isotope holmium-166: a narrative review

Klaassen¹,

Arntz²,

Arranja

et al. 2019

EJNMMI radiopharm. chem.

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Over the years, a broad spectrum of applications of the radionuclide holmium-166 as a medical isotope has been established. The isotope holmium-166 is attractive as it emits high-energy beta radiation which can be used for a therapeutic effect and gamma radiation which can be used for nuclear imaging purposes. Furthermore, holmium-165 can be visualized by MRI because of its paramagnetic properties and by CT because of its high density. Since holmium-165 has a natural abundance of 100%, the only by-product is metastable holmium-166 and no costly chemical purification steps are necessary for production of nuclear reactor derived holmium-166. Several compounds labelled with holmium-166 are now used in patients, such Ho 166 -labelled microspheres for liver malignancies, Ho 166 -labelled chitosan for hepatocellular carcinoma (HCC) and [ 166 Ho]Ho DOTMP for bone metastases. The outcomes in patients are very promising, making this isotope more and more interesting for applications in interventional oncology. Both drugs as well as medical devices labelled with radioactive holmium are used for internal radiotherapy. One of the treatment possibilities is direct intratumoural treatment, in which the radioactive compound is injected with a needle directly into the tumour. Numerous other applications have been developed, like patches for treatment of skin cancer and holmium labelled antibodies and peptides. The second major application that is currently clinically applied is selective internal radiation therapy (SIRT, also called radioembolization), a novel treatment option for liver malignancies. This review discusses medical drugs and medical devices based on the therapeutic radionuclide holmium-166.

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“…Compared with most radiotherapy it is an invasive approach. 49,69,70 Systematic use of radionuclides A noninvasive and cost-effective method and easy to apply; can alleviate pain effectively.…”

Section: Radiosurgerymentioning

confidence: 99%

“…This strategy enhances the antitumour activity of the cement implant, and due to the characteristics of the emitted b radiation, the radiation can be limited to within a small local region. 49,69,70 This will cause less radiotherapy-induced toxicity than the parenteral application of strontium-89. 71 The advantages and disadvantages of various treatments are summarized in Table 2.…”

Section: Temporary Myelosuppression 71mentioning

confidence: 99%

“…From the 1970s, physicians tried to treat spine metastases using a Halo cast, 24 a Halo vest and radiotherapy 25 and surgery. 4,5,[26][27][28][29] Currently, a multidisciplinary approach is the most common treatment strategy for spine metastases, which usually includes surgery, [29][30][31][32][33][34][35][36] radiotherapy, 15,[37][38][39][40][41][42][43][44][45][46][47][48] bone cement, 49,50 bisphosphonates 51 and chemotherapy. 51 Radiotherapy is an efficient therapeutic approach for symptomatic spine metastases patients that has a low morbidity rate.…”

Section: Treatment Evolution Of Spine Metastasesmentioning

confidence: 99%

See 1 more Smart Citation

Treatment of spine metastases in cancer: a review

Chen

Zhao

et al. 2019

J Int Med Res

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As a consequence of the improvements in diagnostic technology along with gains in life expectancy of cancer patients, the incidence of spine metastases has increased. Spine metastases can affect the patient’s quality of life and negatively impact on their prognosis. Multidisciplinary treatments involve surgery, chemotherapy, radiosurgery and radiotherapy. Spine metastases should be treated using a multidisciplinary and integrated approach that involves spinal surgeons, medical oncologists and radiologists. More research is required to elucidate the pathological mechanisms involved in the aetiology of spine metastasis. This review describes the current situation regarding the diagnosis of spine metastasis, what is understood about the pathological development of spine metastasis and the evolution of the multidisciplinary treatments that are available for patients with spine metastases.

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Synthesis and characterization of calcium phosphate loaded with Ho-166 and Sm-153: a novel biomaterial for treatment of spine metastases

Cited by 17 publications

References 41 publications

RADIOACTIVE CEMENT OF PMMA AND HAP-Sm-153, Ho-166, OR RE-188 FOR BONE METASTASIS TREATMENT

RADIOACTIVE CEMENT OF PMMA AND HAP-Sm-153, Ho-166, OR RE-188 FOR BONE METASTASIS TREATMENT

The various therapeutic applications of the medical isotope holmium-166: a narrative review

Treatment of spine metastases in cancer: a review

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