Synthesis and characterization of magnetite/hydroxyapatite tubes using natural template for biomedical applications

Abstract

Inorganic nanotubes have attracted much attention during the last few decades for its potential applications in the field of regenerative medicine and controlled drug delivery. In the present work, we have designed and synthesized magnetite hydroxyapatite micro and nanotubes. The first step is the formation of magnetite (Fe 3 O 4) tubes on natural template followed by hydroxyapatite (HAp) bioceramic coated on the Fe 3 O 4 tubes. HAp improves the biocompatibility and stability of the prepared tubes. Sintering at 900 • C improves the crystalline stability of nanotubes and removes the natural template. X-ray diffraction, N 2 adsorption-desorption studies (BET), thermogravimetric analysis, differential scanning calorimetry, optical micrographs, field emission scanning electron microscope and transmission electron microscope studies were carried out to confirm the structural and morphological analysis of prepared magnetic tubular structure.

A brief review on hydroxyapatite production and use in biomedicine

“…Microwave heating generates heat within the samples, reducing reaction time and increasing nucleation rate and growth [95,98,[174][175][176]. HAp can be obtained with differentiated structures, such as nanostructured mesoporous microspheres [177], mesoporous lozenges [178], and hollow microspheres [45], using various organic additives, such as amino acids [179,180], surfactants [160,[180][181][182][183][184][185], or natural origin substances [186,187]. The combination of biochemical and hydrothermal procedures by incorporating an aqueous medium into the system can accelerate the kinetic processes that normally limit the rate of reaction in a conventional mechanochemical method.…”

“…HAp has been obtained in form of nanoblasts [182,183,188], nanofibers [189][190][191], nanowires [184], and nanotubes [151,186]. These structures are said to be 1D and have a size of ≤100 nm in at least one of their dimensions, resulting in high surface activity and an ultrafine structure, similar to the mineral of hard tissues [41].…”

Magnetic Hydroxyapatite Nanoparticles in Regenerative Medicine and Nanomedicine

“…The study found that the coating with HA enhanced the biocompatibility and stability of the produced nanotubes. This HA-coated magnetite tubular structure has been found to be a viable option for the application of magnetic hyperthermia treatment when combined with an appropriate drug loading method [ 145 ].…”

Development of a multicellular 3D-bioprinted microtissue model of human periodontal ligament-alveolar bone biointerface: Towards a pre-clinical model of periodontal diseases and personalized periodontal tissue engineering

“…The mixture was stirred at room temperature for 5 h, and then kept still for about 24 h at room temperature. 38 HAp-coated MNPs were separated from non-magnetic HAp by magnetic decantation and then dried at 40 °C for 24 h. All chemicals were purchased from Sigma–Aldrich (St. Louis, MO, USA), unless otherwise stated.…”