Synthesis and characterization of highly efficacious Fe-doped ceria nanoparticles for cytotoxic and antifungal activity

Rahdar, Abbas; Aliahmad, Mousa; Samani, M. Ahmadpour; Majd, Mostafa Heidari; Susan, Md. Abu Bin Hasan

doi:10.1016/j.ceramint.2019.01.108

Cited by 57 publications

(31 citation statements)

References 21 publications

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“…In a recent study, different transition metal ions (Fe 2+ , Mn 2+ , and Co 2+ ) doped with nanosized hydroxyapatite (HA) were prepared for the increase of loadbearing capacity and strength; meanwhile, higher antibacterial activities were achieved against most tested bacteria compared with erythromycin (Panneerselvam et al, 2020). These transition metal elements (Fe, Mn, and Co) were also separately doped into CeO 2 NPs and proven to have enhanced antimicrobial activities (Khadar et al, 2019;Atif et al, 2019;Rahdar et al, 2019). The metal ions were placed into the atomic site of the Ce ions and substituted in the matrix of the host CeO 2 .…”

Section: Metal Element Doping Into Cerium Oxide Nps For Antibacterialmentioning

confidence: 99%

“…The metal ions were placed into the atomic site of the Ce ions and substituted in the matrix of the host CeO 2 . The bonding of metal ions with CeO 2 NPs was formed (Khadar et al, 2019;Atif et al, 2019;Rahdar et al, 2019). The antibacterial activity of various transition metal-doped metal oxide nanostructures comes from an electrostatic induction nature between NPs and the bacterial cell membrane (Khadar et al, 2019).…”

Section: Metal Element Doping Into Cerium Oxide Nps For Antibacterialmentioning

confidence: 99%

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Cerium and Its Oxidant-Based Nanomaterials for Antibacterial Applications: A State-of-the-Art Review

Zheng

et al. 2020

Front. Mater.

118

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Infectious diseases caused by bacteria remain a serious and global problem in human health. Herein, the discovery and application of antibiotics, which has attracted much attention in the past years, has helped to cure numerous infectious diseases and made huge contributions in the biomedical field. However, the widespread use of the broad-spectrum antibiotics has led to serious drug resistance for many human bacterial pathogens. In particular, bacterial drug resistance decreases therapeutic effects and leads to high mortality. Inspiringly, the introduction of nanomaterials in the biomedical field makes it possible to overcome the difficulty in bacterial drug resistance attributed to their unique antibacterial mechanism. Recently, a variety of metal-and metal oxide-based nanomaterials have been fully integrated in antibacterial applications and achieved excellent performances. Among them, cerium-and cerium oxide-based nanomaterials have received much attention worldwide. Remarkably, cerium oxide nanoparticles with lower toxicity act as effective antibacterial agents owing to their unique functional mechanism against pathogens through the reversible conversion of oxidation state between Ce(III) and Ce(IV). This article provides an overview of the state-of-the-art design and antibacterial applications of cerium-and cerium oxidebased materials. The first part discusses the underlying antibacterial mechanisms for cerium-and cerium oxide-based materials currently applied in biomedicine. The second part focuses on various antibacterial-related materials and their applications. In addition, the existing problems and future perspectives of the cerium-and cerium oxide-based materials make up the third part of this review. This paper could provide the possible mechanisms for antibacterial activities, various designs of cerium-and cerium oxide-based materials, and related antibacterial properties.

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Section: Metal Element Doping Into Cerium Oxide Nps For Antibacterialmentioning

confidence: 99%

Section: Metal Element Doping Into Cerium Oxide Nps For Antibacterialmentioning

confidence: 99%

Cerium and Its Oxidant-Based Nanomaterials for Antibacterial Applications: A State-of-the-Art Review

Zheng

et al. 2020

Front. Mater.

118

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“…Several reports have demonstrated the potential utilization of microemulsions as a delivery platform to improve the therapeutic action of targeted molecules, thus diminishing the toxicity of the drug to humans [ 13 , 15 , 17 , 23 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ]. Dhumal et al [ 47 ] developed a new self-micro-emulsifying drug delivery system (SMEDDS) by using oleic acid (semi-synthetic)-originated bicephalous heterolipid (E1E) for enhancing the bioavailability and solubility of curcumin.…”

Section: Introductionmentioning

confidence: 99%

“…Our research group recently developed Pluronic F127-based biodegradable and biocompatible microemulsions to increase the solubility and delivery of tocopherol. Besides the high encapsulation capacity, the as-formulated micro emulsion-based nanocarriers presented a sustained release profile of the cargo [ 39 ]. Nevertheless, no report has been conducted so far on preparing oil-in-water F127 microemulsions to augment the bioavailability of curcumin.…”

Section: Introductionmentioning

confidence: 99%

Biochemical, Ameliorative and Cytotoxic Effects of Newly Synthesized Curcumin Microemulsions: Evidence from In Vitro and In Vivo Studies

et al. 2021

Self Cite

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Curcumin is known to exhibit antioxidant and tissue-healing properties and has recently attracted the attention of the biomedical community for potential use in advanced therapies. This work reports the formulation and characterization of oil-in-water F127 microemulsions to enhance the bioavailability of curcumin Microemulsions showed a high encapsulation efficiency and prolonged release. To investigate the interactions of curcumin with one unit of the polymeric chain of surfactant F127, ethyl butyrate, and sodium octanoate, as well as the interaction between ethyl butyrate and one unit of the F127 polymer chain, the Density Functional Theory (DFT) calculations at the M06-2X level of theory, were performed in water solution. The MTT assay was used to assess the cytotoxicity of free and encapsulated curcumin on non-malignant and malignant cell lines. Combination effects were calculated according to Chou-Talalay’s principles. Results of in vitro studies indicated that MCF7 and HepG2 cells were more sensitive to curcumin microemulsions. Moreover, a synergistic relationship was observed between curcumin microemulsions and cisplatin in all affected fractions of MCF7 and HepG2 cells (CI < 0.9). For in vivo investigation, thioacetamide-intoxicated rats received thioacetamide (100 mg/kg Sc) followed by curcumin microemulsions (30 mg/kg Ip). Thioacetamide-intoxicated rats showed elevated serum liver enzymes, blood urea nitrogen (BUN), and creatinine levels, and a significant reduction in liver superoxide dismutase (SOD) and catalase (CAT) activities (p < 0.05). Curcumin microemulsions reduced liver enzymes and serum creatinine and increased the activity of antioxidant enzymes in thioacetamide-treated rats in comparison to the untreated thioacetamide-intoxicated group. Histopathological investigations confirmed the biochemical findings. Overall, the current results showed the desirable hepatoprotective, nephroprotective, and anti-cancer effects of curcumin microemulsions.

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“…Presently, the use of nanomaterials is very widespread and is used in many industries such as wastewater treatments, catalysts, sensors, and drug deliveries [1–5]. For many years, noble metal nanoparticles (NPs), especially silver (Ag), have been significantly applied in the biomedical field due to their physiochemical things [6–8].…”

Section: Introductionmentioning

confidence: 99%

Anticancer, antimicrobial, and dye degradation activity of biosynthesised silver nanoparticle using Artemisia kopetdaghensis

Yazdi

Darroudi

Amiri

et al. 2020

Micro & Nano Letters

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Synthesis and characterization of highly efficacious Fe-doped ceria nanoparticles for cytotoxic and antifungal activity

Cited by 57 publications

References 21 publications

Cerium and Its Oxidant-Based Nanomaterials for Antibacterial Applications: A State-of-the-Art Review

Cerium and Its Oxidant-Based Nanomaterials for Antibacterial Applications: A State-of-the-Art Review

Biochemical, Ameliorative and Cytotoxic Effects of Newly Synthesized Curcumin Microemulsions: Evidence from In Vitro and In Vivo Studies

Anticancer, antimicrobial, and dye degradation activity of biosynthesised silver nanoparticle using Artemisia kopetdaghensis

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