Synthesis and characterization of gold nanotube/nanowire–polyurethane composite based on castor oil and polyethylene glycol

Ganji, Yasaman; Kasra, M.; Kordestani, Soheila S.; Hariri, Mohiedin Bagheri

doi:10.1016/j.msec.2014.05.030

Cited by 21 publications

(22 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Much progress has recently been made in order to fabricate porous polymer scaffolds, in particular by using salt leaching techniques [31][32][33]. The success of this method has been shown for a variety of soft and hard polymers [34][35][36][37], and we have recently established this procedure for PU [38].…”

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 99%

See 1 more Smart Citation

Cardiomyocyte behavior on biodegradable polyurethane/gold nanocomposite scaffolds under electrical stimulation

Ganji

Quabius

et al. 2016

Materials Science and Engineering: C

Self Cite

View full text Add to dashboard Cite

Following a myocardial infarction (MI), cardiomyocytes are replaced by scar tissue, which decreases ventricular contractile function. Tissue engineering is a promising approach to regenerate such damaged cardiomyocyte tissue. Engineered cardiac patches can be fabricated by seeding a high density of cardiac cells onto a synthetic or natural porous polymer. In this study, nanocomposite scaffolds made of gold nanotubes/nanowires incorporated into biodegradable castor oil-based polyurethane were employed to make micro-porous scaffolds. H9C2 cardiomyocyte cells were cultured on the scaffolds for one day, and electrical stimulation was applied to improve cell communication and interaction in neighboring pores. Cells on scaffolds were examined by fluorescence microscopy and scanning electron microscopy, revealing that the combination of scaffold design and electrical stimulation significantly increased cell confluency of H9C2 cells on the scaffolds. Furthermore, we showed that the gene expression levels of Nkx2.5, atrial natriuretic peptide (ANF) and natriuretic peptide precursor B (NPPB), which are functional genes of the myocardium, were up-regulated by the incorporation of gold nanotubes/nanowires into the polyurethane scaffolds, in particular after electrical stimulation.

show abstract

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 99%

“…Polyurethane-GNT/NW composites were synthesized according to our previous work [38]. In brief, gold nanotubes/nanowires (GNT/NW) were made by using template-assisted electrodeposition and mixed with castor oil/polyethylene glycol-based polyurethane (PU).…”

Section: Synthesis Of Polyurethane-gnt/nw Composite Scaffoldsmentioning

confidence: 99%

Cardiomyocyte behavior on biodegradable polyurethane/gold nanocomposite scaffolds under electrical stimulation

Ganji

Quabius

et al. 2016

Materials Science and Engineering: C

Self Cite

View full text Add to dashboard Cite

show abstract

“…Although there are host of raw materials used for making polyurethanes, continuous depletion of natural resources has made it imperative to identify alternate resources that are renewable or have plant origin [8]. Among the potential bio-based polyols, which are presently researched, one can find substances such as modified and unmodified castor oil [9][10][11], soybean oil [12][13][14][15], linseed oil [16,17] and so on.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of bio-castor oil polyurethane flexible foams and the influence of biotic component on their performance

et al. 2015

View full text Add to dashboard Cite

A series of bio-based polyurethane flexible foams were synthesized by substituting polyether polyol with castor oil and polyethylene glycol (PEG). The influence of the castor oil component in the prepolymers on the structure and properties of the castor oil-based polyurethane flexible foams were investigated and compared. FTIR (Fourier transform infrared spectroscopy) results confirmed that bio-based polyurethane was successfully synthesized by castor oil, PEG and MDI (diphenyl methane diisocyanate), and its urethane group content decreased as the castor oil content increased from 40 to 60 wt.%. TG (thermogravimetry) and DTG (derivative thermogravimetry) results showed that the thermal degradation of the bio-based polyurethane flexible foams occurred at about 150, 320 and 420°C. The Young's modulus improved from 0.196 to 1.235 KPa and the compression resilience improved from 97.76 to 99.65 % with increased content of castor oil. Moreover, these bio-based foams exhibited lower water absorption and higher contact angle with increased castor oil content.

show abstract

“…A concentration of 50 ppm of nanoparticles induced optimum cell distribution and spreading, as well as the largest up-regulated expression levels of genes relevant to cardiac differentiation and hypertrophy. In another work, Ganji et al [29] fabricated porous composite scaffolds for biomedical application based on gold nanotubes/nanowires and mixed with castor oilpolyethylene glycol-based polyurethanes. Addition of 50 or 100 ppm nanostructures had significant effects on thermal, mechanical, and cell attachment of fat-derived mesenchymal stem cells of polyurethanes.…”

Section: Medical Applicationsmentioning

confidence: 99%

“…Scaffolds show cell attachment of H9C2 cardiomyocyte cells [20] and fat-derived mesenchymal stem cells [29] …”

Section: Particle Leachingmentioning

confidence: 99%

Castor Oil Polyurethanes as Biomaterials

Valero¹

2017

Elastomers

View full text Add to dashboard Cite

Medical application of polyurethane (PU) elastomers has been contributed significantly to the quality and effectiveness of health care systems. Applications such as nasogastric catheter, sutures, wound dressing, drug delivery system, and insulation on the leads of electronics pacemakers are already in the market. Properties of polyurethanes such as thermal and chemical stability, mechanical performance, and low degradation rate make an outstanding material for that kind of application. More recently, castor oil as polyol source has been investigated due to the needs of friendly environmental sources. In this chapter, we want to approach the advances in polyurethane area from castor oil for application in medicines. A review of castor oil-based polyurethanes, chemical modification, processing techniques, and applications in tissue engineering and medical devices will be made with the objective to understand the current situation, limitations, challenges, and perspective of this type of material.

show abstract

Synthesis and characterization of gold nanotube/nanowire–polyurethane composite based on castor oil and polyethylene glycol

Cited by 21 publications

References 31 publications

Cardiomyocyte behavior on biodegradable polyurethane/gold nanocomposite scaffolds under electrical stimulation

Cardiomyocyte behavior on biodegradable polyurethane/gold nanocomposite scaffolds under electrical stimulation

Synthesis of bio-castor oil polyurethane flexible foams and the influence of biotic component on their performance

Castor Oil Polyurethanes as Biomaterials

Contact Info

Product

Resources

About