Synthesis and characterization of iridium chloride complexes: I. Use of N-alkylphenothiazine drugs as ligands

Abstract

Iridium complexes of N-alkylphenothiazines have been prepared in MeOH. The polynuclear complexes obtained have been characterized by elemental analyses, magnetic susceptibilities, molar conductivities, thermogravimetric analysis and spectral data. The molecular formulae of the new complexes are as follows: [Ir3(LH)4Cllo]C1 z'xMeOH, where L = chlorpromazine (CP), promethazine (PM) or ethopropazine (EP), and x = 1 for CP and 2 for PM or EP; [Ir(TFH2)2C14] [IrC161" MeOH, where TF = trifluoperazine; and [Ir3(TRH)2C1 ll(MeOH)]CI'MeOH and [Ir4(TRH)3ClIs], where TR=thioridazine. The complexes are diamagnetic in nature. Tentative structures are proposed for the complexes.

Synthesis and Characterization of Transition Metal Complexes of Chlorpromazine

“…Especially, in the free CP.HCl ligand, the broad singlet which occurs far down field (δ 10.80), attributable to the exocyclic (R 3 NH) + proton, has shifted upfield on complexation indicating a change in this proton environment. This indirectly supports the existence of intramolecular hydrogen bonding between (R 3 NH) + and X -of the MX 3 moiety [12,15,24]. Crystals of sufficient quality required to permit x-ray crystallographic analysis of the complexes could not be grown.…”

“…In the uncomplexed CPHCl, the presence of a broad band in the 2000-2730 cm -1 range is assigned to the interaction of the quaternary ammonium ion, (R 3 NH) + ion with a halide ion [12][13][14][15]21,22]. In the IR spectra of the metal-CP.HCl complexes, this band has shifted with diminished intensity suggesting that the exocyclic N atom of the alkylamino group is indirectly involved in coordination with the metal center.…”

“…A band observed in the 3000-2800 cm -1 region in the spectrum of CP.HCl may be assigned to the heterocyclic nitrogen atom carrying an alkyl amine side chain [21,22]. This band of CP.HCl shows a shift upon complexation suggesting its coordination to the metal(II) center [10][11][12][13][14]. In addition, CdBr 2 and HgBr 2 complexes show a broad band in the 3250-3560 cm -1 region, supporting the hydrogen bonded OH interactions of the water of hydration.…”

“…In addition, CdBr 2 and HgBr 2 complexes show a broad band in the 3250-3560 cm -1 region, supporting the hydrogen bonded OH interactions of the water of hydration. The Hg(II) complex spectrum shows that bands in the 600-700 cm -1 and 715-740 cm -1 regions, attributable to the heterocyclic C-S-C modes, undergo a shift, suggesting heterocyclic sulfur atom as a coordination site [12,15,22]. The 1 H NMR data for the ligand, CP.HCl, and its complexes are presented in Table 5.…”

“…The NPTZ derivatives find extensive applications in the field of medicine as antipsychotic, anxiolytic, antiemetic and inodilationdrugs [1][2][3]. Previously, some studies of transition metal-NPTZ complexes have been reported by several workers [4][5][6][7][8][9][10][11][12][13][14][15][16].…”