Synthesis and characterization of grafted thermosensitive hydrogels for heating activated controlled release

Insight into hydrogels

“…Using this approach, a temperature-dependent surface permeability and drug release kinetics can be achieved by grafting thermo-sensitive polymers on to the hydrogel surface such as PNIPAM polymers. [145] At low temperature, the drug is released rapidly but at higher temperature, it is remarkably slowed because at higher temperatures, there is phase transition and the thermos-responsive polymer collapses onto the surface of the hydrogel. Alternately, drug diffusion from the bulk hydrogel can be controlled by coating with a multilayer dense film of polyelectrolyte, [146] limiting drug diffusion out of the bulk hydrogel.…”

Magnetic and Multifunctional Magnetic Nanoparticles in Nanomedicine: Challenges and Trends in Synthesis and Surface Engineering for Diagnostic and Therapy Applications

“…The development of novel MNP carrier formulations continues apace. In general, advances are focusing on novel, multifunctional coatings, and the use of high-moment materials for the particle cores and the development of thermoresponsive hydrogels and particles (Ankareddi & Brazel, 2007). Although there have been numerous small animal studies reported since our last review, due to the technical barriers mentioned above, the goal of clinical applications remains largely unfulfilled.…”

Operating Room to Bench for Gastric Cancer

“…Thermosensitive hydrogels have gained increasing attention in the field of controlled drug release, to meet the need for prolonged and better control of drug administration, based on their intelligent and reversible behavior in response to temperature variation [25][26][27] . Reverse thermal gelation of biodegradable polymers has been reported [28][29][30][31][32] .…”