Synthesis and Characterization of Heteroleptic Copper and Zinc Complexes with Saccharinate and Aminoacids. Evaluation of SOD-like Activity of the Copper Complexes

Santi, E.; Viera, Inés; Mombrú, Álvaro W.; Castiglioni, Jorge; Baran, Enrique J.; Torre, Marı́a H.

doi:10.1007/s12011-011-8992-2

Cited by 16 publications

(10 citation statements)

References 35 publications

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“…Copper is the essential part of CER and Cu–Zn SOD ( Santi et al., 2011 , Vivoli et al., 1995 , Wu et al., 2014 ). In most vertebrates species (except birds), CER is the main form of copper in plasma and is believed to be the major protein that transports copper to extrahepatic tissues.…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary copper on elemental balance, plasma minerals and serum biochemical parameters of growing-furring male mink ( Mustela vison )

Gao

et al. 2015

Animal Nutrition

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The objectives of this study were to study the effects of different levels of dietary copper on copper and zinc balance, plasma minerals and serum biochemical parameters of mink in the growing-furring periods. One hundred and five standard dark male mink were randomly assigned to seven groups with the following dietary treatments: basal diet with no supplemental Cu (Control); basal diet supplemented with either 6, 12, 24, 48, 96, or 192 mg/kg Cu from copper sulfate, respectively. The average daily gain (ADG) linearly (P = 0.0026, P = 0.0006) responded to increasing levels of Cu; maximal growth was seen in the Cu24 group. Feed efficiency tended to improve with the increase of dietary copper level (linear P = 0.0010, quad, P = 0.0011). Fecal copper, urinary copper, retention copper responded in a linear (P < 0.05) fashion with increasing level of Cu. The effect of level of Cu was linear (P < 0.001) for plasma Cu concentration. The serum glutamic-oxalacetic transaminase (GOT) and glutamic-pyruvic transaminase (GPT) activities were increased linearly (P < 0.05) with dose of Cu, but serum total protein (TP) and albumin (ALB) concentrations decreased linearly (P < 0.05) as dietary copper levels increased. Effect of level of Cu was linear (P < 0.001) for serum ceruloplasmin (CER) concentration or Cu-Zn superoxide dismutase (Cu-Zn SOD) activity. Supplemental dose of Cu linearly decreased serum triglyceride (TG) (P = 0.011) and total cholesterol (TC) (P = 0.007). Our results indicated that the activity of Cu-dependent enzymes was enhanced by increasing dietary Cu concentration and that supplementation of Cu in the diet of mink could alter the plasma lipid profile and copper concentration.

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Section: Discussionmentioning

confidence: 99%

Effects of dietary copper on elemental balance, plasma minerals and serum biochemical parameters of growing-furring male mink ( Mustela vison )

Gao

et al. 2015

Animal Nutrition

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“…Values of plasma Cu or serum CER, although convenient markers of Cu nutritional status, are a relatively insensitive indice of tissue depletion. Copper is the essential part of CER and Cu-Zn SOD (Vivoli et al 1995;Santi et al 2011). In most vertebrate species (except birds), CER is the main form of Cu in plasma and is believed to be the major protein that transports Cu to extrahepatic tissues.…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary copper supplementation on nutrient digestibility, serum biochemical indices, and growth rate of young female mink (Neovison vison)

Wu¹,

Yang²,

Liu³

et al. 2014

CZECH J ANIM SCI

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ABSTRACT:The objective of this study was to determine whether nutrient digestibility and growth performance of mink were affected by different dietary copper levels. Ninety-six 60-day-old healthy female minks were randomly assigned to 8 treatment groups with 12 animals in each group and fed a diet supplemented with either 0, 4, 8, 16, 32, 64, 128 or 256 mg/kg copper as CuSO 4 × 5H 2 O, respectively. Our data showed that body weight and average daily gain increased (linear and quadratic, P < 0.05) as Cu increased in the diet, the highest body weight and average daily gain were seen in the Cu32 group. Feed : gain ratio responded in a linear (P = 0.0025) fashion with increasing level of Cu, the lowest feed : gain ratio was seen in the Cu64 group. Digestibility of ether extract responded in a linear (P = 0.0190) fashion with increasing level of Cu. There were no differences in apparent digestibility of dry matter, CP, and gross energy among groups (P > 0.05). N retention linearly (P = 0.0363) responded to increasing levels of Cu. Glutamic-oxalacetic transaminase and glutamic-pyruvic transaminase increased (linear and quadratic, P < 0.05) as Cu increased in the diet; the highest glutamicoxalacetic transaminase and glutamic-pyruvic transaminase were seen in the Cu256 group. Total protein of the minks was similar among the treatments, however, albumin in serum responded in a linear (P = 0.0370) and quadratic (P = 0.0049) fashion with increasing level of Cu. The activity of ceruloplasmin responded in a linear (P = 0.0001) and quadratic (P = 0.0203) fashion with increasing level of Cu. The activity of Cu-Zn superoxide dismutase responded in a linear (P = 0.0010) fashion with increasing level of Cu. Our results indicate that supplemental Cu plays an important role in the growth performance of mink, helping young female mink digest and efficiently utilize added dietary fat.

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“…Copper is an essential part of ceruloplasmin and Cu-Zn superoxide dismutase (Vivoli et al, 1995, Santi et al, 2011. In most species (except birds), ceruloplasmin is the main form of Cu in serum and is believed to be the major protein that transports Cu to extrahepatic tissues (Meyer et al, 2001;Das et al, 2007).…”

Section: Serum Traitsmentioning

confidence: 99%

Copper bioavailability, blood parameters, and nutrient balance in mink1

Zhang

Guo

et al. 2015

Journal of Animal Science

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A 3 × 3 + 1 factorial experiment was conducted based on a completely randomized design to evaluate the effects of different sources of copper on plasma metabolites, nutrient digestibility, relative copper bioavailability, and retention of some minerals in male mink. Animals in the control group were fed a basal diet, which mainly consisted of corn, fish meal, meat and bone meal, and soybean oil, with no copper supplementation. Mink in the other 9 treatments were fed the basal diet supplemented with Cu from reagent-grade copper sulfate (CuSO4), tribasic copper chloride (TBCC), or copper methionine (CuMet). Copper concentrations of the experimental diets were 50, 100, and 150 mg Cu/kg DM. Blood samples were collected via the toe clip at the end of study (d 42) to determine blood hematology and blood metabolites. A metabolism trial of 4 d was conducted during the last week of experimental feeding. There was a linear (P < 0.01) effect of dose of Cu on plasma Cu concentrations, ceruloplasmin concentration, and Cu-Zn superoxide dismutase activity. A linear response to Cu dose was noted for fat (P < 0.05) digestibility. Supplemental dose of Cu linearly increased (P < 0.05) liver Cu and decreased (P < 0.05) liver Zn level but did not alter liver Fe. The concentration of liver Cu of the mink fed with TBCC and CuMet diets was greater (P< 0.05) than that fed CuSO4. Compared with CuSO4 (100%), relative bioavailability values of TBCC were 104 and 104%, based on serum ceruloplasmin and liver copper, respectively, and relative bioavailability values of CuMet were 130 and 111%. CuMet and TBCC are more bioavailable than CuSO4. In conclusion, the relative bioavailability of CuMet obtained in this study was greater than that of CuSO4 and TBCC. Dose of Cu had an important effect on the regulating ceruloplasmin concentration, Cu-Zn superoxide dismutase activity, and the digestion of dietary fat in mink.

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Synthesis and Characterization of Heteroleptic Copper and Zinc Complexes with Saccharinate and Aminoacids. Evaluation of SOD-like Activity of the Copper Complexes

Cited by 16 publications

References 35 publications

Effects of dietary copper on elemental balance, plasma minerals and serum biochemical parameters of growing-furring male mink ( Mustela vison )

Effects of dietary copper on elemental balance, plasma minerals and serum biochemical parameters of growing-furring male mink ( Mustela vison )

Effects of dietary copper supplementation on nutrient digestibility, serum biochemical indices, and growth rate of young female mink (Neovison vison)

Copper bioavailability, blood parameters, and nutrient balance in mink1

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