Synthesis and characterization of hydrogels from cellulose acetate by esterification crosslinking with EDTA dianhydride.

Senna, André M.; Novak, Katia M.; Carmo, Janaína Braga do; Botaro, Vagner Roberto

doi:10.5151/chempro-15bmos-bmos2013_20131014122211

Cited by 13 publications

(30 citation statements)

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“…e HAC-EDTA in question is a polymer having crosslinked chains, and its polymer chains are linked together by chain segments joined by covalent primary forces developed by Senna et al [12]. e material is composed of cellulose acetate with the degree of substitution (GS) 2 and 5 and EDTAD, with cellulose acetate being the main base of the hydrogel.…”

Section: Hac-edta Synthesismentioning

confidence: 99%

“…e formation of polymer networks is determined by the type of synthesis performed and by the presence of reagents capable of branching the molecular structures, thus forming the polymer networks, which can be formed by crosslinking or functional group polymerization (endlinking) [11,12].…”

Section: Introductionmentioning

confidence: 99%

“…Absence of these salts in the culture medium can affect cell adhesion and cell division and impair the progress of the experiment. One of the possibilities of deficiency of this free calcium and magnesium in the culture medium can be attributed to materials whose structure is crosslinked with other materials, with a chelating effect, such as the hydrogel used in the development of HAC-EDTA [12], which has EDTA.…”

Section: Introductionmentioning

confidence: 99%

“…e hydrogels that present metric networks with the capacity to retain water inside the porous structure [12] show possibilities in biomedical applications; for example, hydrogels based on natural polymers, including cellulose, are of particular interest due to their hydrophilicity, biocompatibility, and biodegradability [30].…”

Section: Introductionmentioning

confidence: 99%

“…HAC-EDTA is a new polymeric material developed in our research group [12]. It presents features of high degree of swelling, amphoteric character, and low production value, has more attractive physical, chemical, and thermodynamic properties, and has possible application as a biomaterial, which must be evidenced in this work as something unheard of, since this material was never used as a biomaterial until now.…”

Section: Introductionmentioning

confidence: 99%

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Chelating Effect of Cellulose Acetate Hydrogel Crosslinked with EDTA Dianhydride Used as a Platform for Cell Growth

Melero

Senna

Domingues

et al. 2019

Advances in Materials Science and Engineering

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The use of biomaterials capable of achieving controlled release of drugs or chemical and physical interactions with living organisms causes these new materials to be studied in depth to better target their future applications. An example of this is the use of materials that have in their physical structure elements with chelating effects, capable of interacting with the ions and cations present in the cell culture media, drugs, and other elements capable of interacting with the human body. In this work, cellulose acetate hydrogel (HAC) crosslinked with EDTAD (ethylenediaminetetraacetic acid dianhydride) showed a significant chelating effect capable of altering the adhesion of mesenchymal cells in the first days of in vitro tests. This result became our main question in this work, and by using new cell viability assays, it was verified that the hydrogel interacted with the culture medium, removed the salts present, such as Ca2+ and Mg2+, and promoted a decrease in the amount of cells adhered to the material but not cell death. After saturation of Ca2+ and Mg2+, we obtained an improvement in cell adhesion. Electrochemical impedance spectroscopy (EIS) results also verified the dynamics of linked or mobile loads in the volume and interface regions of HAC-EDTA and the presence of characteristic bands related to the interaction between calcium and magnesium present in the culture medium with HAC-EDTA. The DMA traction test showed that there was no dynamic-mechanical change in the structure of the material at temperatures between 20 and 60°C, which is ideal for this studied biomaterial. The purpose of these tests is to aid in the characterization of future biomaterials, where the physicochemical interaction of some of them is often confused with a false cytotoxicity, which in fact may only be an easily identifiable and adaptable structural feature.

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Section: Hac-edta Synthesismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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