Synthesis and Characterization of Hydroxyapatite Nanoparticle

Abstract

In this research, hydroxyapatite (HA) nano-size powder was synthesized using wet chemical precipitation technique under atmospheric pressure where calcium hydroxide (Ca(OH) 2 ) and ortho-phosphoric acid (H 3 PO 4 ) were used as precursors. Distilled water was used as a diluting media for the reaction and sodium hydroxide (NaOH) was used to control the initial pH. The initial pH values, reaction temperature and calcined temperature play an important role in the morphology on HA as well as the phase formation and degree of crystallinity. Nano HA powder has been studied at different initial pH value which is between 9.00 to 11.00, reaction temperature from 80 °C to 100 °C and calcined temperature at 700 °C to 800 °C. The optimum initial pH value was found at pH 10.00, reaction temperature at 100 °C and calcined temperature was at 800 °C. The crystallographic properties were evaluated by X-ray diffraction (XRD), Fourier Transform Infrared (FTIR) and Field Emission Scanning Microscope (FESEM). The Design Expert version 9.0.2 with statistical and graphical analysis of the result, by using analysis of variance (ANOVA) was applied to optimize variable in the process of synthesis of HA. Based on analysis of variance (ANOVA) that has been perform, calcined temperature was to be influential variables on mass of HA with value of probability less than 0.05. Keywords: hydroxyapatite, chemical precipitation, crystallinity, morphology, optimization AbstrakDalam kajian ini, nanozarah hidroksiapatit (HA) dihasilkan melalui kaedah pemendakan di bawah tekanan atmosfera di mana kalsium hidroksida (Ca(OH) 2 ) dan asid orto fosforik (H 3 PO 4 ) merupakan larutan asas bagi penyediaan HA. Air suling digunakan sebagai agen pelarut dalam menyediakan larutan asas bagi proses pemendakan ini. Larutan natrium hidroksida di gunakan bagi mengawal nilai pH. Nilai pH, suhu tindak balas dan suhu relau merupakan faktor penting dalam pencirian dan penghabluran nanozarah HA. Nanozarah HA disediakan pada nilai pH antara 9.00 hingga 11.00, suhu tindak balas 80 °C hingga 100 °C dan suhu relau pada 700 °C hingga 800 °C. Pencirian nanozarah HA di uji menggunakan X-ray Difractometer (XRD), Inframerah Transformasi Fourier (FTIR), dan Mikroskop Pengimbas Pancaran Medan (FESEM). Perisian Design-Expert 9.0.2 digunakan untuk menganalisis data dan pengoptimuman penghasilan mendakan HA. Berdasarkan analisis varian (ANOVA) yang dilakukan, suhu relau merupakan pemboleh ubah yang mempengaruhi berat HA dengan nilai kemungkinan kurang dari 0.05.Kata kunci: hikdroksiapatit, mendakan bahan kimia, penghabluran, pencirian, pengoptimuman IntroductionTissue disease and defect, and bone disease are serious health condition that can affect the life for those who suffer on it. Since last four decades, various revolution has been introduced in order to make improvement of the uses of

Graphene Oxide-Modified Hydroxyapatite Nanocomposites in Biomedical Applications: A Review

“…new preparation methods continue to be developed [37]. In recent years, methods applied to HA synthesis have included precipitation techniques [38], sol-gel approaches, and hydrothermal, multiple emulsion, biomimetic deposition and electrodeposition techniques [39] and polymeric sponge template [40].…”

New Solid-Solutions of Substitution Strontium (Sr) for Lead (Pb) in Apatite Structure

“…According to the solid-state method, the lead sodium apatite Pb 8 Na 2 (PO 4 ) 6 was synthesized at 500 °C for three days, then the temperature was increased to 1000 °C for 12 hours, and finally it was decreased to 500 °C. 28 In other works, [29][30][31] lead sodium apatite compounds Pb (8-x) Ln x Na 2 (PO 4 ) 6 O (x/2) and Pb (8-x) Ln x Na 2 (GO 4 ) 6 (2-x/2) O (x/2) were obtained by solidstate method with a large variety of rare earth element substitutions (La, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Tm, Yb, Y) for lead (Pb). The calcined time ranged from 7 hours at 900 °C to 50-250 hours at 800 °C.…”