Synthesis and Characterization of Iron Oxide Embedded Hydroxyapatite Bioceramics

Abstract

A homogeneous dispersion of nano iron oxide (IO) crystallites inside the hydroxyapatite (HA) particles was achieved by a co‐precipitation method. This highly stable colloidal dispersion of magnetic nano composite (HAIO) was made without the use of any surfactants. The in situ generated dispersion of the composite powders showed submicron HA particles with ~5 nm iron oxide inside. The phase analysis results showed the presence of hydroxyapatite (HA) and iron oxide with no tertiary phase. The enhancement of relative peak intensities with increased percentage of iron oxide phase in X‐ray diffraction analysis suggests the formation of iron oxide together with HA without affecting the phase purity of the latter, which is important when the biological behavior of HA is concerned. This also confirms the quantitative nature of the precipitated nanocomposites. The High Resolution Transmission Electron Microscope (HRTEM) of the composite shows elongated crystal flakes or platelike surfaces of HA crystallites having particle sizes in the range 70–100 nm. HRTEM with XRD analysis matches HAIO only with iron oxide particles of Magnetite (Fe3O4) and HA phases. The FTIR data confirm that the introduction of iron oxide did not produce any considerable change in the chemical structure of HA.

Simple and Rapid Synthesis of Magnetite/Hydroxyapatite Composites for Hyperthermia Treatments via a Mechanochemical Route

“…Ansar et al [31] synthesized Fe 3 O 4 /HA composite particles with characteristics similar to those of our composites using a simple method. In their synthesis method, however, after the formation of Fe 3 O 4 nanoparticles by coprecipitation, they employed heating treatments at 343 K for 1 h and then at 353 K for 1 h to synthesize HA.…”

“…The use of magnetic Fe-doped HA is the most effective solution to this problem [28–30], but embedding Fe 3 O 4 nanoparticles into HA matrices can also reduce the long-term toxic effects. Such Fe 3 O 4 -embedded HA materials are conventionally synthesized by mixing HA powder with Fe 3 O 4 nanoparticles, which are prepared sequentially or individually prior to mixing [22–24,31]. However, conventional synthesis methods have some disadvantages: the reaction times required for the complete formation of HA and Fe 3 O 4 are relatively long, and subsequent heat treatments performed to achieve aging and crystallization are required.…”

Inert atmosphere processing of hydroxyapatite in the presence of lithium iron phosphate

“…On the other side, there are no enough reliable data on the mechanism by which Fe-compounds influence HAp sinterability. The addition of Fe to HAp was considered from the point of view of imparted magnetic response [9,14]; furthermore, formation of metallic, especially Ti-Fe inclusions, in a brittle ceramic matrix was found to be useful for fracture resistance improvement [15]. Generally, achieving a certain level of multifunctionality within HAp-based bioceramics for specific purposes could make a progress in applications of HAp-based materials.…”

Magnetically recoverable iron oxide–hydroxyapatite nanocomposites for lead removal

“…A number of synthetic methodologies have been described over the last few years (Ansar et al 2012;Mir et al 2010;Muzquiz-Ramos et al 2010;Singh et al 2012;Wakiya et al 2010). However, only two recent reports are related to remediation methods, taking advantage either of photocatalytic activities of the materials for organic degradation (Yang et al 2010) or of the apatite affinity for lead ions (Dong et al 2010).…”