Synthesis and characterization of different complexes derived from Schiff base and evaluation as a potential anticancer, antimicrobial, and insecticide agent

Aroua, Lotfi M.; Alhag, Sadeq K.; Al-Shuraym, Laila A.; Messaoudi, Sabri; Mahyoub, Jazem A.; Alfaifi, Mohammad Y.; Al-Otaibi, Wafa Mohammed

doi:10.1016/j.sjbs.2023.103598

Cited by 20 publications

(5 citation statements)

References 43 publications

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“…The ligand has many sites for coordination, which resulted in a variety of coordination modes. When compared to the free ligand, the IR spectra of all complexes exhibit a shift in the band of the azomethine N, v(C=N), from 1590 to 1643(1597 cm-1 in the free ligand) confirming its involvement in chelation [28]. The band due to the etheric O, v(C-O-C), found at 1049 cm-1 in the free ligand IR spectrum was found at 1039-1056 cm-1 in the metal complexes IR spectra.…”

Section: Ir Spectral Studymentioning

confidence: 84%

Computer modeling, docking, spectroscopic analysis, and antibacterial testing of metal chelates with dioxatetraaza ligand.

Zayed,

El-Sayed,

Abd El Salam

et al. 2023

Egypt. J. Chem.

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The goal of our current research is to create novel compounds of Co(II), Ni(II), Cu(II), Cr(III), Fe(III) and Zn(II) metal ions from heterocyclic dioxatetraaza ligand by the reaction of N1,N1'-(ethane-1,2-diyl)bis(ethane-1,2-diamine)with 2,2'-(ethane-1,2-diylbis(oxy))dibenzaldehyde to find out combating agent against microorganism diseases. Various physicochemical and spectroscopic techniques, including FT-IR, 1H and magnetic susceptibility, mass spectrometry, TGA, and others, were used to precisely characterize the synthesized compounds. These techniques suggested that the complexes' octahedral geometry was formed by epoxy oxygen atoms, azomethine nitrogen atomsof the dioxatetraaza ligand, and oxygen from the water molecules. The compounds' in vitro antibacterial activity against two bacterial and fungal pathogens was evaluated using the serial dilution method. Theoretical molecular docking was used to confirm these findings.

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Section: Ir Spectral Studymentioning

confidence: 84%

Computer modeling, docking, spectroscopic analysis, and antibacterial testing of metal chelates with dioxatetraaza ligand.

Zayed,

El-Sayed,

Abd El Salam

et al. 2023

Egypt. J. Chem.

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“…Since the synthesis of dithiocarbamic acids by Curtius more than a century ago, a significant number of S-alkyl/aryl-esters, their related complexes, and the Schiff bases of these compounds have been developed for potential use in antibacterial, anticancer, antifungal, antitumor, antiamoebic therapy, anti-inhibitory cell migration, analgesic and anti-inflammatory activities, or merely for their diverse coordination geometries [7][8][9][10].…”

Section: Historical Backgroundmentioning

confidence: 99%

“…Schiff bases have gained significant importance in medicinal chemistry, serving as versatile compounds with applications as drug intermediates and bioactive molecules [7,8,32,33]. The unique structural features of Schiff bases, combined with their diverse pharmacological activities, make them valuable candidates for drug development.…”

Section: Medicinal Chemistry: Schiff Bases As Drug Intermediates and ...mentioning

confidence: 99%

Schiff Bases: Contemporary Synthesis, Properties, and Applications

Hasibul Islam,

Abdul Hannan

2024

Novelties in Schiff Bases

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Schiff bases, a versatile class of organic compounds with a (>C〓N▬) functional group, have gained significant attention in contemporary chemistry due to their remarkable synthesis methods, diverse properties, and wide-ranging applications. This book chapter focused on Schiff bases, emphasizing their versatility in contemporary chemistry. It covers synthesis methods, structural aspects, and applications across multiple domains. The historical development of Schiff bases is traced, emphasizing their pivotal role in modern chemistry as key intermediates in various processes. The chapter delves into synthesis methods, including traditional, sustainable, and green chemistry approaches, and discusses structural aspects, spectroscopic characterization, thermodynamic properties, and kinetics. Schiff bases are categorized into various types, highlighting their diversity. Applications are explored in catalysis, asymmetric synthesis, coordination chemistry, medicinal chemistry, materials science, and environmental contexts. The chapter concludes with recent advances, emerging trends, and future directions, positioning it as a valuable resource for researchers, students, and practitioners interested in Schiff bases. The proposed chapter aims to explore the latest developments in Schiff bases, providing an in-depth review of their synthesis, properties, and applications across various scientific fields.

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“…Aroua et al (2023) [66] described the synthesis and characterization of diverse complexes derived from SBs and the evaluation of their antitumoral, antimicrobial, and insecticide activities. The antibacterial activity was studied against Gram-negative Escherichia coli and Gram-positive Bacillus subtilis (standard drug: tetracycline, IZD = 35 mm and 38 mm, respectively), whereas the antifungal activity was studied against Aspergillus niger (standard drug: nystatin, IZD = 32 mm).…”

Section: Sbs Complexes With Transition Metalsmentioning

confidence: 99%

Metal Complexes with Schiff Bases as Antimicrobials and Catalysts

Iacopetta,

Ceramella,

Catalano

et al. 2023

Inorganics

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Complexes of Schiff bases (SBs) with metals are promising compounds exhibiting a broad range of applications, such as catalysts, polymers, dyes, and several biological activities, including antimicrobial, anticancer, antioxidant, antimalarial, analgesic, antiviral, antipyretic, and antidiabetic actions. Considering the crisis that the whole world is now facing against antimicrobial-resistant bacteria, in the present review, we chose to focus on the activity of SBs as antimicrobials, particularly underlying the most recent studies in this field. Finally, some interesting catalytic applications recently described for metal complexes with SBs have also been discussed.

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Synthesis and characterization of different complexes derived from Schiff base and evaluation as a potential anticancer, antimicrobial, and insecticide agent

Cited by 20 publications

References 43 publications

Computer modeling, docking, spectroscopic analysis, and antibacterial testing of metal chelates with dioxatetraaza ligand.

Computer modeling, docking, spectroscopic analysis, and antibacterial testing of metal chelates with dioxatetraaza ligand.

Schiff Bases: Contemporary Synthesis, Properties, and Applications

Metal Complexes with Schiff Bases as Antimicrobials and Catalysts

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