Synthesis and characterization of hydroxyapatite nanoparticles and their application in protein adsorption

Vázquez-Hernández, F.; Mendoza‐Barrera, C.; Altúzar, V.; Meléndez‐Lira, M.; Santana-Aranda, M. A.; Olvera, M. de la L.

doi:10.1016/j.mseb.2010.03.011

Cited by 27 publications

(13 citation statements)

References 16 publications

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“…Bioactive molecules often exhibit a high binding affinity for calcium phosphate surfaces. Generally the adsorption equilibrium of such drugs strongly interacting with an apatitic surface can be satisfactorily described by a Langmuir isotherm, a behavior similar to that presented by proteins and aminoacids [119,200,219,220,250,251], as explained in Section 2. Negatively-charged molecules are considered to bind to calcium sites and positively-charged ones to phosphate sites.…”

Section: Drug Delivery and Surface Functionalizationmentioning

confidence: 99%

“…The images show that amelogenin was bound more strongly to certain crystal faces suggesting a more specific role for this protein in the control of crystal morphology and growth [219]. Vázquez-Hernández et al studied the adsorption of bovine serum albumin (BSA) and fibrinogen (FGN) on nanocrystalline apatite synthesized by hydrothermal method [220]. In this case, AFM images showed ovoid-shaped adsorbed BSA molecules whereas adsorbed FGN molecules were elongated with dimensions around 525 nm Â 130 nm.…”

mentioning

confidence: 99%

“…In this case, AFM images showed ovoid-shaped adsorbed BSA molecules whereas adsorbed FGN molecules were elongated with dimensions around 525 nm Â 130 nm. Therefore, they concluded that both proteins are denatured in the adsorption process since they change their original shape and size [220].…”

mentioning

confidence: 99%

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Progress on the preparation of nanocrystalline apatites and surface characterization: Overview of fundamental and applied aspects

Gómez‐Morales¹,

Iafisco

Delgado-López³

et al. 2013

Progress in Crystal Growth and Characterization of Materials

241

268

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International audienceNanocrystalline calcium phosphate apatites constitute the main inorganic part of hard tissues, and a growing focus is devoted to prepare synthetic analogs, so-called "biomimetic", able to precisely mimic the morphological and physico-chemical features of biological apatite compounds. Both from fundamental and applied viewpoints, an accurate characterization of nanocrystalline apatites, including their peculiar surface features, and a deep knowledge of crystallization aspects are prerequisites to attempt understanding mineralization phenomena in vivo as well as for designing innovative bioactive materials that may then find applications in bone tissue engineering, either as self-supported scaffolds and fillers or in the form of coatings, but also in other domains such as drug delivery or else medical imaging. Also,interfacial phenomena are of prime importance for getting a better insight of biomineralization and for following the behavior of biomaterials in or close to their final conditions of use. In this view,both adsorption and ion exchange represent essential processes involving the surface of apatite nanocrystals, possibly doped with foreign elements or functionalized with organic molecules of interest. In this review paper, we will address these various points in details based on a large literature survey. We will also underline the fundamental physico-chemical and behavioral differences that exist between nanocrystalline apatites (whether of biological origin or their synthetic biomimetic analogs) and stoichiometric hydroxyapatite

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Section: Drug Delivery and Surface Functionalizationmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Progress on the preparation of nanocrystalline apatites and surface characterization: Overview of fundamental and applied aspects

Gómez‐Morales¹,

Iafisco

Delgado-López³

et al. 2013

Progress in Crystal Growth and Characterization of Materials

241

268

View full text Add to dashboard Cite

show abstract

“…Calcium substitution allows the addition of metallic sites to the material and the anion substitutions such as PO 4 3-groups by HPO 4 2-and CO 3 2-and OH − by F -, modify the surface properties and the thermal stability of the material [7]. Various chemical synthesis methods including hydrothermal [8], sol-gel [9], sonochemical [10], precipitation [11], microemulsion [12], microwave [13], mechanochemical [14] and surfactant-assisted approach [15] are available for the preparation of HA nanostructures. The sol-gel method is preferred due to its low synthesis temperature, high product purity, homogenous molecular mixing and the ability to generate nano sized particles compared to other alternatives [16].…”

Section: Introductionmentioning

confidence: 99%

Thermal stability of a modified sol-gel derived hydroxyapatite nanopowders

Herradi¹,

Bali²,

Khaldi³

et al. 2017

IOP Conf. Ser.: Mater. Sci. Eng.

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“…Numbers of materials such as collagen,11, 12 gelatin,9, 13 polyethylene glycol,14 polylactic copolymers,15 hydroxyapatite (HA) [Ca 10 (PO 4 ) 6 (OH) 2 ],16, 17 and tricalcium phosphate [Ca 3 (PO 4 ) 2 ]18 have been studied for their suitability as protein carrier. These biomaterials have great potential as drug carriers, and unlike protein carriers derived from natural sources, synthetic biomaterials do not induce immunogenic response.…”

Section: Introductionmentioning

confidence: 99%

Effect of macromer synthesis time on the properties of the resulting poly(β‐amino ester) degradable hydrogel

Hawkins¹,

Puleo²,

Hilt³

2011

J of Applied Polymer Sci

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Poly(b-amino ester) biodegradable hydrogels are common in biomedical applications because of their tunable properties and similarities to natural soft tissue. Previous work has shown property adjustments through the choice of monomers, the ratio between monomers and the addition of a crosslinking component. Here, we show that the reaction time for the creation of the macromer can affect the resulting hydrogel properties, and thus provides another method of tuning properties. Macromer was created through the reaction of isobutylamine with poly(ethylene glycol) diacrylate (n ¼ 400). The reaction progress was analyzed using IR and GPC analysis. Hydrogels were created through UV photopolymerization from macromers synthesized for 24, 36, and 48 h. The degradation, compressive moduli, and swelling were measured in an aqueous solution. All showed significant differences between hydrogels of different macromer synthesis times. These differences likely stem from the incomplete macromer synthesis reaction and resulting PEG-rich regions in hydrogels from shorter synthesis times. These regions will not readily degrade, but do increase the mechanical properties and extent of swelling.

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Synthesis and characterization of hydroxyapatite nanoparticles and their application in protein adsorption

Cited by 27 publications

References 16 publications

Progress on the preparation of nanocrystalline apatites and surface characterization: Overview of fundamental and applied aspects

Progress on the preparation of nanocrystalline apatites and surface characterization: Overview of fundamental and applied aspects

Thermal stability of a modified sol-gel derived hydroxyapatite nanopowders

Effect of macromer synthesis time on the properties of the resulting poly(β‐amino ester) degradable hydrogel

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