Synthesis and characterization of chitosan:SiO2 nanocomposite by ultrasonic spray drying

Azhary, Sundoro Yoga; Purnama, Destiana; Florena, Fenfen Fenda; Vanitha, M.; Muchtaridi, Muchtaridi; Panatarani, Camellia; Joni, I Made

doi:10.1088/1757-899x/550/1/012037

Cited by 13 publications

(7 citation statements)

References 15 publications

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“…This Si-OH band was most prominent in aerogels without GPTMS, (CS1G0 and CS4G0) associating silanol groups with TEOS precursor rather than with the crosslinker. The absorption peak centered at about 3400 cm −1 is assigned to free or adsorbed water and is accompanied by the peak observed at 1640 cm −1 , a characteristic peak for the Si-OH bond, accounting for the hydrophilic behavior of the silica aerogels [52,53]. Then, its relative intensity decreases as GPTMS content increases, as shown in Figure 4.…”

Section: Fourier Transformed Infra-red (Ftir) Spectral Analysismentioning

confidence: 92%

“…FTIR spectra showed an intensive broad absorption band located at 1090 cm −1 showing intensity increase due to the absorption from the Si-O-C bonds, and a peak at 800 cm −1 , associated to strong Si-O-Si stretching vibrations. Another band is positioned at 950 cm −1 featuring the non-bridging oxygens (Si-OH bonds) in the silica network [40,52,53]. This Si-OH band was most prominent in aerogels without GPTMS, (CS1G0 and CS4G0) associating silanol groups with TEOS precursor rather than with the crosslinker.…”

Section: Fourier Transformed Infra-red (Ftir) Spectral Analysismentioning

confidence: 99%

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Chitosan-GPTMS-Silica Hybrid Mesoporous Aerogels for Bone Tissue Engineering

et al. 2020

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This study introduces a new synthesis route for obtaining homogeneous chitosan (CS)-silica hybrid aerogels with CS contents up to 10 wt%, using 3-glycidoxypropyl trimethoxysilane (GPTMS) as coupling agent, for tissue engineering applications. Aerogels were obtained using the sol-gel process followed by CO2 supercritical drying, resulting in samples with bulk densities ranging from 0.17 g/cm3 to 0.38 g/cm3. The textural analysis by N2-physisorption revealed an interconnected mesopore network with decreasing specific surface areas (1230–700 m2/g) and pore sizes (11.1–8.7 nm) by increasing GPTMS content (2–4 molar ratio GPTMS:CS monomer). In addition, samples exhibited extremely fast swelling by spontaneous capillary imbibition in PBS solution, presenting swelling capacities from 1.75 to 3.75. The formation of a covalent crosslinked hybrid structure was suggested by FTIR and confirmed by an increase of four hundred fold or more in the compressive strength up to 96 MPa. Instead, samples synthesized without GPTMS fractured at only 0.10–0.26 MPa, revealing a week structure consisted in interpenetrated polymer networks. The aerogels presented bioactivity in simulated body fluid (SBF), as confirmed by the in vitro formation of hydroxyapatite (HAp) layer with crystal size of approximately 2 µm size in diameter. In vitro studies revealed also non cytotoxic effect on HOB® osteoblasts and also a mechanosensitive response. Additionally, control cells grown on glass developed scarce or no stress fibers, while cells grown on hybrid samples showed a significant (p < 0.05) increase in well-developed stress fibers and mature focal adhesion complexes.

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Section: Fourier Transformed Infra-red (Ftir) Spectral Analysismentioning

confidence: 92%

Section: Fourier Transformed Infra-red (Ftir) Spectral Analysismentioning

confidence: 99%

Chitosan-GPTMS-Silica Hybrid Mesoporous Aerogels for Bone Tissue Engineering

et al. 2020

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“…Characteristic peaks/bands for gliclazide [25,56,57], sodium alginate [25,56,57], PDMS [25,58,59], TEOS [25,60,61] and chitosan [38,62,63] are presented in Figure 5 and Table 2. Silanol (-Si-OH) peaks of PDMS at 3281.53 cm −1 and 889.2 cm −1 disappeared in both control and G op microcapsules due to the crosslinking of the polymer with TEOS as previously reported [25].…”

Section: Bead Ftir Studymentioning

confidence: 99%

Polydimethylsiloxane Organic–Inorganic Composite Drug Reservoir with Gliclazide

Gedawy,

Al-Salami,

Dass

2024

IJMS

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A novel organic–inorganic gliclazide-loaded composite bead was developed by an ionic gelation process using acidified CaCl2, chitosan and tetraethylorthosilicate (TEOS) as a crosslinker. The beads were manufactured by crosslinking an inorganic silicone elastomer (-OH terminated polydimethylsiloxane, PDMS) with TEOS at different ratios before grafting onto an organic backbone (Na-alginate) using a 32 factorial experimental design. Gliclazide’s encapsulation efficiency (EE%) and drug release over 8 h (% DR 8 h) were set as dependent responses for the optimisation of a pharmaceutical formula (herein referred to as ‘G op’) by response surface methodology. EE % and %DR 8 h of G op were 93.48% ± 0.19 and 70.29% ± 0.18, respectively. G op exhibited a controlled release of gliclazide that follows the Korsmeyer–Peppas kinetic model (R2 = 0.95) with super case II transport and pH-dependent swelling behaviour. In vitro testing of G op showed 92.17% ± 1.18 cell viability upon testing on C2C12 myoblasts, indicating the compatibility of this novel biomaterial platform with skeletal muscle drug delivery.

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“…Cympopogon citratus extract FTIR spectrum reveled a peak at 1033.66 cm -1 which corresponds to the symmetric and asymmetric stretching vibration of C-O-C 80,81 . In the FTIR spectrum of CNPs, the peak at 1030.02 cm −1 is attributed to the C-O stretching vibration 81,82 .…”

Section: Fourier Transforms Infrared (Ftir) Measurementsmentioning

confidence: 99%

A sustainable green-approach for biofabrication of chitosan nanoparticles, optimization, characterization, its antifungal activity against phytopathogenic Fusarium culmorum and antitumor activity

El-Naggar,

Shiha,

Mahrous

et al. 2024

Sci Rep

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Chitosan is a natural non-toxic, biocompatible, biodegradable, and mucoadhesive polymer. It also has a broad spectrum of applications such as agriculture, medical fields, cosmetics and food industries. In this investigation, chitosan nanoparticles were produced by an aqueous extract of Cympopogon citratus leaves as a reducing agent. According to the SEM and TEM micrographs, CNPs had a spherical shape, and size ranging from 8.08 to 12.01 nm. CNPs have a positively charged surface with a Zeta potential of + 26 mV. The crystalline feature of CNPs is determined by X-ray diffraction. There are many functional groups, including C꞊C, CH2-OH, C–O, C-S, N–H, CN, CH and OH were detected by FTIR analysis. As shown by the thermogravimetric study, CNPs have a high thermal stability. For the optimization of the green synthesis of CNPs, a Face centered central composite design (FCCCD) with 30 trials was used. The maximum yield of CNPs (13.99 mg CNPs/mL) was produced with chitosan concentration 1.5%, pH 4.5 at 40 °C, and incubation period of 30 min. The antifungal activity of CNPs was evaluated against phytopathogenic fungus; Fusarium culmorum. A 100% rate of mycelial growth inhibition was gained by the application of 20 mg CNPs/mL. The antitumor activity of the green synthesized CNPs was examined using 6 different cell lines, the viability of the cells reduced when the concentration of green synthesized CNPs increased, the IC50 dose of the green synthesized CNPs on the examined cell lines HePG-2, MCF-7, HCT-116, PC-3, Hela and WI-38 was 36.25 ± 2.3, 31.21 ± 2.2, 67.45 ± 3.5, 56.30 ± 3.3, 44.62 ± 2.6 and 74.90 ± 3.8; respectively.

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Synthesis and characterization of chitosan:SiO2 nanocomposite by ultrasonic spray drying

Cited by 13 publications

References 15 publications

Chitosan-GPTMS-Silica Hybrid Mesoporous Aerogels for Bone Tissue Engineering

Chitosan-GPTMS-Silica Hybrid Mesoporous Aerogels for Bone Tissue Engineering

Polydimethylsiloxane Organic–Inorganic Composite Drug Reservoir with Gliclazide

A sustainable green-approach for biofabrication of chitosan nanoparticles, optimization, characterization, its antifungal activity against phytopathogenic Fusarium culmorum and antitumor activity

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