Synthesis and characterization of maghemite nanoparticles for hyperthermia applications

Múzquiz-Ramos, E.M.; Guerrero-Chávez, V.; Macías-Martínez, B.I.; Lopez‐Badillo, C.M.; Garcı́a-Cerda, L.A.

doi:10.1016/j.ceramint.2014.08.083

Cited by 80 publications

(36 citation statements)

References 13 publications

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“…Test. The induction heating test was carried out at different concentrations of MagNPs, MagNPs-VTMS, and MagNPs-PVCL ( Figure 5), which are into the reported used range for biomedical applications [21,22]. The results show that MagNPs produced higher heating than the others even Journal of Nanomaterials at low concentration (4 mg/mL).…”

Section: Heatingmentioning

confidence: 97%

“…The heat generated decreases in MagNPs-PVCL nanocomposites in comparison with MagNPs, it is important to note that the polymer in the nanocomposite provides colloidal stability of the samples and it favors the control of the temperature rise in magnetic hyperthermia. Therefore, it is possible to obtain appropriated heating values using MagNPs-PVCL nanocomposites at low magnetic induction time and low concentration in comparison with previous magnetic materials used for hyperthermia treatment [21,23].…”

Section: Heatingmentioning

confidence: 99%

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Synthesis of Poly(N-vinylcaprolactam)-Grafted Magnetite Nanocomposites for Magnetic Hyperthermia

Morfin-Gutierrez

Meléndez‐Ortiz²,

Puente-Urbina

et al. 2018

Journal of Nanomaterials

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In this study, the synthesis, characterization, and application of poly(N-vinylcaprolactam)-grafted magnetite nanocomposites for magnetic hyperthermia are reported. Superparamagnetic magnetite nanoparticles (MagNPs) with sizes in the range of 10–16 nm were synthesized by the coprecipitation method and then functionalized with vinyltrimethoxysilane (VTMS). MagNPs-VTMS coated with poly(N-vinylcaprolactam) (PNVCL) were prepared by free radical polymerization. The obtained materials were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), vibration sample magnetometry (VSM), and Fourier transform infrared spectroscopy (FT-IR). The heating ability was evaluated under a magnetic field using a solid state induction heating equipment at 10.2 kA/m and 362 kHz. The MagNPs-PNVCL nanocomposites showed a behavior close to superparamagnetic materials, which is appropriated for magnetic hyperthermia treatment; in concentrations of 8 mg/mL, they were able to heat up, increasing the temperature up to 42°C in a period of time lower than 10 minutes.

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Section: Heatingmentioning

confidence: 97%

Section: Heatingmentioning

confidence: 99%

Synthesis of Poly(N-vinylcaprolactam)-Grafted Magnetite Nanocomposites for Magnetic Hyperthermia

Morfin-Gutierrez

Meléndez‐Ortiz²,

Puente-Urbina

et al. 2018

Journal of Nanomaterials

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“…Although MNPs have given good results in preclinical and clinical trials, they can be coated with other materials to improve their proprieties [5][6][7][8]. A coat of polymeric materials is preferred because of their proprieties of biodegradation and biocompatibility [9].…”

Section: Introductionmentioning

confidence: 99%

“…Although there is a common use of PEG in medicine [10,11], the interaction of the PEG molecule with the human body is still being studied [12][13][14]. According to several authors, coating MNPs with PEG improves the MNP blood circulation and their biocompatibility; it reduces their surface charge and maintains the magnetic characteristics of the MNPs [1,5,9]. On the other hand, Tween 80 has been proposed by some authors such as a coat in nanoparticles because of its ability to be targeted into the brain after an intravenous injection.…”

Section: Introductionmentioning

confidence: 99%

Magnetite Nanoparticles Coated with PEG 3350-Tween 80: In Vitro Characterization Using Primary Cell Cultures

et al. 2020

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Some medical applications of magnetic nanoparticles require direct contact with healthy tissues and blood. If nanoparticles are not designed properly, they can cause several problems, such as cytotoxicity or hemolysis. A strategy for improvement the biological proprieties of magnetic nanoparticles is their functionalization with biocompatible polymers and nonionic surfactants. In this study we compared bare magnetite nanoparticles against magnetite nanoparticles coated with a combination of polyethylene glycol 3350 (PEG 3350) and polysorbate 80 (Tween 80). Physical characteristics of nanoparticles were evaluated. A primary culture of sheep adipose mesenchymal stem cells was developed to measure nanoparticle cytotoxicity. A sample of erythrocytes from a healthy donor was used for the hemolysis assay. Results showed the successful obtention of magnetite nanoparticles coated with PEG 3350-Tween 80, with a spherical shape, average size of 119.2 nm and a zeta potential of +5.61 mV. Interaction with mesenchymal stem cells showed a non-cytotoxic propriety at doses lower than 1000 µg/mL. Interaction with erythrocytes showed a non-hemolytic propriety at doses lower than 100 µg/mL. In vitro information obtained from this work concludes that the use of magnetite nanoparticles coated with PEG 3350-Tween 80 is safe for a biological system at low doses.

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“…The monodomain condition of magnetic particles is characterized by uniformity of magnetization at any values and directions of field H, possibility of existence of domains not only in solid-state of ferro-and ferrimagnetic alloys and compounds, but also in liquid media (suspensions and colloids). In many practically important cases, the functional application of nanoparticles (directional transport of medicinal preparations to target organs and cells, recognition and decontamination of viruses, adsorption [4,5,10,16,17]) is carried out in liquid media. Besides, liquid is the most preferable form of magnetosensitive medicinal preparations for introduction in an organism [10].…”

Section: Introductionmentioning

confidence: 99%

Adsorption of cis-dichlorodiammineplatinum by nanostructures based on single-domain magnetite

et al. 2015

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Magnetosensitive nanocomposites on the basis of monodomain magnetite Fe 3 O 4 /meso-2,3-dimercaptosuccinic acid, Fe 3 O 4 /c-aminopropyltriethoxysilane, Fe 3 O 4 / polyacrylamide, Fe 3 O 4 /hydroxyapatite were synthesized. Size distribution of magnetite nanoparticles in ensemble and their magnetic properties were studied. It has been shown that the magnetization curve of the liquid containing monodomain magnetite has a form that is characteristic for superparamagnetics, and its calculations in the framework of Langeven's paramagnetism theory match satisfactorily to the experimental results. The highest adsorption parameters were observed for magnetosensitive nanocomposites Fe 3 O 4 / polyacrylamide and Fe 3 O 4 /c-aminopropyltriethoxysilane. Prospects of the studied nanostructures for medicobiological and technical applications as adsorbents of cis-dichlorodiammineplatinum were shown.

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Synthesis and characterization of maghemite nanoparticles for hyperthermia applications

Cited by 80 publications

References 13 publications

Synthesis of Poly(N-vinylcaprolactam)-Grafted Magnetite Nanocomposites for Magnetic Hyperthermia

Synthesis of Poly(N-vinylcaprolactam)-Grafted Magnetite Nanocomposites for Magnetic Hyperthermia

Magnetite Nanoparticles Coated with PEG 3350-Tween 80: In Vitro Characterization Using Primary Cell Cultures

Adsorption of cis-dichlorodiammineplatinum by nanostructures based on single-domain magnetite

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