Synthesis and characterization of hydrogels based on grafted chitosan for the controlled drug release

Sokker, H. H.; Ghaffar, A. M. Abdel; Gad, Yasser H.; Aly, A. S.

doi:10.1016/j.carbpol.2008.06.015

Cited by 110 publications

(53 citation statements)

References 25 publications

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“…The FTIR spectra of the blends membranes with chitosan and PVA are shown in Figure 1 which shows bands at 893 and 1155 cm -1 confirmed the presence of pyranose ring and saccharine structure of chitosan 11,27,29 . The bands at 1644 and 1322 cm -1 are characteristics of chitin and chitosan moieties, respectively and are reported as amide I and amide III peaks.…”

Section: Fourier Transform Infrared Spectroscopic (Ftir) Analysismentioning

confidence: 93%

“…C-H vibrational stretching of alkyl groups has been observed between 3000-2840 cm -1 . A broad band at 3600-3200 cm -1 ( Figure 1a) was due to -NH symmetric vibration and -OH stretching of inter and intra-molecular hydrogen bonding [29][30][31][32] . It was also observed that the broad region between 3600-3200 cm -1 was increased in all blended films as compared to the chitosan and PVA.…”

Section: Fourier Transform Infrared Spectroscopic (Ftir) Analysismentioning

confidence: 99%

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An Investigation of Ac Impedance and Dielectric Spectroscopic Properties of Conducting Chitosan-silane Crosslinked-poly (Vinyl Alcohol) Blended Films

et al. 2015

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The films of chitosan (CS)-silane crosslinked-poly(vinyl alcohol) (PVA) with different weight % were prepared. The effect on conductivity of CS/PVA blended films due to change in the concentration of PVA and temperature was investigated by impedance spectroscopy and showed good conductance properties. The complex impedance plots revealed single semicircular arcs indicating the bulk contribution to overall electrical behavior of all synthesized samples. The ac conductivity obeyed the Jonscher's power law for all samples in the frequency range of 2 kHz to 2 MHz. The ionic conductivity of the films was increased with the increase in temperature for all synthesized samples which showed an increase in the number of effective charge carriers while it was decreased at a specific higher temperature for each film. The observed activation energy for CP4, CP8 and CP10 were 0.431, 0.610 and 0.425 eV, respectively. These properties showed that the films were promising materials to be employed for conducting properties.

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Section: Fourier Transform Infrared Spectroscopic (Ftir) Analysismentioning

confidence: 93%

Section: Fourier Transform Infrared Spectroscopic (Ftir) Analysismentioning

confidence: 99%

An Investigation of Ac Impedance and Dielectric Spectroscopic Properties of Conducting Chitosan-silane Crosslinked-poly (Vinyl Alcohol) Blended Films

et al. 2015

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“…Natural polymers usually present higher biocompatibility compared to synthetic polymers, as they undergo enzyme controlled biodegradation by human enzymes like lysozyme and produce biocompatible byproducts. [8] On the other hand, synthetic polymers are chemically stronger than natural ones, because of hydrolysable moieties with slower degradation rate. This feature provides more prolonged lifetime in human body.…”

Section: Classification Of Hydrogelsmentioning

confidence: 99%

Preparation of Chitosan Hydrogels and Its Pharmaceutical Drug Delivery

Salvador¹

2017

WJPPS

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A considerable amount of work has been published on chitosan and its potential use in drug delivery systems. Chitosan has a cationic character because of its primary amino groups. These primary amino groups are responsible for properties such as controlled drug release, mucoadhesion, in situ gellation, transfection, permeation enhancement and efflux pump inhibitory properties. Due to chemical modifications, most of these properties can even be further improved. Chitosan Hydrogel has been recently developed serve as semi synthetic or synthetic extra cellular matrix to provide an amenable environment for cellular adherence and cellular remodeling in three dimensional structures mimicking that of natural cellular environment. Additionally, hydrogels have the capacity to carry small molecule drugs and/or proteins, growth factors and other necessary components for cell growth and differentiation. In the context of drug delivery, hydrogels can be utilized to localize drugs, increase drugs concentration at the site of action and consequently reduce off-targeted side effects. This review classifies hydrogels and their method of preparation.

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“…[1][2][3][4][5] In particular, hydrogels occupies an important portion among biomaterials due to their hydrophilicity and ability to absorb water without losing their viscoelasticity. 6 Swelling behavior, mechanical properties, and biocompatiblility of the hydrogels should be evaluated for use of biomedical purposes.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Hydrogel Contact Lens Containing Alginate

Lee¹,

Kim²,

Cho

2011

Bulletin of the Korean Chemical Society

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Biocompatible hydrogels from 2-hydroxyethyl methacrylate (HEMA) monomer containing various amount of alginate in the presence and absence of hydrophilic methacrylic acid (MAA) were synthesized in order for biomedical application. The antimicrobial effect and interaction with proteins for hydrogels were investigated in this study. MAA was introduced because it was expected to increase the amount of water content in the polymer which is an important factor for biocompatibility, and alginate was expected to enhance the antimicrobial activity. The antimicrobial effect against S. aureus and E. coli increased for all hydrogels as the amount of alginate and MAA contained. Presence of MAA further enhances the antimicrobial effect. Amount of adsorption of bovine serum albumin (BSA) increased with increasing concentration of alginate whether MAA was present or not. Contrarily, the amount of lysozyme was not affected with increasing alginate concentration in the absence of MAA, while it decreased in the presence of MAA.

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Synthesis and characterization of hydrogels based on grafted chitosan for the controlled drug release

Cited by 110 publications

References 25 publications

An Investigation of Ac Impedance and Dielectric Spectroscopic Properties of Conducting Chitosan-silane Crosslinked-poly (Vinyl Alcohol) Blended Films

An Investigation of Ac Impedance and Dielectric Spectroscopic Properties of Conducting Chitosan-silane Crosslinked-poly (Vinyl Alcohol) Blended Films

Preparation of Chitosan Hydrogels and Its Pharmaceutical Drug Delivery

Antimicrobial Hydrogel Contact Lens Containing Alginate

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