Synthesis and characterization of hydrogel films of carboxymethyl tamarind gum using citric acid

Mali, Kailas K.; Dhawale, Shashikant C.; Dias, Remeth J.

doi:10.1016/j.ijbiomac.2017.07.058

Cited by 90 publications

(38 citation statements)

References 35 publications

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“…The retardation of drug release is associated with the swelling of the drug-loaded hydrogel film. The swelling of hydrogel film increased the thickness of film from which drug gets diffused in to bulk of dissolution medium [34] .…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Citric Acid Crosslinked Carboxymethyl Cellulose-based Composite Hydrogel Films for Drug Delivery

Mali¹,

Dhawale²,

Dias³

et al. 2018

pharmaceutical-sciences

104

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Mali et al.: Carboxymethyl cellulose-based hydrogel films for drug deliveryThe objective of this study was to synthesize and characterize citric acid crosslinked hydrogel films of carboxymethyl cellulose-tamarind gum for topical drug delivery. The hydrogel films were characterized by attenuated total reflectance-Fourier-transform infrared spectroscopy, solid-state 13 C-nuclear magnetic resonance spectroscopy and differential scanning calorimeter. The prepared hydrogel films were evaluated for the carboxyl content and equilibrium swelling ratio. Moxifloxacin hydrochloride was loaded into these hydrogel films and drug release was monitored in the phosphate buffer pH 7.4. Haemolysis assay was used to study biocompatibility of hydrogel films. Results of the attenuated total reflectance-Fourier-transform infrared spectroscopy, solid-state 13 C-nuclear magnetic resonance and differential scanning calorimeter confirmed the formation of citric acid-crosslinked hydrogel films. Total carboxyl content of hydrogel film was found to be increased when polymer ratio and amount of citric acid was increased. In contrast, swelling of hydrogel film was found to be decreased with increase in polymer ratio and amount of citric acid. Batch B1 showed highest drug loading with non-Fickian release mechanism. All remaining batches showed nonFickian release behavior with diffusion coefficient greater than 0.5. Results of haemolysis assay indicated that the citric acid crosslinked carboxymethyl cellulose-tamarind gum hydrogels were safe to be used in drug delivery. These results indicated that the citric acid crosslinked carboxymethyl cellulose-tamarind gum composite hydrogel film has the potential to be used in topical novel drug delivery systems.

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Section: Resultsmentioning

confidence: 99%

“…In brief, pre-weighed hydrogel films (~200 mg) were placed in 20 ml aqueous solution of MH (5 mg/ml) for 2 h and hydrogel films were dried in hot air oven at 40° for 24 h [34] . To determine the amount of drug loading, MH-loaded hydrogel film was cut into small pieces, weighed and immersed in 50 ml water.…”

Section: Drug Loading and In Vitro Releasementioning

confidence: 99%

Citric Acid Crosslinked Carboxymethyl Cellulose-based Composite Hydrogel Films for Drug Delivery

Mali¹,

Dhawale²,

Dias³

et al. 2018

pharmaceutical-sciences

104

View full text Add to dashboard Cite

show abstract

“…The low value of percentage hemolysis for hydrogel film can be attributed to the higher hydrophilicity of polymer matrix which decreases polymer-RBC interactions and lowers disruption of RBCs. [32] The observed percentage hemolysis was found to be less than the permissible limit 5% [20] indicating hemocompatibility of hydrogel dressings.…”

Section: Hemolysis Assaymentioning

confidence: 95%

“…[17] Tamarind polysaccharide is promising excipient, which is being used and investigated for the preparation of various dosage forms. [15,[18][19][20][21][22] The presence of hydroxyl groups in TG makes it suitable for the preparation of physically [23] or chemically [24] cross-linked hydrogels.…”

Section: Research Articlementioning

confidence: 99%

Untitled

Mali¹

2018

AJP

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Aim: The objective of this study was to develop and evaluate carboxymethylcellulose (CMC) and tamarind gum (TG)-based citric acid cross-linked vancomycin-loaded hydrogel dressing for wound healing. Materials and Methods: CMC and TG are known for its biocompatibility and biodegradability and hence selected for preparation of hydrogel dressings. The hydrogel films were characterized by attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy, solid-state 13 C-nuclear magnetic resonance (13 C-NMR) spectroscopy, differential scanning calorimeter (DSC), and scanning electron microscopy (SEM). The prepared hydrogel films were evaluated for the carboxyl content and equilibrium swelling ratio. Vancomycin hydrochloride was loaded into hydrogels films and drug release was studied in the phosphate buffer pH 7.4. The hemolysis assay was used to study the biocompatibility of hydrogel films. The wound healing activity of optimized hydrogel film was studied in the albino mice of either sex. Results and Discussion: The results of ATR-FTIR, solid-state 13 C-NMR, DSC, and SEM confirmed the formation of citric acid cross-linked hydrogel films. The total carboxyl content of hydrogel film was found to be increased when polymer ratio and amount of cross-linker was increased. The prepared hydrogel dressing showed pH-dependent swelling and swelling was decreased significantly with increase in the concentration of TG and cross-linker. Optimized hydrogel dressing batch HD1 exhibited highest drug loading with non-Fickian drug release. Hydrogel dressings were found to be hemocompatible and exhibited wound healing activity in mice. Conclusion: It can be concluded that the citric acid cross-linked polysaccharide-based hydrogel dressings have potential application in the development of topical drug delivery systems for treatment of the wound.

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“…The main chain consists of β-D (1-4)-linked glucopyranosyl units and side chain with a single xylopyranosyl unit linked to every second, third, and fourth D-glucopyranosyl units via α-D (1-6) linkage. TaG is safe (noncarcinogenic) and biocompatible, which results in its extensive applications with diverse pharmaceutical dosage forms [90,[124][125][126]. Sangnim et al formulated clindamycin-incorporated nanofibrous patches composed of polyvinyl alcohol (PVA) and TaG via electro-hydrodynamic atomization [127].…”

Section: Gums-based Nanofibrous Formsmentioning

confidence: 99%

Recent Advances in Natural Gum-Based Biomaterials for Tissue Engineering and Regenerative Medicine: A Review

et al. 2020

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The engineering of tissues under a three-dimensional (3D) microenvironment is a great challenge and needs a suitable supporting biomaterial-based scaffold that may facilitate cell attachment, spreading, proliferation, migration, and differentiation for proper tissue regeneration or organ reconstruction. Polysaccharides as natural polymers promise great potential in the preparation of a three-dimensional artificial extracellular matrix (ECM) (i.e., hydrogel) via various processing methods and conditions. Natural polymers, especially gums, based upon hydrogel systems, provide similarities largely with the native ECM and excellent biological response. Here, we review the origin and physico-chemical characteristics of potentially used natural gums. In addition, various forms of scaffolds (e.g., nanofibrous, 3D printed-constructs) based on gums and their efficacy in 3D cell culture and various tissue regenerations such as bone, osteoarthritis and cartilage, skin/wound, retinal, neural, and other tissues are discussed. Finally, the advantages and limitations of natural gums are precisely described for future perspectives in tissue engineering and regenerative medicine in the concluding remarks.

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Synthesis and characterization of hydrogel films of carboxymethyl tamarind gum using citric acid

Cited by 90 publications

References 35 publications

Citric Acid Crosslinked Carboxymethyl Cellulose-based Composite Hydrogel Films for Drug Delivery

Citric Acid Crosslinked Carboxymethyl Cellulose-based Composite Hydrogel Films for Drug Delivery

Untitled

Recent Advances in Natural Gum-Based Biomaterials for Tissue Engineering and Regenerative Medicine: A Review

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