Synthesis and Characterization of Coated Iron Oxide Nanoparticles Produced for Drug Delivery in  Viscoelastic Solution

Antoniac, Iulian; Cernea, Alexandru; Petcu, Cristian; Lăptoiu, Dan; Tabaras, Diana; Tecu, Camelia; Antoniac, Aurora; Grădinaru, Sebastian

doi:10.37358/rc.20.4.8053

Cited by 3 publications

(4 citation statements)

References 4 publications

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“…This IR band is representative of the stretching vibration of Fe-O bonds in the crystalline lattices of iron oxide nanoparticles (magnetite and maghemite) [ 69 , 70 , 71 ], being also overlapped with the HA skeleton’s vibration bands. Other researchers obtained similar results [ 72 , 73 ]. The HA binding to the ferrophase nanoparticles resulted in a wavenumber shift for the C=O vibration from 1653 cm −1 to 1600 cm −1 and the band intensity decreased for the 3200 cm −1 peak (stretching vibrations of O-H and N-H groups) and the 1045 cm −1 peak (C-OH and C-C groups).…”

Section: Resultssupporting

confidence: 79%

“…The investigation with the ATR-FTIR technique evidenced HA’s interaction with the nanoparticle surface, since the main vibration bands were present in the recorded spectrum, being very similar to those reported in other studies [ 72 ]. Consequently, the applied procedure provides core–shell nanoparticles suitable for the further coupling of pharmaceutical products needed in oncologic chemotherapy.…”

Section: Discussionsupporting

confidence: 83%

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A Study of Hyaluronic Acid’s Theoretical Reactivity and of Magnetic Nanoparticles Capped with Hyaluronic Acid

Răcuciu,

Oancea,

Barbu-Tudoran

et al. 2024

Materials

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Hyaluronic acid (HA) has attracted much attention in tumor-targeted drug delivery due to its ability to specifically bind to the CD44 cellular receptor, which is widely expressed on cancer cells. We present HA-capped magnetic nanoparticles (HA-MNPs) obtained via the co-precipitation method, followed by the electrostatic adsorption of HA onto the nanoparticles’ surfaces. A theoretical study carried out with the PM3 method evidenced a dipole moment of 3.34 D and negatively charged atom groups able to participate in interactions with nanoparticle surface cations and surrounding water molecules. The ATR-FTIR spectrum evidenced the hyaluronic acid binding to the surface of the ferrophase, ensuring colloidal stability in the water dispersion. To verify the success of the synthesis and stabilization, HA-MNPs were also characterized using other investigation techniques: TEM, EDS, XRD, DSC, TG, NTA, and VSM. The results showed that the HA-MNPs had a mean physical size of 9.05 nm (TEM investigation), a crystallite dimension of about 8.35 nm (XRD investigation), and a magnetic core diameter of about 8.31 nm (VSM investigation). The HA-MNPs exhibited superparamagnetic behavior, with the magnetization curve showing saturation at a high magnetic field and a very small coercive field, corresponding to the net dominance of single-domain magnetic nanoparticles that were not aggregated with reversible magnetizability. These features satisfy the requirement for magnetic nanoparticles with a small size and good dispersibility for long-term stability. We performed some preliminary tests regarding the nanotoxicity in the environment, and some chromosomal aberrations were found to be induced in corn root meristems, especially in the anaphase and metaphase of mitotic cells. Due to their properties, HA-MNPs also seem to be suitable for use in the biomedical field.

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Section: Resultssupporting

confidence: 79%

Section: Discussionsupporting

confidence: 83%

A Study of Hyaluronic Acid’s Theoretical Reactivity and of Magnetic Nanoparticles Capped with Hyaluronic Acid

Răcuciu,

Oancea,

Barbu-Tudoran

et al. 2024

Materials

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“…Nanoparticles are widely used in biomedical applications, including orthopaedic (to reinforce composite materials for the replacement of damaged cartilage, meniscus, etc.) [ 23 , 24 , 25 ], drug delivery [ 26 , 27 , 28 ], viral sensing [ 29 ] or dental materials applications [ 30 ]. MPs are a category of nanoparticles of special interest that covers numerous such applications, including diagnosis, biosensing, tissue and immune therapy, regenerative medicine and dentistry [ 31 , 32 , 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

“…Regarding the first aim above, magnetic nanoparticles (MPs) manufactured in the laboratory are inserted in the adhesive, which is prepared with different procedures to optimize the adhesive distribution in the interface. Nanoparticles [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ], including MPs are largely used in medicine [ 31 , 32 , 33 , 34 , 35 ]. To our knowledge, we proposed using MPs for the first time in a series of preliminary studies [ 36 , 37 , 38 ] with the scope of obtaining a tighter connection between the composite material and the dental surface [ 39 , 40 ], compared with a conventional treatment.…”

Section: Introductionmentioning

confidence: 99%

Dental Adhesive Interfaces Reinforced with Magnetic Nanoparticles: Evaluation and Modeling with Micro-CT versus Optical Microscopy

et al. 2020

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Dental adhesives are used in a wide range of applications, including to place direct composite restorations in frontal or posterior teeth. One of the most frequent causes for the failure of composite resin restorations is microleakages. The first aim of this work is to introduce a new type of self-etched dental adhesive doped with magnetic nanoparticles (MPs) synthetized in the laboratory. The scope is to produce adhesives with a minimized width/thickness to decrease the risk of microleakages. The second aim is to assess the width/thickness of the adhesive layer in all the characteristic areas of the teeth using both the less precise but most common optical microscopy and the more accurate and volumetric micro-Computed Tomography (CT) investigations. Twenty extracted teeth have been divided into four groups: Group 1 includes ‘blank’ samples with adhesives that are not doped with MPs; Group 2 includes samples with adhesives doped with MPs; Groups 3 and 4 include samples with adhesives doped with MPs that are subjected to an active magnetic field for 5 and 10 min, respectively. Microscopy investigations followed by micro-CT and EDAX are performed on the adhesive. While a rather good agreement is obtained between the microscopy and micro-CT results, the capability of the latter to offer a full volumetric reconstruction of the layer is exploited to analyze the adhesion of the four considered dental materials. Thus, from micro-CT results the graphs of the surface areas as functions of the adhesive layer width are modeled mathematically, as well as the volume of sealants, for each of the four groups. To our knowledge, it is the first time that such a methodology is used. Characteristic parameters are extracted and the ascertainment of the optimal parameter that should be utilized for such assessments is discussed. The study demonstrates the adhesion improvement produced for Groups 3 and 4, where MPs are used. It also concludes that the magnetic field should be applied to the adhesive material for the longest possible exposure time (with a trade-off with the clinical duration of the treatment).

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Magnetic Hyperthermia in Glioblastoma Multiforme Treatment

Manescu (Paltanea),

Antoniac,

Paltanea

et al. 2024

IJMS

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Glioblastoma multiforme (GBM) represents one of the most critical oncological diseases in neurological practice, being considered highly aggressive with a dismal prognosis. At a worldwide level, new therapeutic methods are continuously being researched. Magnetic hyperthermia (MHT) has been investigated for more than 30 years as a solution used as a single therapy or combined with others for glioma tumor assessment in preclinical and clinical studies. It is based on magnetic nanoparticles (MNPs) that are injected into the tumor, and, under the effect of an external alternating magnetic field, they produce heat with temperatures higher than 42 °C, which determines cancer cell death. It is well known that iron oxide nanoparticles have received FDA approval for anemia treatment and to be used as contrast substances in the medical imagining domain. Today, energetic, efficient MNPs are developed that are especially dedicated to MHT treatments. In this review, the subject’s importance will be emphasized by specifying the number of patients with cancer worldwide, presenting the main features of GBM, and detailing the physical theory accompanying the MHT treatment. Then, synthesis routes for thermally efficient MNP manufacturing, strategies adopted in practice for increasing MHT heat performance, and significant in vitro and in vivo studies are presented. This review paper also includes combined cancer therapies, the main reasons for using these approaches with MHT, and important clinical studies on human subjects found in the literature. This review ends by describing the most critical challenges associated with MHT and future perspectives. It is concluded that MHT can be successfully and regularly applied as a treatment for GBM if specific improvements are made.

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Synthesis and Characterization of Coated Iron Oxide Nanoparticles Produced for Drug Delivery in Viscoelastic Solution

Cited by 3 publications

References 4 publications

A Study of Hyaluronic Acid’s Theoretical Reactivity and of Magnetic Nanoparticles Capped with Hyaluronic Acid

A Study of Hyaluronic Acid’s Theoretical Reactivity and of Magnetic Nanoparticles Capped with Hyaluronic Acid

Dental Adhesive Interfaces Reinforced with Magnetic Nanoparticles: Evaluation and Modeling with Micro-CT versus Optical Microscopy

Magnetic Hyperthermia in Glioblastoma Multiforme Treatment

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