Synthesis and characterization of elastic star shape-memory polymers as self-expandable drug-eluting stents

Liu, Xue; Dai, Shiyao; Li, Zhi

doi:10.1039/c2jm15918j

Cited by 48 publications

(34 citation statements)

References 52 publications

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“…To be used in such vascular applications, materials should exhibit mechanical strengths that accomplish intended functions and minimize adverse compliance mismatch-induced host responses [25-28], be biodegradable to prevent infectious complications [29-32], and demonstrate switch-like shape recovery near body temperature [32, 33] with favorable biocompatibility [34-36]. SMPs triggered by melting temperature (T m ) may be more appropriate for many biomedical applications because they tend to exhibit sharper phase transitions and higher, more switch-like shape recovery than SMPs that respond to glass transition temperature (T g ) [32, 37].…”

Section: Introductionmentioning

confidence: 99%

“…SMPs triggered by melting temperature (T m ) may be more appropriate for many biomedical applications because they tend to exhibit sharper phase transitions and higher, more switch-like shape recovery than SMPs that respond to glass transition temperature (T g ) [32, 37]. Moreover, covalently-crosslinked SMP networks are often preferable to physically-crosslinked ones because they tend to undergo less creep and irreversible deformation during programming steps [1, 38], exhibiting superior shape memory properties and thermal stability [39].…”

Section: Introductionmentioning

confidence: 99%

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Pendant allyl crosslinking as a tunable shape memory actuator for vascular applications

et al. 2015

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Thermo-responsive shape memory polymers (SMPs) can be fit into small-bore incisions and recover their functional shape upon deployment in the body. This property is of significant interest for developing the next generation of minimally-invasive medical devices. To be used in such applications, SMPs should exhibit adequate mechanical strengths that minimize adverse compliance mismatch-induced host responses (e.g. thrombosis, hyperplasia), be biodegradable, and demonstrate switch-like shape recovery near body temperature with favorable biocompatibility. Combinatorial approaches are essential in optimizing SMP material properties for a particular application. In this study, a new class of thermo-responsive SMPs with pendant, photocrosslinkable allyl groups, x%poly( -caprolactone)-co-y%( -allyl carboxylate -caprolactone) (x%PCL-y%ACPCL), are created in a robust, facile manner with readily tunable material properties. Thermomechanical and shape memory properties can be drastically altered through subtle changes in allyl composition. Molecular weight and gel content can also be altered in this combinatorial format to fine-tune material properties. Materials exhibit high elastic, switch-like shape recovery near 37 °C. Endothelial compatibility is comparable to tissue culture polystyrene (TCPS) and 100%PCL in vitro and vascular compatibility is demonstrated in vivo in a murine model of hindlimb ischemia, indicating promising suitability for vascular applications.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pendant allyl crosslinking as a tunable shape memory actuator for vascular applications

et al. 2015

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“…On the other hand, a few new shape memory phenomena have been discovered [31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47], which not only enhance the flexibility of the current shape memory technology, but also add in new dimensions for extended versatility and adoptability. Consequently, a number of novel concepts have been proposed for a range of engineering applications [45,[48][49][50][51][52][53][54], in particular in the field of biomedical engineering as of the last couple of years [24,43,[55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][70].…”

Section: Figurementioning

confidence: 99%

Mechanisms of the Shape Memory Effect in Polymeric Materials

et al. 2013

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Abstract:This review paper summarizes the recent research progress in the underlying mechanisms behind the shape memory effect (SME) and some newly discovered shape memory phenomena in polymeric materials. It is revealed that most polymeric materials, if not all, intrinsically have the thermo/chemo-responsive SME. It is demonstrated that a good understanding of the fundamentals behind various types of shape memory phenomena in polymeric materials is not only useful in design/synthesis of new polymeric shape memory materials (SMMs) with tailored performance, but also helpful in optimization of the existing ones, and thus remarkably widens the application field of polymeric SMMs.

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“…Thermally induced shape memory polymers have a wide range of applications in biomedical fields, [27] such as drug delivery, implanting, suture, and wound healing [28].…”

Section: Thermally Induced Shape Memory Polymersmentioning

confidence: 99%

Smart Delivery Systems with Shape Memory and Self-Folding Polymers

Erkeçoğlu¹,

Sezer²,

Bucak³

2016

Smart Drug Delivery System

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New generation delivery systems involve smart materials such as shape memory and self-folding polymers. Shape memory polymers revert back to their original shape above their glass transition temperatures where this temperature change can be induced conventionally, photolytically, with a lazer or magnetically depending on the composition of the material. This ability to assume original shape upon a trigger can be used in delivering drugs, DNA or cells. Self folding polymers are a new class of materials which may be composed of multilayers with different thermal expansion coefficients or with hinges that allow folding upon being triggered. These new materials allow various architectural designs of smart delivery vehicles predominantly for DNA and cells. The aim of this chapter is given shape and folding polymers and their usage for drug delivery systems.

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Synthesis and characterization of elastic star shape-memory polymers as self-expandable drug-eluting stents

Cited by 48 publications

References 52 publications

Pendant allyl crosslinking as a tunable shape memory actuator for vascular applications

Pendant allyl crosslinking as a tunable shape memory actuator for vascular applications

Mechanisms of the Shape Memory Effect in Polymeric Materials

Smart Delivery Systems with Shape Memory and Self-Folding Polymers

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