Synthesis and characterization of methoxy poly(ethylene glycol)-b-poly(DL-lactide-co-glycolide-co-ε-caprolactone) di block copolymers: Effects of block lengths and compositions

Baimark, Yodthong; Srisa-ard, Mangkorn; Threeprom, Jirasak; Molloy, Robert; Punyodom, Winita

doi:10.1515/epoly.2007.7.1.1609

Cited by 3 publications

(3 citation statements)

References 26 publications

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“…Methoxy poly(ethylene glycol)-b-poly(D,L-lactide) diblock copolymer (MPEG-b-PDLL) with number-average molecular weight and molecular weight distribution of 73,600 g/mol and 1.88, respectively, was synthesized as previously described (Baimark, Srisa-ard, Threeprom, Molloy, & Punyodom, 2007b). MPEG with molecular weight of 5000 g/mol and stannous octoate were used as an initiating system.…”

Section: Methodsmentioning

confidence: 99%

Preparation of nanocomposite chitosan/silk fibroin blend films containing nanopore structures

Niamsa

Srisuwan

Baimark

et al. 2009

Carbohydrate Polymers

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Section: Methodsmentioning

confidence: 99%

Preparation of nanocomposite chitosan/silk fibroin blend films containing nanopore structures

Niamsa

Srisuwan

Baimark

et al. 2009

Carbohydrate Polymers

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“…The chitosan solution was prepared using 1% (v/v) acetic acid aqueous solution as the solvent. The MPEG-b-PDLLG diblock copolymer with DLL/G ratios of 100/0 and 85/15 mol%, designed as MPEG-b-PDLL and MPEG-b-PDLLG, respectively were synthesized as described in our previous work [4]. The preparation of nanocomposite films was typically described as follows.…”

Section: Methodsmentioning

confidence: 99%

Preparation and Drug Release Studies of Chitosan/Methoxy Poly(Ethylene Glycol)-<i>b</i>-Poly(D,L-Lactide-<i>co</i>-Glycolide) Nanocomposite Films for Use as Controlled Release Drug Delivery

Niamsa

Srisa-ard

Srisuwan

et al. 2008

AMR

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Nanocomposite chitosan-based films incorporated with drug-loaded methoxy poly(ethylene glycol)-b-poly(D,L-lactide-co-glycolide) diblock copolymers (MPEG-b-PDLLG) nanoparticles were prepared by forming drug-loaded nanoparticles in chitosan solution before suspension-solution film casting. Salicylic acid was used as a poorly-water soluble model drug. The nanocomposite films with DLL/G ratios of 100/0 and 85/15 mol% and chitosan/diblock copolymer/drug ratios of 80/1/1, 80/2/2 and 80/4/4 (w/w) were prepared and investigated. The sizes of drug-loaded nanoparticles into the chitosan films were approximate or less than 100 nm. Nanopores were observed in the resulted chitosan films incorporated with drug-loaded nanoparticles when the diblock copolymer ratio was increased up to 2. Number and size of the nanopores increased as increasing the diblock copolymer ratio. Only the nanocomposite films with chitosan/diblock copolymer/drug ratio of 80/1/1 (w/w) showed slower drug release than the chitosan film.

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“…In the last five decades, there has been a markedly increased interest in synthetic bioadsorbable polymers for medical devices such as surgical sutures, vascular scaffolds, nerve guides, plates and screws, drug-eluting stents, etc. − Aliphatic polyesters such as poly( l -lactide) (PLL), poly( d -lactide) (PDL), poly( d , l -lactide) (PDLA), poly( rac -lactide), polyglycolide (PGA), poly(ε-caprolactone) (PCL), poly(δ-valerolactone) (PVL), and their other high-molecular-weight co- or terpolymers such as poly( l -lactide- co -ε-caprolactone) (PLC) and poly( l -lactide- co -ε-caprolactone- co -glycolide) (PLCG) were found to have a multitude of uses in medical applications. − Typically, biodegradable polyesters can be obtained via ring-opening polymerization (ROP) in the bulk . For the ROP of lactides and lactones, tin(II) 2-ethylhexanoate or stannous octoate (Sn(Oct) 2 ) has been approved for use as a food additive by the US FDA and is the most common initiator used due to its effectiveness and versatility.…”

Section: Introductionmentioning

confidence: 99%

Development of an Antimicrobial-Coated Absorbable Monofilament Suture from a Medical-Grade Poly(l-lactide-co-ε-caprolactone) Copolymer

et al. 2021

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In this study, a medical-grade poly(l-lactide-co-ε-caprolactone) (PLC) copolymer with a monomer ratio of l-lactide (L) to ε-caprolactone (C) of 70:30 mol % for use as an absorbable surgical suture was synthesized via ring-opening polymerization (ROP) using a novel soluble liquid tin(II) n-butoxide (Sn(OnC4H9)2) as an initiator. In fiber fabrication, the process included copolymer melt extrusion with a minimal draw followed by sequential controlled hot-drawing and fixed-annealing steps to obtain oriented semicrystalline fibers with improved mechanical strength. For healing enhancement, the fiber was dip-coated with “levofloxacin” by adding the drug into a solution mixture of acetone, poly(ε-caprolactone) (PCL), and calcium stearate (CaSt) in the ratio of acetone/PCL/CaSt = 100:1% w/v:0.1% w/v. The tensile strength of the coated fiber was found to be increased to ∼400 MPa, which is comparable with that of commercial polydioxanone (PDS II) of a similar size. Finally, the efficiency of the drug-coated fiber regarding its controlled drug release and antimicrobial activity was investigated, and the results showed that the coated fiber was able to release the drug continuously for as long as 30 days. For fiber antimicrobial activity, it was found that a concentration of 1 mg/mL was sufficient to inhibit the growth of Staphylococcus aureus (MRSA), Escherichia coli O157:H7, and Pseudomonas aeruginosa, giving a clear inhibition zone range of 20–24 mm for 90 days. Cytotoxicity testing of the drug-coated fibers showed a %viability of more than 70%, indicating that they were nontoxic.

show abstract

Synthesis and characterization of methoxy poly(ethylene glycol)-b-poly(DL-lactide-co-glycolide-co-ε-caprolactone) di block copolymers: Effects of block lengths and compositions

Cited by 3 publications

References 26 publications

Preparation of nanocomposite chitosan/silk fibroin blend films containing nanopore structures

Preparation of nanocomposite chitosan/silk fibroin blend films containing nanopore structures

Preparation and Drug Release Studies of Chitosan/Methoxy Poly(Ethylene Glycol)-<i>b</i>-Poly(D,L-Lactide-<i>co</i>-Glycolide) Nanocomposite Films for Use as Controlled Release Drug Delivery

Development of an Antimicrobial-Coated Absorbable Monofilament Suture from a Medical-Grade Poly(l-lactide-co-ε-caprolactone) Copolymer

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