Synthesis and Characterization of Hydroxyapatite Powder by Sol-Gel Method for Biomedical Application

Agrawal, K. N.; Singh, Gurdev; Puri, D.; Prakash, S.

doi:10.4236/jmmce.2011.108057

Cited by 83 publications

(65 citation statements)

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“…By controlling synthesis conditions carefully, the sol morphology can be directed towards weakly branched polymeric systems or to particulate systems [7]. Important process parameters include water content, the solvent, the catalyst used and its concentration and type of alkoxide used [4,10,11].…”

Section: Introductionmentioning

confidence: 99%

“…Unlike conventional glass, which is a viscous fluid that results from the fusion of SiO 2 at high temperature, sol-gel-derived silica is obtained at mild conditions [3] compatible with the stability of most bioactive compounds. The sol-gel process is capable of generating materials with controlled surface properties and pore structures between 1 -500 nm [4][5][6][7]. The matrix of the silica thus formed can be exploited for immobilization of biomolecules or cations, inorganic membranes and support for catalysts [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

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Sol-Gel-Derived Porous Silica: Economic Synthesis and Characterization

Essien¹,

Olaniyi²,

Adams³

et al. 2012

JMMCE

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Porous silica was synthesized via the sol-gel process using clay obtained locally from Ijero-Ekiti in Ekiti State, Nigeria and compared with silica synthesized under similar conditions from sodium metasilicate (Na 2 SiO 3 ) obtained comercially. The clay was initially refluxed with sodium hydroxide (NaOH) for 2 hours to extract SiO 2 to form Na 2 SiO 3 , which was subsequently hydrolyzed to form a gel. The gel obtained was washed with deionized water to get rid of impurities, dried and calcined at 800˚C for 3 hours. The obtained silica powders were characterized using atomic absorption spectrophotometer, Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD) and scanning electron microscopy (SEM). Results showed that the vibrational modes and diffraction patterns of the silica derived from commercial Na 2 SiO 3 and that prepared from clay were similar containing pure amorphous SiO 2 . The morphology of the commercially obtained silica showed better arrangement of particles and exhibited slightly lesser porosity (62.4%) compared to that derived from clay which had a porosity of 65.5%. The result indicates that clay has a potential for use as an environmentally safe and economic starting material for preparing porous silica instead of high quality precursors.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sol-Gel-Derived Porous Silica: Economic Synthesis and Characterization

Essien¹,

Olaniyi²,

Adams³

et al. 2012

JMMCE

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show abstract

“…However, the production is still complex, challenging and expensive [45]. The sol-gel technologies are newer methods for the synthesis of nanophase sHAs from Ca and P precursor combinations [11,46]. A colloidal solution is converted into an amorphous gel, which is dried and solidified and later heated up to 600°C.…”

Section: Characterization and Preparation Of Synthetic Hamentioning

confidence: 99%

Molecular, Cellular and Pharmaceutical Aspects of Synthetic Hydroxyapatite Bone Substitutes for Oral and Maxillofacial Grafting

Götz¹,

Papageorgiou²

2017

CPB

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Bone grafts are widely used for augmentation procedures in oral and maxillofacial surgery, with autogenous bone being the gold standard. Recently, the focus of research has shifted towards synthetic bone substitutes, as no second surgery is needed and large quantities of graft can easily be provided. Within the broad range of bone substitutes, synthetic hydroxyapatite has drawn much attention, as they are considered to be biocompatible, non-immunogenic, osteoconductive and osteoinductive. Scope of this review is to summarize existing knowledge concerning the molecular, cellular and pharmaceutical aspects of synthetic bone substitutes for oral and maxillofacial grafting.

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“…Hence, some researchers have attempted to synthesis HAp nanoparticles with a unique attention. Nano particles HAp (Nano HAp) can imitate the measurements of the constituent segments of regular tissues which improve the osteoblasts attachment and resorption of long haul tissue designed inserts [11][12][13]. Additionally, the layout option is a standout amongst the most adaptable and helpful technique, as it is exceptionally powerful in delivering particles having the size in the scope of nanometers together with a limited level of agglomeration and a controlled morphology [14,15].…”

Section: Introductionmentioning

confidence: 99%

Greener Synthesis of Nano Hydroxyapatite using Fatty acids template for the application of Tissue Engineering Nano Hydroxyapatite: Fatty acids Synthesis and Characterizations

Sumathra¹,

Rajan²

2017

J Mol Pharm Org Process Res

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Nano-hydroxyapatite (nano-HAp) is significant import as a bio-ceramic material for use in orthopedic applications because of its comparability in size, crystallography and substance creation with human hard tissue. In this present study, the biologically high interest of nano-HAp was synthesized as green template mode approaches using the various fatty acids like linoleic acid, lauric acid, and oleic acid. The influence of the fatty acid for the formations nanoHAp structure and nature of fatty acid during synthesis was investigated. The nano-HAp functionality, crystallinity, and morphology were determined by FTIR, XRD, and SEM techniques, respectively. The biocompatibility of HAp on MG63 cell line was confirmed by in vitro MTT assay method. The in-vitro studies showed better biocompatibility and cell proliferation results on the template assist synthesized nHAP. These results indicate that nHAp form the green methodology could be a promising material for bone tissue engineering.

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Synthesis and Characterization of Hydroxyapatite Powder by Sol-Gel Method for Biomedical Application

Cited by 83 publications

References 1 publication

Sol-Gel-Derived Porous Silica: Economic Synthesis and Characterization

Sol-Gel-Derived Porous Silica: Economic Synthesis and Characterization

Molecular, Cellular and Pharmaceutical Aspects of Synthetic Hydroxyapatite Bone Substitutes for Oral and Maxillofacial Grafting

Greener Synthesis of Nano Hydroxyapatite using Fatty acids template for the application of Tissue Engineering Nano Hydroxyapatite: Fatty acids Synthesis and Characterizations

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