Synthesis and characterization of hyaluronic acid hydrogels crosslinked using a solvent-free process for potential biomedical applications

Larrañeta, Eneko; Henry, Michelle; Irwin, Nicola; Trotter, Johann L.; Perminova, A. A.; Donnelly, Ryan F.

doi:10.1016/j.carbpol.2017.12.015

Cited by 228 publications

(167 citation statements)

References 59 publications

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“…IR820 was utilized to bond with Ara for the formation of prodrug (Ara‐IR820) because its sulfonic group could coordinate with the metal ions in ZIF‐8, strengthening the interactions and accomplishing a high drug loading. The hyaluronic acid (HA) was further functionalized on the Ara‐IR820@ZIF‐8 hybrids via the coordination effect between its carboxyls and metal ions in ZIF‐8 to realize the tumor‐targeted delivery system (HA/Ara‐IR820@ZIF‐8) . The fabrication of our drug delivery system was through in situ encapsulation, as illustrated in Scheme .…”

Section: Introductionmentioning

confidence: 99%

A Versatile Prodrug Strategy to In Situ Encapsulate Drugs in MOF Nanocarriers: A Case of Cytarabine‐IR820 Prodrug Encapsulated ZIF‐8 toward Chemo‐Photothermal Therapy

Zhang

Liu

et al. 2018

Adv Funct Materials

203

147

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Zeolitic imidazolate framework-8 (ZIF-8) is an attractive metal organic framework (MOF) in drug delivery. Strong interaction between drugs and ZIF-8 is essential for high drug loadings through in situ construction of MOFs. However, only limited drugs with unique functional groups (COOH, SO 3 H, et al.) can interact with ZIF-8 and be encapsulated satisfactorily so far. Drugs without these functional groups are difficult to be loaded due to the lack of strong interaction. Herein a versatile prodrug strategy is proposed to solve the problems encountered by MOFs. Cytarabine (Ara) is chosen as a model drug since it cannot be loaded in ZIF-8 satisfactorily by itself. New indocyanine green (IR820) is utilized to bond with Ara for the formation of prodrug (Ara-IR820) and endows the prodrug with fluorescence imagingguided chemo-photothermal therapy, in which sulfonic groups strengthen the interaction between prodrug and ZIF-8. This prodrug loaded ZIF-8 is further functionalized with hyaluronic acid (HA) to result in active-targeting HA/ Ara-IR820@ZIF-8 nanoparticles. The in vitro and in vivo results demonstrate its excellent visual cancer therapy with tumor-targeted and pH-responsive release behavior. This design offers a new concept to solve the drug loading problem of MOFs, exhibiting a flexible strategy to expand the biomedical applications of MOFs.

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Section: Introductionmentioning

confidence: 99%

A Versatile Prodrug Strategy to In Situ Encapsulate Drugs in MOF Nanocarriers: A Case of Cytarabine‐IR820 Prodrug Encapsulated ZIF‐8 toward Chemo‐Photothermal Therapy

Zhang

Liu

et al. 2018

Adv Funct Materials

203

147

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“…Because of the high biocompatibility and biodegradability, hydrogels have been adopted in fabricating MNs. The hydrogels can be roughly divided into two types: (1) natural hydrogels, such as cellulose,[2b,12] hyaluronic acid, chitosan, gelatin, and alginate; and (2) synthetic hydrogels, such as acrylate polymers, poly(β‐ester), polylactide, polyvinyl alcohol, and polyvinylpyrrolidone . Natural hydrogel‐based MNs usually possess innate biocompatibility and biodegradability and they have been applied to deliver a variety of drugs, ranging from small molecules to biomacromolecules.…”

mentioning

confidence: 99%

Biodegradable Gelatin Methacryloyl Microneedles for Transdermal Drug Delivery

Luo

Sun

Fang

et al. 2018

Adv Healthcare Materials

220

128

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Biocompatible and bioresponsive microneedles (MNs) are emerging technology platforms for sustained drug release with a potential to be a key player in transdermal delivery of therapeutics. In this paper, an innovative biodegradable MNs patch for the sustained delivery of drugs using a polymer patch, which can adjust delivery rates based on its crosslinking degree, is reported. Gelatin methacryloyl (GelMA) is used as the base for engineering biodegradable MNs. The anticancer drug doxorubicin (DOX) is loaded into GelMA MNs using the one molding step. The GelMA MNs can efficiently penetrate the stratum corneum layer of a mouse cadaver skin. Mechanical properties and drug release behavior of the GelMA MNs can be adjusted by tuning the degree of crosslinking. The efficacy of the DOX released from the GelMA MNs is tested and the anticancer efficacy of the released drugs against melanoma cell line A375 is demonstrated. Since GelMA is a versatile material in engineering tissue scaffolds, it is expected that the GelMA MNs can be used as a platform for the delivery of various therapeutics.

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“…It was noticeable that the spectra of the polymer‐sugar complexes presented differences with that of the physical mixtures at the same feeding ratios, indicating the old hydrogen bonds breaking and new bond forming. In particular, the CO stretching vibration of the amides (1652 cm −1 ) and the carboxyl (COO) groups (1616 cm −1 ) of HA shifted to higher frequency when combined with sucrose in all the complexes . The stretching vibration of the OH groups showed two characteristic bands at 3561 and 3390 cm −1 for physical mixtures, which attributed to the free hydroxyl groups and intramolecular hydrogen bonds, respectively.…”

Section: Resultsmentioning

confidence: 95%

Rational Design of Rapidly Separating Dissolving Microneedles for Precise Drug Delivery by Balancing the Mechanical Performance and Disintegration Rate

Hou

Quan

Yang

et al. 2019

Adv Healthcare Materials

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The precise delivery of traditional dissolving microneedles (TDMNs) is often limited by the incomplete insertion due to the skin deformation, and the topical irritation is inevitable after long application, which ultimately results in compromised therapeutic efficacy. The aim of this study is to develop a rapidly separating dissolving microneedles (RSDMNs) system to achieve precise drug delivery. Therapeutic molecules are concentrated in the needle tip, while the blank separating part allows it to counteract skin indentation and rapidly separate from the base part. For rational design of an ideal separating part, and the molecular interactions between polymer and sugar are explored to make a good balance between mechanical performance and disintegration rate. The optimal RSDMNs can rapidly disintegrate in the mimic skin within 30 s, and the generated micropores in the skin reseal quickly. The ex vivo drug permeation of RSDMNs is significantly higher than that of TDMNs due to the complete needle imbed aided by the separating part. Furthermore, RSDMNs exhibit excellent in vivo anti‐inflammation effect by remarkably down regulating the expression of TNF‐α, IL‐1β, and IL‐6. In conclusion, the RSDMNs can reach precise drug delivery in a short time, which are more reliable for the self‐administration strategy in the future.

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Synthesis and characterization of hyaluronic acid hydrogels crosslinked using a solvent-free process for potential biomedical applications

Abstract: Graphical abstract

Cited by 228 publications

References 59 publications

A Versatile Prodrug Strategy to In Situ Encapsulate Drugs in MOF Nanocarriers: A Case of Cytarabine‐IR820 Prodrug Encapsulated ZIF‐8 toward Chemo‐Photothermal Therapy

A Versatile Prodrug Strategy to In Situ Encapsulate Drugs in MOF Nanocarriers: A Case of Cytarabine‐IR820 Prodrug Encapsulated ZIF‐8 toward Chemo‐Photothermal Therapy

Biodegradable Gelatin Methacryloyl Microneedles for Transdermal Drug Delivery

Rational Design of Rapidly Separating Dissolving Microneedles for Precise Drug Delivery by Balancing the Mechanical Performance and Disintegration Rate

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