Synthesis and characterization of dual light/temperature-responsive supramolecular injectable hydrogel based on host-guest interaction between azobenzene and starch-grafted β-cyclodextrin: Melanoma therapy with paclitaxel

Pourbadiei, Behzad; Adlsadabad, Samaneh Yousefi; Rahbariasr, Nikoo; Pourjavadi, Ali

doi:10.1016/j.carbpol.2023.120667

Cited by 21 publications

(9 citation statements)

References 45 publications

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“…2C). 69 At physiological temperature, the paclitaxel-loaded hydrogel exhibited a slow and sustainable release of paclitaxel within 96 hours. However, the CD/Azo host-guest interaction in the hydrogel gradually broke when exposed to 365 nm UV illumination, resulting in an increased release rate of paclitaxel and a significant inhibitory effect on tumor growth.…”

Section: Host-guest Interactionsmentioning

confidence: 98%

Engineered cyclodextrin-based supramolecular hydrogels for biomedical applications

Zhao,

Zheng,

et al. 2024

J. Mater. Chem. B

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Section: Host-guest Interactionsmentioning

confidence: 98%

Engineered cyclodextrin-based supramolecular hydrogels for biomedical applications

Zhao,

Zheng,

et al. 2024

J. Mater. Chem. B

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“…Pourjavadi's team designed and synthesized an injectable hydrogel with a dual response to temperature and UV light through the host-guest interaction mechanism (Fig. 4) (Pourbadiei et al 2023). The preparation process is complex.…”

Section: Drug Deliverymentioning

confidence: 99%

Thermosensitive injectable polysaccharide-based hydrogels: Gelation mechanisms, synthetic strategies, biomedical applications, and challenges

Sun,

Jiang

et al. 2024

BioRes

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In recent years, thermosensitive polysaccharide-based injectable hydrogels have gained increasing attention in biomedical applications, including wound healing, drug delivery, and cartilage repair. These hydrogels have favorable biocompatibility, biodegradability, and tunable physical and chemical properties. Thermosensitive polysaccharide-based injectable hydrogels are a class of intelligent soft matter material. They can undergo a reversible liquid-solid transition when exposed to temperature stimuli. Therefore, their precursor solutions can be accurately inserted into target sites with irregular geometries in a minimally invasive way and then transformed into gels in situ by the organism’s temperature stimulation to deliver biologically active molecules. This review summarizes the recent developments of thermosensitive injectable polysaccharide-based hydrogels. The focus is on the mechanism of sol-gel phase transition, as well as the design and preparation of thermosensitive polysaccharides and their applications in biomedical fields. In addition, the outlook of the challenges in biomedical applications is provided at the end of the paper.

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“…The porous structure offers an advantage for the use of obtained hydrogels as phototriggered vehicles for the delivery of drugs or biologically active compounds [42,58,59].…”

Section: Hydrogel Morphologymentioning

confidence: 99%

Cationic Azobenzenes as Light-Responsive Crosslinkers for Alginate-Based Supramolecular Hydrogels

Di Martino,

Sessa,

Panunzi

et al. 2024

Polymers

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Azobenzene photoswitches are fundamental components in contemporary approaches aimed at light-driven control of intelligent materials. Significant endeavors are directed towards enhancing the light-triggered reactivity of azobenzenes for such applications and obtaining water-soluble molecules able to act as crosslinkers in a hydrogel. Here, we report the rational design and the synthesis of azobenzene/alginate photoresponsive hydrogels endowed with fast reversible sol–gel transition. We started with the synthesis of three cationic azobenzenes (AZOs A, B, and C) and then incorporated them in sodium alginate (SA) to obtain photoresponsive supramolecular hydrogels (SMHGs). The photoresponsive properties of the azobenzenes were investigated by UV–Vis and 1H NMR spectroscopy. Upon irradiation with 365 nm UV light, the azobenzenes demonstrated efficient trans-to-cis isomerization, with complete isomerization occurring within seconds. The return to the trans form took several hours, with AZO C exhibiting the fastest return, possibly due to higher trans isomer stability. In the photoresponsive SMHGs, the minimum gelation concentration (MGC) of azobenzenes was determined for different compositions, indicating that small amounts of azobenzenes could induce gel formation, particularly in 5 wt% SA. Upon exposure to 365 nm UV light, the SMHGs exhibited reversible gel–sol transitions, underscoring their photoresponsive nature. This research offers valuable insights into the synthesis and photoresponsive properties of cationic, water-soluble azobenzenes, as well as their potential application in the development of photoresponsive hydrogels.

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Synthesis and characterization of dual light/temperature-responsive supramolecular injectable hydrogel based on host-guest interaction between azobenzene and starch-grafted β-cyclodextrin: Melanoma therapy with paclitaxel

Cited by 21 publications

References 45 publications

Engineered cyclodextrin-based supramolecular hydrogels for biomedical applications

Engineered cyclodextrin-based supramolecular hydrogels for biomedical applications

Thermosensitive injectable polysaccharide-based hydrogels: Gelation mechanisms, synthetic strategies, biomedical applications, and challenges

Cationic Azobenzenes as Light-Responsive Crosslinkers for Alginate-Based Supramolecular Hydrogels

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