Synthesis and Characterization of Chemically Cross-Linked Acrylic Acid/Gelatin Hydrogels: Effect of pH and Composition on Swelling and Drug Release

Bukhari, Syed Majid Hanif; Khan, Samiullah; Rehanullah, Muhammad; Ranjha, Nazar Muhammad

doi:10.1155/2015/187961

Cited by 171 publications

(99 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, introducing low-molecular-weight cross-linker or polymers with low water absorption can assist in reducing the water absorption rate of the PEG–PCL-DA hydrogel. 42,45,46 …”

Section: Resultsmentioning

confidence: 99%

Highly Elastic Biodegradable Single-Network Hydrogel for Cell Printing

Lee

Dai

et al. 2018

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Cell printing is becoming a common technique to fabricate cellularized printed scaffold for biomedical application. There are still significant challenges in soft tissue bioprinting using hydrogels, which requires live cells inside the hydrogels. Moreover, the resilient mechanical properties from hydrogels are also required to mechanically mimic the native soft tissues. Herein, we developed a visible-light cross-linked, single-network, biodegradable hydrogel with high elasticity and flexibility for cell printing, which is different from previous highly elastic hydrogel with double-network and two components. The single-network hydrogel using only one stimulus (visible light) to trigger gelation can greatly simplify the cell printing process. The obtained hydrogels possessed high elasticity, and their mechanical properties can be tuned to match various native soft tissues. The hydrogels had good cell compatibility to support fibroblast growth in vitro. Various human cells were bioprinted with the hydrogels to form cell–gel constructs, in which the cells exhibited high viability after 7 days of culture. Complex patterns were printed by the hydrogels, suggesting the hydrogel feasibility for cell printing. We believe that this highly elastic, single-network hydrogel can be simply printed with different cell types, and it may provide a new material platform and a new way of thinking for hydrogel-based bioprinting research.

show abstract

“…In addition, introducing low-molecular-weight cross-linker or polymers with low water absorption can assist in reducing the water absorption rate of the PEG–PCL-DA hydrogel. 42,45,46 …”

Section: Resultsmentioning

confidence: 99%

Highly Elastic Biodegradable Single-Network Hydrogel for Cell Printing

Lee

Dai

et al. 2018

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

“…The underlying relation denoted by (1) was used to determine the swelling ratio of the synthesized disc. 18,19 (1)…”

Section: Dynamic Swelling Studiesmentioning

confidence: 99%

“…The following equation provided the means to determine Q eq : 19 (2) W h represents the mass of swollen gel at equilibrium, and W d stands for original mass of dried hydrogel.…”

Section: Equilibrium Swelling Studiesmentioning

confidence: 99%

The Structural, Crystallinity and Thermal Properties of pH responsive Interpenetrating Gelatin/Sodium Alginate Based Polymeric Composites for the Controlled Delivery of Cetirizine HCl

Afzal¹,

Khan²,

Ranjha³

et al. 2018

tjps

Self Cite

View full text Add to dashboard Cite

Bu çalışmada, her bir polimerin farklı oranları kullanılarak pH duyarlı çapraz bağlı jelatin/sodyum aljinat hidrojellerinin tasarlanması ve sentezlemesi ve her bir polimerin dinamik, kararlı şişme ve model etken madde olarak seçilen setirizin hidroklorürün in vitro salım profiline etkisinin araştırılması amaçlanmıştır. Gereç ve Yöntemler: Bu jelatin ve sodyum aljinat hidrojelleri, oda sıcaklığında, çapraz bağlayıcı olarak glutaraldehitin kullanımıyla serbest radikal polimerizasyonu ile hazırlandı. Bu polimerik kompozitler, çeşitli önemli karakterizasyonları öngörmek için model sistemler olarak kullanıldı. Etken maddelerin in vitro salım modeli üç farklı ortamda (pH 1.2, 5.5, 7.5 iyonik kuvveti sabit tutulan fosfat tampon çözeltisi) araştırıldı. Solunum analizi, gözeneklilik, sol-jel analizi, çapraz bağlar arasındaki ortalama molekül ağırlığı (Mc), çözücü etkileşim parametresi (χ), polimerin hacim fraksiyonu (V 2,s) ve difüzyon gibi salım davranışını etkileyen çeşitli yapı özellik ilişkileri belirlendi. FTIR, XRD ve DSC analizi kullanılarak yapı, kristalinite ve termal stabilite doğrulandı. Objectives: The present work aimed to design and synthesize pH-sensitive cross-linked Ge/SA hydrogels using different ratios of each polymer, and to investigate the effect of each polymer on dynamic, equilibrium swelling, and in vitro release pattern of cetirizine hydrochloride, which was selected as a model drug. Materials and Methods: These gelatin and sodium alginate hydrogels were prepared at room temperature through free radical polymerization using glutaraldehyde as a crosslinker. These polymeric composites were used as model systems to envisage various important characterizations. The in vitro release pattern of drug was investigated in three different mediums (phosphate buffer solution of pH 1.2, 5.5, 7.5 whose ionic strength was kept constant). Various structure property relationships that affect its release behavior were determined such as swelling analysis, porosity, solgel analysis, average molecular weight between crosslinks (Mc), solvent interaction parameter (χ), volume fraction of polymer (V 2,s) and diffusion coefficient. The structural, crystallinity, and thermal stability were confirmed using FTIR, XRD, and DSC analysis. Results: These hydrogels showed maximum swelling at pH 1.2. Zero-order, first-order, Higuchi, and Peppas models were applied to demonstrate the release pattern of drug. The release of drug occurred through non-Fickian diffusion or anomalous mechanism. Porosity was found increased with an increase in concentration of both polymers, and porosity decreased when the concentration of the crosslinker was increased. Gel fraction increased with an increase in concentration of SA, Ge, and glutaraldehyde. Conclusion: The prepared pH sensitive hydrogels can be used as a potential carrier for the sustained delivery of cetirizine hydrochloride.

show abstract

“…According to this theory, average molecular weight between crosslinks (M c ) is calculated via Eq . .

M_{c} = - \frac{d_{p} {normalV}_{s} (|, {V_{p}}^{\frac{true}{1}} - V_{p} / 2)}{(|, normalln (|, 1 - V_{p}) + V_{p} + χ {V_{p}}^{2})}

where

V_{s}

is the molar volume of solvent and

χ

is the Flory‐Huggins polymer solvent interaction parameter.…”

Section: Characterizationsmentioning

confidence: 98%

“…First, volume fraction of polymer in the swollen gel,

V_{p}

, is calculated by using Eq . .

V_{p} = {([]|, 1 + \frac{d_{p}}{d_{s}} (|, \frac{m}{m_{0}} - 1))}^{- 1}

where

m

is the weight of swollen gel sample,

m_{0}

is the weight of dry gel,

d_{s}

is density of solvent (water), and

d_{p}

is the density of dry gel.…”

Section: Characterizationsmentioning

confidence: 99%

Preparation of partially neutralized poly(acrylic acid) microspheres via inverse pickering suspension polymerization

Ceylan

Kaya

Sarac

2018

Polymer Engineering & Sci

View full text Add to dashboard Cite

Partially neutralized poly(acrylic acid) (PAA) microspheres have been prepared by Inverse Pickering Suspension Polymerization (IPSP) using 1,2‐dichlorobenzene (DCB) and hydrophobic fumed silica nanoparticles (HFSi‐NPs) as organic dispersing media and dispersing agent respectively. As crosslinker N,N'‐methylene bisacrylamide (MBAc), as initiator potassium persulfate (KPS) and sodium metabisulfite (SMBS) redox couple were used. Neutralization degrees were adjusted using 8N NaOH solution and polymerizations were initiated at 34°C. Water/oil phase ratio was set to 1/7 for all polymerizations. Morphology of prepared dry poly(acrylic acid) beads was examined by two microscopic methods, scanning electron microscopy (SEM) and optical microscopy. Prepared microsized polymer beads were observed as smooth and spherical in shape. Effect of neutralization degree (α) varied from 70% to 90% on absorptions in both distilled water and saline solutions, absorption under load (AUL) and crosslink density (CD) results were also investigated. POLYM. ENG. SCI., 59:162–169, 2019. © 2018 Society of Plastics Engineers

show abstract

Synthesis and Characterization of Chemically Cross-Linked Acrylic Acid/Gelatin Hydrogels: Effect of pH and Composition on Swelling and Drug Release

Cited by 171 publications

References 35 publications

Highly Elastic Biodegradable Single-Network Hydrogel for Cell Printing

Highly Elastic Biodegradable Single-Network Hydrogel for Cell Printing

The Structural, Crystallinity and Thermal Properties of pH responsive Interpenetrating Gelatin/Sodium Alginate Based Polymeric Composites for the Controlled Delivery of Cetirizine HCl

Preparation of partially neutralized poly(acrylic acid) microspheres via inverse pickering suspension polymerization

Contact Info

Product

Resources

About