Synthesis and characterization of electrospun cerium-doped bioactive glass/chitosan/polyethylene oxide composite scaffolds for tissue engineering applications

Saatchi, Alieza; Arani, Ahmad Razaghian; Moghanian, Amirhossein; Mozafari, Masoud

doi:10.1016/j.ceramint.2020.08.130

Cited by 69 publications

(31 citation statements)

References 35 publications

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“…The negative Poisson’s ratio scaffold impressively provided a good environment for the growth and proliferation of bone marrow mesenchymal stem cell (mBMSC) and chondrogenic induction [ 102 ]. Electrospun nanofibers have been widely used in the past few years for various biomedical applications, including tissue engineering and regenerative medicine [ 135 , 136 ]. Chen et al [ 137 ] combined three-dimensional printing and freeze-drying to fabricate 3D scaffolds with large pores with precisely controlled shapes using pure gelatin fibers and poly (lactic-co-glycolic acid).…”

Section: Biopolymers-based Aerogels In Tissue Engineering For Therapeutic Applicationsmentioning

confidence: 99%

Insights into the Role of Biopolymer Aerogel Scaffolds in Tissue Engineering and Regenerative Medicine

et al. 2021

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The global transplantation market size was valued at USD 8.4 billion in 2020 and is expected to grow at a compound annual growth rate of 11.5% over the forecast period. The increasing demand for tissue transplantation has inspired researchers to find alternative approaches for making artificial tissues and organs function. The unique physicochemical and biological properties of biopolymers and the attractive structural characteristics of aerogels such as extremely high porosity, ultra low-density, and high surface area make combining these materials of great interest in tissue scaffolding and regenerative medicine applications. Numerous biopolymer aerogel scaffolds have been used to regenerate skin, cartilage, bone, and even heart valves and blood vessels by growing desired cells together with the growth factor in tissue engineering scaffolds. This review focuses on the principle of tissue engineering and regenerative medicine and the role of biopolymer aerogel scaffolds in this field, going through the properties and the desirable characteristics of biopolymers and biopolymer tissue scaffolds in tissue engineering applications. The recent advances of using biopolymer aerogel scaffolds in the regeneration of skin, cartilage, bone, and heart valves are also discussed in the present review. Finally, we highlight the main challenges of biopolymer-based scaffolds and the prospects of using these materials in regenerative medicine.

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Section: Biopolymers-based Aerogels In Tissue Engineering For Therapeutic Applicationsmentioning

confidence: 99%

Insights into the Role of Biopolymer Aerogel Scaffolds in Tissue Engineering and Regenerative Medicine

et al. 2021

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“…For example, the solvent of chitosan is generally toxic or an irritating liquid such as acetic acid, trifluoroacetic acid, HFIP, CF, etc. ; there are fiber beads in the process of electrospinning chitosan; the mechanical properties of the nanofibers are weak [ 114 , 115 , 116 ]. To avoid the use of toxic or irritating solvents such as HFIP, CF, TFA, and acetic acid, chitosan can be modified and made water-soluble.…”

Section: Antibacterial Materialsmentioning

confidence: 99%

Application of Electrospinning in Antibacterial Field

Chen

et al. 2021

Nanomaterials

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In recent years, electrospun nanofibers have attracted extensive attention due to their large specific surface area, high porosity, and controllable shape. Among the many applications of electrospinning, electrospun nanofibers used in fields such as tissue engineering, food packaging, and air purification often require some antibacterial properties. This paper expounds the development potential of electrospinning in the antibacterial field from four aspects: fiber morphology, antibacterial materials, antibacterial mechanism, and application fields. The effects of fiber morphology and antibacterial materials on the antibacterial activity and characteristics are first presented, then followed by a discussion of the antibacterial mechanisms and influencing factors of these materials. Typical application examples of antibacterial nanofibers are presented, which show the good prospects of electrospinning in the antibacterial field.

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“…The mechanical properties of CS nanofibers can be better enhanced with the blending of CS with polymers such as nylon-6, poly(vinyl alcohol), poly(caprolactone), polyethylene oxide (PEO), cellulose, and poly(lactic acid) [9]. To increase the spinnability of CS in this study, it was blended with PEO, which is a bio/mucoadhesive, semi-crystalline, and biocompatible synthetic polymer because of its ability to form hydrogen bonds [10,11].…”

Section: Introductionmentioning

confidence: 99%

Chitosan/PEO nanofibers electrospun on metallized track-etched membranes: fabrication and characterization

Pereao

Uche

Bublikov

et al. 2021

Materials Today Chemistry

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The development of next-generation adsorption, separation, and filtration materials is growing with an increased research focus on polymer composites. In this study, a novel blend of chitosan (CS) and polyethylene oxide (PEO) nanofiber mats was electrospun on titanium (Ti)-coated polyethylene terephthalate (PET) track-etched membranes (TMs) with after-treatment by glutaraldehyde in the vapor phase for enhancing the nanofiber stability by crosslinking. The prepared composite, titanium-coated track-etched nanofiber membrane (TTM-CPnf) was characterized by Fourier transform infra-red (FTIR), water contact angle, and scanning electron microscopy (SEM) analyses. Smooth and uniform CS nanofibers with an average fiber diameter of 156.55 nm were produced from a 70/30 CS/PEO blend solution prepared from 92 wt. % acetic acid and electrospun at 15 cm needle to collector distance with 0.5 mL/h flow rate and an applied voltage of 30 kV on the TTM-CPnf. Short (15 min) and long (72 h)-term solubility tests showed that after 3 h, crosslinked nanofibers were stable in acidic (pH ¼ 3), basic (pH ¼ 13), and neutral (pH ¼ 7) solutions. The crosslinked TTM-CPnf material was biocompatible based on the low mortality of freshwater crustaceans Daphnia magna. The composite membranes comprised of electrospun nanofiber and TMs proved to be biocompatible and may thus be suitable for diverse applications such as dual adsorptionefiltration systems in water treatment.

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Synthesis and characterization of electrospun cerium-doped bioactive glass/chitosan/polyethylene oxide composite scaffolds for tissue engineering applications

Cited by 69 publications

References 35 publications

Insights into the Role of Biopolymer Aerogel Scaffolds in Tissue Engineering and Regenerative Medicine

Insights into the Role of Biopolymer Aerogel Scaffolds in Tissue Engineering and Regenerative Medicine

Application of Electrospinning in Antibacterial Field

Chitosan/PEO nanofibers electrospun on metallized track-etched membranes: fabrication and characterization

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