SYNTHESIS AND CHARACTERIZATION OF Mn+2 , Co+2 , Ni+2 , Cu+2 AND Zn+2 COMPLEXES WITH 4-(2-(BENZO-1,3-DIOXOL-5-YL)-4,5-DIPHENYL-2,5- DIHYDRO-1H-IMIDAZOL-1-YL)ANILINE AND EVALUATION OF THEIR BIOLOGICAL ACTIVITY

Abstract

The aim of this work was to create new ligand complexes and evaluate their effectiveness against certain strains of bacteria. A Brucker Tensor 27co FTIR spectrophotometer was used to record the infrared spectra. Elemental analysis (C, H, N) was carried out on an AA670 atomic absorption spectrophotometer to determine mineral content, and the conductivity of PCM3 Jenway was measured to record electronic spectra. The ligand was prepared, that possessed physical constants and spectroscopic properties. The complexes [M(L)2Cl2] and [M(L)4Cl2] were also prepared, where M=Mn(II), Co(II), Ni(II), Cu(II), and Zn(II), which were synthesized by direct reaction of the above ligand with metal chlorides in (2:1) or (4:1) (Ligand : metal) molar ratio in the ethanol medium. The ligand compound 4-(2-(benzo-1,3-dioxol-5-yl)-4,5-diphenyl-2,5-dihydro1H-imidazol-1-yl)aniline (L) was obtained. The prepared complexes were shown by elemental analysis, spectroscopic studies (FTIR, UV/vis), 1H-NMR measurement, conductivity measurements, and electron spectrometry value, which indicate the presence of tetrahedral and octahedral geometry around the metal ions. The biological antibacterial activity of the compounds and complexes has been demonstrated against specific strains of G+ Staph. aureus and G− Bacillus. The bonding compound L coordinates the metal in a tetrahedral and octahedral N-M-N manner. The compound and its complexes had activity against specific strains of bacteria. The ligand (L1) and the complex (3) had a greater effect on different types of bacteria than the rest of the complexes, which had a lower efficiency rate.