Synthesis and characterization of MAA-based molecularly-imprinted polymer (MIP) with D-glucose template

Yanti, Yanti; Nurhayati, ‪Tati; Royani, Idha; Widayani, _; Khairurrijal, Khairurrijal

doi:10.1088/1742-6596/739/1/012143

Cited by 27 publications

(13 citation statements)

References 25 publications

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“…The XRD patterns of NIP and MIP before and after AEA removal are shown in Figure in which each has different peaks approximately at 16.66, 16.03, and 17.21°, respectively. The intensity decrement before and after AEA removal demonstrated interaction between MMA and AEA, although shifting of the diffraction peak to larger 2θ before and after AEA removal indicated increased interlayer spacing along with weak interaction between AEA and the monomer . In further inspections of the diffraction peak, the obtained full width at half-maximums (FWHMs) of NIP and MIP before and after AEA removal were 4.49, 6.97, and 16.99°, respectively.…”

Section: Resultsmentioning

confidence: 61%

“…The peaks at 1391.31 and 2958.27 cm –1 denoted O–H binding vibration and O–H stretching and confirmed the presence of −COOH group during the interaction among MMA, EGDMA, and AEA. Moreover, the peaks at 1165.4 and 1728.21 cm –1 confirmed the existence of C–O and CO stretching in the EGDMA cross-linker . The variation in the peak intensity at 2958.27 cm –1 (O–H stretching) supported the interaction of the O–H group of MMA with the O–H group of AEA to form H bonds, which was highly visible in the FTIR graph of MIP before AEA removal .…”

Section: Resultsmentioning

confidence: 67%

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Dual-Layered Nanomaterial-Based Molecular Pattering on Polymer Surface Biomimetic Impedimetric Sensing of a Bliss Molecule, Anandamide Neurotransmitter

et al. 2020

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In this endeavor, a novel electrochemical biosensor was designed using multiwall carbon nanotubes (MWCNTs)- and nickel nanoparticles (NiNPs)-embedded anandamide (AEA) imprinted polymer. The NiNPs so synthesized were mortared with MWCNTs and molecularly imprinted polymer (MIP), which enhanced sensitivity and selectivity of the developed sensor, respectively. The characterization methods of AEA-based MIP included X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), and Brunauer–Emmett–Teller (BET) analysis, which supported the successful synthesis of the polymer. Electrochemical studies of fabricated sensor were performed using cyclic voltammetry (CV) and electrochemical impedance spectroscopy in potentiostatic mode (PEIS). In this first phase of AEA-specific sensor development, MWCNT/NiNP/MIP@SPE was found to successfully discriminate between different concentrations of AEA. The developed sensing platform demonstrated a 100 pM–1 nM linear range with a 0.01 nM detection limit (LOD), 0.0149 mA/pM sensitivity, and 50% stability within 4 months. The sensor demonstrated selectivity toward AEA: although acetylcholine (ACh) and dopamine acted as strong interfering components because of their chemical similarity, the spiked AEA samples demonstrated ∼90% recoveries. Hence, our results have passed the first step in AEA detection at home, although with a clinical setup, future advancement is still required.

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Section: Resultsmentioning

confidence: 61%

Section: Resultsmentioning

confidence: 67%

Dual-Layered Nanomaterial-Based Molecular Pattering on Polymer Surface Biomimetic Impedimetric Sensing of a Bliss Molecule, Anandamide Neurotransmitter

et al. 2020

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“…Kehadiran dua puncak yang signifikan pada gugus fungsi C=O (ulur) di bilangan gelombang 1690-1760 cm -1 dan gugus fungsi C-O (ulur) pada bilangan gelombang 1000-1300 cm -1 menunjukkan keberadaan dari EDMA. Gugus fungsi C-O (ulur) pada 1046 cm -1 berasal dari rantai monomer [16]. Pada bilangan gelombang 1180-1359 cm -1 terdapat gugus fungsi C-N (amina, ulur) [17] dan pada bilangan gelombang 650-750 cm -1 terdapat gugus fungsi N-H (amina sekunder), yang merupakan kelompok fungsional amina sebagai ciri khas gugus fungsi karbaril [17,18].…”

Section: A Fourier Transform Infraredunclassified

Optimasi Ukuran dan Jumlah Pori yang Terbentuk Pada Molacularly Imprinted Polymer (MIP) Nano Karbaril (C12H11NO2)

Aprilia¹,

Koryanti²,

Royani³

2020

Positron

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Telah dilakukan pembuatan molecular imprinted polymer (MIP) nano karbaril dengan metode cooling-heating. Pembuatan MIP nano karbaril bertujuan untuk mendapatkan material sensor yang potensial dalam aplikasinya. Dalam penelitian ini, bahan aktif karbaril di-milling dengan variasi waktu 10 menit dan 15 menit. Pada proses polimerisasi melibatkan templat nano karbaril, methacrylic acid (MAA) sebagai monomer fungsional, ethylene glycol dimathacrylate (EDMA) sebagai crosslinker, benzoil peroksida (BPO) sebagai inisiator, dan acetonitril sebagai pelarut yang disintesis menggunakan metode cooling-heating. Dengan cara yang sama, non-imprinted polymer (NIP) juga dibuat sebagai polimer kontrol. NIP merupakan polimer yang dibuat dengan komposisi dan cara yang sama dengan MIP, namun tidak ditambahkan nano karbaril sebagai zat aktif. Pembuangan templat pada proses ekstraksi sangat berperan penting untuk menghasilkan material sensor yang baik. MIP, polimer, dan NIP yang dihasilkan di karakterisasi menggunakan Fourier transform infrared (FTIR) dan sampel terbaik dideteksi lebih lanjut dengan uji x-ray diffraction (X-RD), dan scanning electron microscope (SEM). Hasil FTIR menunjukkan bahwa gugus fungsi spesifik nano karbaril pada NIP tidak tampak bila dibandingkan dengan spektra MIP, dan terjadi penurunan persen transmitansi pada polimer dan peningkatan % transmitansi pada MIP. Hal ini menjelaskan bahwa terjadi penurunan konsentrasi nano karbaril pada MIP setelah proses ektraksi. Hasil X-RD menunjukkan ukuran kristal yaitu 9,16 Å. Hasil SEM menunjukkan bahwa jumlah pori tercetak dengan ukuran ≤100 nm yaitu 383 pori. Data ini mengindikasikan bahwa MIP nano karbaril potensial untuk diaplikasikan sebagai material sensor.

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“…Monomer yang digunakan adalah asam metakrilat yang dapat berinteraksi kuat dengan template dalam berbagai interaksi (ikatan hidrogen donor-akseptor, ikatan dipol -dipol, dan van der Waals). 8 Asam metakrilat (MAA) biasanya digunakan sebagai monomer dalam imprinting non -kovalen yang mampu berinteraksi dengan gugus fungsional seperti ester, asam, amida, dan amina. 9 Selain itu, kombinasi asam metakrilat sebagai monomer dengan pelarut non polar sebagai porogen akan menghasilkan ikatan hidrogen dan interaksi elektrostatik yang berpengaruh terhadap imprinting (pencetakan).…”

Section: Pendahuluanunclassified

Characterization of Imprinted Polymer of Diazepam With Methacrylic Acid and Hydroxyethyl Methacrylate Monomer in Chloroform for Selective Adsorption of Diazepam

Ferdinand

Pratiwi

Hasanah

2020

IJPST

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Diazepam is a benzodiazepine class usage is regulated nationally or globally. These drugs can be used to regulate sleep patterns or sedative-hypnotic drugs because it has a calming effect. Monitoring the abuse of diazepam requires a sensitive analysis methods that required the preparation of selective methods. One of the methods that are currently developing is Moleculary Imprinted Polymer-Solid Phase Extraction (MI-SPE). In this research, step being performed include determination of the association constant, synthesis sorbent of Imprinted Polymer (IP) diazepam by bulkpolymerization method with diazepam as a template, chloroform as porogen, two kind of monomer methacrylic acid (MAA) and hydroxyethyl methacrylate (HEMA) as functional monomer. Templates extracted from polymer followed by evaluation of adsorption ability test, a test of capacity and selectivity of the polymer, and also the characterization of the IP using Fourier Transform Infra-Red (FTIR),and Scanning Electron Microscope (SEM). The results showed that IP diazepam with MAA monomer has 7.95 x 10-5 mg/g of capacity, it is better than capacity of IP diazepam monomer HEMA with 7.47x 10-6 mg/g. Selectivity of IP diazepam MAA monomer has an IF value which is 2.13, which is better than IP HEMA with 1.21. In addition, IP diazepam MAA monomer more heterogenous than its Non Imprinted Polymer (NIP).Keywords: Chloroform, Diazepam, HEMA, Methacrylic acid, MI-SPE.

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Synthesis and characterization of MAA-based molecularly-imprinted polymer (MIP) with D-glucose template

Cited by 27 publications

References 25 publications

Dual-Layered Nanomaterial-Based Molecular Pattering on Polymer Surface Biomimetic Impedimetric Sensing of a Bliss Molecule, Anandamide Neurotransmitter

Dual-Layered Nanomaterial-Based Molecular Pattering on Polymer Surface Biomimetic Impedimetric Sensing of a Bliss Molecule, Anandamide Neurotransmitter

Optimasi Ukuran dan Jumlah Pori yang Terbentuk Pada Molacularly Imprinted Polymer (MIP) Nano Karbaril (C12H11NO2)

Characterization of Imprinted Polymer of Diazepam With Methacrylic Acid and Hydroxyethyl Methacrylate Monomer in Chloroform for Selective Adsorption of Diazepam

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