Synthesis and characterization of hydrogels containing biodegradable polymers

Abstract

BACKGROUND: Amphiphilic block and graft copolymers constitute a very interesting class of polymers with potential for biomedical applications, due to their special characteristics, which derive from the combination of properties of hydrophilic and hydrophobic moieties. In this work, the synthesis and biodegradation of poly(2hydroxyethyl methacrylate)-graft-poly(L-lactide) are studied. RESULTS:The graft copolymers were synthesized using the macromonomer technique. In a first step, methacryloyl-terminated poly(L-lactide) macromonomers were synthesized in a wide molecular weight range using different catalysts. Subsequently, these macromonomers were copolymerized with 2-hydroxyethyl methacrylate in order to obtain a graft copolymer. These new materials resemble hydrogel scaffolds with a biodegradable component. The biodegradation was studied in hydrolytic and enzymatic environments. The influence of different parameters (molecular weight, crystallinity, ratio between hydrophilic and hydrophobic components) on the degradation rate was investigated.CONCLUSION: Based on this study it will be possible to tailor the release properties of biodegradable materials. In addition, the materials will show good biocompatibility due to the hydrophilic poly(2-hydroxyethyl methacrylate) hydrogel scaffold. This kind of material has potential for many applications, like controlled drug-delivery systems or biodegradable implants.

Ionic liquid functionalized polylactide by cationic polymerization: Synthesis and stabilization of carbon nanotube suspensions

“…If R‐OH is used as initiator, group R‐ is introduced into polymer as head‐group. This approach was used for the synthesis of functionalized polylactides in which R‐ is reactive polymerizable group 3–15…”

Construction of paclitaxel-loaded poly (2-hydroxyethyl methacrylate)-g-poly (lactide)- 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine copolymer nanoparticle delivery system and evaluation of its anticancer activity

“…The method used was different from other previously reported methods. 11,12,14 In the present work, pNP was selected for activation of the PHEMA-PLA copolymer (Schema 1B) according to a previously reported method, with some changes. 34 The content of 4-nitrophenyl carbonate moieties could be determined during the reaction course.…”

“…[5][6][7][8][9] However, the mechanical properties of PHEMA hydrogels do not fit the requirements for many structural applications. Therefore, amphiphilic polymers consisting of PHEMA and biodegradable polyesters, ie, poly(L-lactide) (PLLA), 10,11 poly(D,L-lactide), [12][13][14] poly(glycolic acid), poly(ε-caprolactone), 15,16 and polystyrene, have been synthesized. 17 These copolymers can be obtained through ring-opening polymerization, atom transfer radical polymerization, 11,18,19 A 2 B 2 PCl/acrylate miktoarm polymers, 20 or use of a protective group, eg, a trimethylsilyl moiety.…”

Copolumers obtained by grafting of vinyl monomers on starch - influence of amines on synthesis and degradation processes in environment

“…U ovim sistemima moguće je pratiti uticaj različitih mikroorganizama i enzima na biodegradaciju polimernih materijala. Kalemljeni kopolimeri 2-hidroksietil-metakrilata i L-laktida podvrgnuti su enzimskoj degradaciji u laboratorijskim uslovima korišćenjem proteinaze K [293]. U slučaju visoko kristaliničnog polimera (> 60 %), nakon 192 h, enzimski je degradirano 34 % polimera.…”