Synthesis and characterization of human bone-like hydroxyapatite using Schiff's base

Anandan, Dhivyaa; Jaiswal, Akhilesh

doi:10.1016/j.ceramint.2018.02.156

Cited by 16 publications

(8 citation statements)

References 25 publications

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“…Rsm designates the mean width of the profile elements for roughness, indicating the average length of the profile element along the sampling length. A typical nano-HAp crystallite has a needle-like morphology [ 57 ]. Therefore, our hypothesis for achieving a high SMHR% in a short treatment time is by filling the cavity of the etched enamel surface with nano-HAp crystallites in a horizontal settling/sitting way.…”

Section: Resultsmentioning

confidence: 99%

Rehardening and the Protective Effect of Gamma-Polyglutamic Acid/Nano-Hydroxyapatite Paste on Surface-Etched Enamel

et al. 2021

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Many revolutionary approaches are on the way pertaining to the high occurrence of tooth decay, which is an enduring challenge in the field of preventive dentistry. However, an ideal dental care material has yet to be fully developed. With this aim, this research reports a dramatic enhancement in the rehardening potential of surface-etched enamels through a plausible synergistic effect of the novel combination of γ-polyglutamic acid (γ-PGA) and nano-hydroxyapatite (nano-HAp) paste, within the limitations of the study. The percentage of recovery of the surface microhardness (SMHR%) and the surface parameters for 9 wt% γ-PGA/nano-HAp paste on acid-etched enamel were investigated with a Vickers microhardness tester and an atomic force microscope, respectively. This in vitro study demonstrates that γ-PGA/nano-HAp treatment could increase the SMHR% of etched enamel to 39.59 ± 6.69% in 30 min. To test the hypothesis of the rehardening mechanism and the preventive effect of the γ-PGA/nano-HAp paste, the surface parameters of mean peak spacing (Rsm) and mean arithmetic surface roughness (Ra) were both measured and compared to the specimens subjected to demineralization and/or remineralization. After the treatment of γ-PGA/nano-HAp on the etched surface, the reduction in Rsm from 999 ± 120 nm to 700 ± 80 nm suggests the possible mechanism of void-filling within a short treatment time of 10 min. Furthermore, ΔRa-I, the roughness change due to etching before remineralization, was 23.15 ± 3.23 nm, while ΔRa-II, the roughness change after remineralization, was 11.99 ± 3.90 nm. This statistically significant reduction in roughness change (p < 0.05) implies a protective effect against the demineralization process. The as-developed novel γ-PGA/nano-HAp paste possesses a high efficacy towards tooth microhardness rehardening, and a protective effect against acid etching.

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Section: Resultsmentioning

confidence: 99%

Rehardening and the Protective Effect of Gamma-Polyglutamic Acid/Nano-Hydroxyapatite Paste on Surface-Etched Enamel

et al. 2021

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“…In living systems, calcium phosphates exist in the form of crystalline HA. Hydroxyapatite, [Ca 10 (PO 4 ) 6 (OH) 2 , HA] and its derivatives are the most significant mineral phases of the natural bone tissues 3 . They can be synthesized by several chemical methods such as precipitation, microwave irradiation, sol‐gel, hydrothermal process, and thermal sintering 4‐6 which are widely used in biomedical applications 7 .…”

Section: Introductionmentioning

confidence: 99%

“…Hydroxyapatite, [Ca 10 (PO 4 ) 6 (OH) 2 , HA] and its derivatives are the most significant mineral phases of the natural bone tissues. 3 They can be synthesized by several chemical methods such as precipitation, microwave irradiation, sol-gel, hydrothermal process, and thermal sintering [4][5][6] which are widely used in biomedical applications. 7 Among these processes, sintering is a very straightforward and cost-effective method considering no expensive chemicals and specialized skills or knowledge are required.…”

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confidence: 99%

Comparative analysis and antibacterial properties of thermally sintered apatites with varied processing conditions

et al. 2020

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Biological waste holds a major portion of the municipal waste stream, particularly in rural areas of developing countries. According to the Food and Agriculture Organization of the United Nations (FAO), every year there are 1.3 billion tons of food waste produced and around one-third of all food produced for human consumption are being wasted. 1 Amongst the other sources, the livestock industry (fish and poultry industry) has a vital contribution. Some biological

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“…This biomaterial is an excellent ceramic scaffold to promote and strengthen the process of bone regeneration. BV contains a large amount of HA, which is one of the main components of the bone mineral matrix (50).…”

Section: Discussionmentioning

confidence: 99%

Application of Shark Teeth–Derived Bioapatites as a Bone Substitute in Veterinary Orthopedics. Preliminary Clinical Trial in Dogs and Cats

García-González

Muñoz

González‐Cantalapiedra

et al. 2020

Front. Vet. Sci.

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Background: The autograft is still considered the gold standard for the treatment of bone defects. However, given the significant morbidity of the donor site with which it has been associated, alternative substitutes for bone grafts have been developed. In the present study, a bone substitute composed of CaP biphasic bioceramics obtained from shark teeth was used (BIOFAST-VET).Objective: The objective of this study is to evaluate the efficacy of a marine bioapatite in the veterinary clinical field using it as a bone-grafting scaffold in dogs and cats. Methods:The biomaterial was randomly distributed in 6 veterinary clinical centers in Spain and was used in 24 cases (20 dogs and 4 cats) including 14 fractures, 9 arthrodesis, and 1 bone cyst. Grains between 500 and 2,000 µm were used. Inclusion and exclusion criteria were established. The time of consolidation and functional recovery were quantitatively and qualitatively assessed. For this, a follow-up was carried out at 2, 4, 8, and 12 weeks, included radiographic images, physical examination and sharing the feedback with the owners.Results: Nineteen cases completed the study (18 dogs and 1 cat; 11 fractures, 7 arthrodesis, and 1 bone cyst). The remaining five were excluded because they did not complete the radiographic follow-up (three cats and two dogs), being three arthrodesis and two fractures. In 18 of 19 cases, the use of the biomaterial was successful; the remaining one failed due to causes not related to the biomaterial. There were no systemic or local adverse reactions. Eighteen patients had a good functional recovery. The average consolidation time was 5.94 weeks in dogs with fractures and arthrodesis, not finding statistically significant differences between sex, weight, and procedure.Conclusions: This biomaterial is presented as a very suitable candidate for orthopedic surgery in the veterinary field. Preliminary results showed that its use reduces consolidation time in dogs with fractures and arthrodesis. In addition, no adverse systemic or local reactions have been observed derived from its use.

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Synthesis and characterization of human bone-like hydroxyapatite using Schiff's base

Cited by 16 publications

References 25 publications

Rehardening and the Protective Effect of Gamma-Polyglutamic Acid/Nano-Hydroxyapatite Paste on Surface-Etched Enamel

Rehardening and the Protective Effect of Gamma-Polyglutamic Acid/Nano-Hydroxyapatite Paste on Surface-Etched Enamel

Comparative analysis and antibacterial properties of thermally sintered apatites with varied processing conditions

Application of Shark Teeth–Derived Bioapatites as a Bone Substitute in Veterinary Orthopedics. Preliminary Clinical Trial in Dogs and Cats

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