Synthesis and Characterization of Hydrogel of Chitosan-Poly (N-Vinyl-2-Pirrolidone) (PVP)- Alginate for Ibuprofen Release

Afriani, Kartini; Budikania, Tri Sutanti

doi:10.21776/ub.jpacr.2020.009.03.558

Cited by 5 publications

(5 citation statements)

References 21 publications

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“…The CH 3 symmetrical deformation mode is represented by bands at 1418 and 1381 cm −1 . The CS saccharide structure is characterized by bands at 1150 and 897 cm −1 49 …”

Section: Resultsmentioning

confidence: 99%

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Fabrication of pH‐sensitive double cross‐linked sodium alginate/chitosan hydrogels for controlled release of amoxicillin

Feyissa

Gupta

Edossa

et al. 2023

Polymer Engineering & Sci

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This research aims to fabricate a potent pH‐sensitive double network sodium alginate/chitosan hydrogel cross‐linked by calcium chloride (CaCl2) and glutaraldehyde for the controlled release of amoxicillin (AMX) to mitigate gastrointestinal tract bacterial infection. The effect of polymer ratios and CaCl2 concentration is investigated by the developing porosity, gel fraction, and swelling ratios in simulated physiological fluids of different pH and in vitro biodegradation at pH 7.4. Interaction between the polymers with the formation of cross‐linked structures, amorphous phase nature, good thermal stability, and transition from porous, fibrous structures to highly densified structures of the hydrogels is revealed by scanning electron microscopy, Fourier‐transform infrared spectroscopy, x‐ray diffraction, and thermogravimetric analysis. Based on structure–property relationships, a sodium alginate/chitosan hydrogel (weight ratio 75:25) cross‐linked with 2% CaCl2 and soaked in 2% (25 wt/v% solutions) glutaraldehyde is chosen for the incorporation of 200 mg of the drug. The percent cumulative AMX release in physiological fluids and the drug release kinetics using different models reveal that the most appropriate Korsmeyer–Peppas model suggests AMX release from the matrix follows diffusion coupled with swelling‐regulated time‐dependent non‐Fickian transport process related to hydrogel erosion. Excellent antibacterial against Streptococcus pyogenes and Escherichia coli is exhibited by this composition.

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“…The CH 3 symmetrical deformation mode is represented by bands at 1418 and 1381 cm −1 . The CS saccharide structure is characterized by bands at 1150 and 897 cm −1 49 …”

Section: Resultsmentioning

confidence: 99%

“…The CS saccharide structure is characterized by bands at 1150 and 897 cm À1 . 49 Figure 5B shows the spectra of hydrogels B1-C1 to B1-C5 as a function of CS content. The Na O band characteristic of SALG at ca.…”

Section: Ftir Analysismentioning

confidence: 99%

Fabrication of pH‐sensitive double cross‐linked sodium alginate/chitosan hydrogels for controlled release of amoxicillin

Feyissa

Gupta

Edossa

et al. 2023

Polymer Engineering & Sci

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“…In the FTIR spectrum of pristine PVP (Figure 4(a)), the broad band between 3600 and 3000 cm −1 corresponds to the O-H stretching vibration of moisture due to the polymer's inherent hygroscopic nature. 36 Peaks at 2923, 1655, 1495, 1423, 1285, and 1024 cm −1 are assigned to CH 2 symmetric stretching, -C=O stretching vibrations, C-H bending, CH 2 wagging, frequency of C-N, and out-of-plane rings of CH 2 bending (rocking), respectively. 36 The peak at 1655 cm −1 also infers the hygroscopic nature of the polymer.…”

Section: Resultsmentioning

confidence: 99%

“…36 Peaks at 2923, 1655, 1495, 1423, 1285, and 1024 cm −1 are assigned to CH 2 symmetric stretching, -C=O stretching vibrations, C-H bending, CH 2 wagging, frequency of C-N, and out-of-plane rings of CH 2 bending (rocking), respectively. 36 The peak at 1655 cm −1 also infers the hygroscopic nature of the polymer.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and characterization of chitosan/polyvinylpyrrolidone hydrogels for controlled amoxicillin release

Feyisa,

Gupta,

Edossa

et al. 2023

Journal of Bioactive and Compatible Polymers

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Hybrid crosslinked hydrogel-based drug delivery systems can deliver therapeutically beneficial drug release effects through controlled release on a temporal and spatial scale. Due to their tuneable physicochemical properties and the ability to prevent drug degradation, these systems facilitate different physicochemical interactions that control drug release. This research aims to synthesize a potent pH-sensitive crosslinked chitosan/polyvinylpyrrolidone hydrogel using different ratios of both the polymers and varying the glutaraldehyde crosslinking agent amount by the solution casting technique for controlled amoxicillin-release properties to mitigate gastrointestinal tract bacterial infection. The effect of polymer ratios and glutaraldehyde amount is investigated by the developing porosity, gel fraction, and extent of swelling in simulated physiological fluids of pH 1.2, 6.8, and 7.4 and in vitro biodegradation at pH 7.4. Interaction between the polymers with the formation of crosslinked structures, good stability, amorphous phase nature, and honeycomb-like structures of the hydrogels is revealed by Fourier-transform infrared spectroscopy, thermogravimetric analysis, X-ray diffraction, and scanning electron microscopy. Based on these properties, a chitosan/polyvinylpyrrolidone hydrogel (ratio of 60:40) crosslinked with 600 μL glutaraldehyde in 8 g of the polymers displaying adequate swelling in acidic to basic pH and in vitro biodegradation at pH 7.4 is chosen for the in situ loading of 200 mg of the drug amoxicillin. The cumulative drug release in simulated physiological fluids and the drug release kinetics using different models show that the best-fit Korsmeyer-Peppas model suggests amoxicillin release from the matrix follows diffusion and swelling-controlled time-dependent non-Fickian transport related to hydrogel erosion. This composition displays excellent antimicrobial activity against Streptococcus pyogenes and Escherichia coli.

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“…The FTIR spectrum of pristine PVP shows a broad band between 3600 and 3000, corresponding to the O-H stretching vibration of moisture due to the polymer's inherent hygroscopic nature [49]. Peaks at 2923, 1655, 1495, 1423, 1285, and 1024 cm −1 are assigned to CH2 symmetric stretching, -C=O (confirm it) stretching vibrations, C-H bending, CH2 wagging, frequency of C-N, and out-ofplane rings of CH 2 bending (rocking), respectively [49,50]. The peak at 1655 cm −1 also shows the hygroscopic nature of the polymer.…”

Section: Ftir Analysis Figures 4(a)mentioning

confidence: 99%

Fabrication of pH-Responsive Chitosan/Polyvinylpyrrolidone Hydrogels for Controlled Release of Metronidazole and Antibacterial Properties

Feyissa

Edossa

Bedasa

et al. 2023

International Journal of Polymer Science

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This research focused on preparing hydrogels with controlled drug release properties to control gastrointestinal tract bacterial infection. Chitosan (CS) and polyvinylpyrrolidone (PVP) were used as the base polymers, with the CS component crosslinked by glutaraldehyde for hydrogel preparation using the solution casting technique. The effect of varying glutaraldehyde content in the hydrogels was characterized by the extent of swelling in simulated physiological fluids of pH 1.2, 6.8, and 7.4; the development of porosity; and gel fraction. Functional groups and covalent and hydrogen bonds formed, thermal stability, phase structure, and morphology were characterized by Fourier-transform infrared spectroscopy, thermogravimetric analysis, X-ray diffraction, and scanning electron microscopy. The results show that the components in the hydrogels have good compatibility and formed honeycomb-like structures. In vitro studies confirmed that the hydrogels have good biodegradability at pH 7.4. Based on these properties, a CS/PVP hydrogel of the ratio of 60 : 40 crosslinked with 600 μL glutaraldehyde was selected for the in-situ loading of 200 mg of the drug metronidazole (MTZ). The hydrogel was characterized for cumulative drug release in the simulated physiological fluids and drug release kinetics using different models and for its antibacterial activity. The best-fit Korsmeyer–Peppas model suggests that MTZ release followed diffusion and swelling-controlled time-dependent non-Fickian transport related to hydrogel erosion. This hydrogel displays enhanced antimicrobial activity against Staphylococcus aureus, and Escherichia coli showed substantial inhibition zones indicating the produced CS/PVP hydrogels are promising candidates for controlled drug release applications.

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Synthesis and Characterization of Hydrogel of Chitosan-Poly (N-Vinyl-2-Pirrolidone) (PVP)- Alginate for Ibuprofen Release

Cited by 5 publications

References 21 publications

Fabrication of pH‐sensitive double cross‐linked sodium alginate/chitosan hydrogels for controlled release of amoxicillin

Fabrication of pH‐sensitive double cross‐linked sodium alginate/chitosan hydrogels for controlled release of amoxicillin

Synthesis and characterization of chitosan/polyvinylpyrrolidone hydrogels for controlled amoxicillin release

Fabrication of pH-Responsive Chitosan/Polyvinylpyrrolidone Hydrogels for Controlled Release of Metronidazole and Antibacterial Properties

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