Synthesis and characterization of molecularly imprinted silica mediated by Al for solid phase extraction of quercetin in<i>Ginkgo biloba</i>L.

Zhao

J of Separation Science

et al. 2016

Molecularly imprinted polymeric microspheres with a high recognition ability toward the template molecule, ellagic acid, were synthesized based on distillation-precipitation polymerization. The as-obtained polymers were characterized by scanning electron microscopy, infrared spectroscopy, and thermogravimetric analysis. Static, dynamic, and selective binding tests were adopted to study the binding properties and the molecular recognition ability of the prepared polymers for ellagic acid. The results indicated that the maximum static adsorption capacity of the prepared polymers toward ellagic acid was 37.07 mg/g and the adsorption equilibrium time was about 100 min when the concentration of ellagic acid was 40 mg/mL. Molecularly imprinted polymeric microspheres were also highly selective toward ellagic acid compared with its analogue quercetin. It was found that the content of ellagic acid in the pomegranate peel extract was enhanced from 23 to 86% after such molecularly imprinted solid-phase extraction process. This work provides an efficient way for effective separation and enrichment of ellagic acid from complex matrix, which is especially valuable in industrial production.

Section: Resultsmentioning

confidence: 58%

Preparation of ellagic acid molecularly imprinted polymeric microspheres based on distillation–precipitation polymerization for the efficient purification of a crude extract

Zhao

J of Separation Science

et al. 2016

“…Flavonoids and phenolic acids, nature compounds, are widely distributed in different parts of plants and form part of the human diet. They have been reported to have multiple biological effects, including antioxidant activity, anti‐inflammatory action, inhibition of platelet aggregation, and antimicrobial activities . Many plant extracts, like some flavonoids, polyphenols, and glycosides, possess cis ‐diol structures; however, there are very few reports on the application of boronate‐affinity materials to these kinds of compounds.…”

Section: Introductionmentioning

confidence: 99%

“…They have been reported to have multiple biological effects, including antioxidant activity, anti-inflammatory action, inhibition of platelet aggregation, and antimicrobial activities. [30,31] Many plant extracts, like some flavonoids, polyphenols, and glycosides, possess cis-diol structures; however, there are very few reports on the application of boronate-affinity materials to these kinds of compounds. Therefore, it is very important to explore the application of boronate-affinity materials in the separation and enrichment of cis-diol-containing substances in plants and their related products.…”

Section: Introductionmentioning

confidence: 99%

Facile preparation of a high‐capacity boronate‐affinity adsorbent based on low‐cost commercial supports for selective enrichment of cis‐diol‐containing biomolecules

Wang

Wei

2018

J Chinese Chemical Soc

Boronate‐affinity adsorbents have been regarded as favorable extraction adsorbents for the pretreatment of cis‐diol‐containing biomolecules owning to their specific selectivity, but most of them have low adsorption capacity and a tedious synthesis methods. In this study, a new boronate‐affinity material (PGMA@FPBA) with high adsorption capacity was synthesized via a “one‐pot” method based on a low‐cost commercial support. The PGMA@FPBA was characterized by Fourier transform infrared spectroscopy (FT‐IR), X‐ray photoelectron spectroscopy (XPS), scanning electron microscope (SEM), and nitrogen adsorption/desorption measurements. The as‐prepared adsorbent showed good selectivity, high adsorption capacity (448 μmol/g for catechol), and fast adsorption equilibration (1 min) for cis‐diol‐containing biomolecules. Subsequently, as an example for application, the obtained PGMA@FPBA was used as a dispersive solid‐phase extraction (d‐SPE) adsorbent for enrichment of quercetin in red wine. The results indicated that the facile‐prepared boronate‐affinity adsorbent has great potential application for separation and enrichment of cis‐diol‐containing biomolecules in complex samples.

“…Recently, various types of MIPs have been used as the adsorbent for solid phase extraction (SPE). These adsorbents have been widely used for the selective separation of various environmental pollutants (7)(8)(9), drugs and metabolites (10,11), as well as bioactive compounds (12)(13)(14). Thus far, conventional MIPs are prepared by bulk polymerization or precipitation polymerization (8).…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, and theoretical study of an acrylamide-based magnetic molecularly imprinted polymer for the recognition of sulfonamide drugs

et al. 2015

Abstract:In this work, a magnetic molecularly imprinted polymer (MION-MIP) was prepared for the recognition and extraction of sulfadiazine (SDZ). The acrylamide-based MIP was imprinted directly onto the surface of 3-(trimethoxysilyl)propyl methacrylate-modified magnetic iron oxide nanoparticles. The synthesized MION-MIP with a diameter about 100 nm possesses fast adsorption kinetics and high adsorption capacity. The results also indicated that a higher maximum adsorption capacity (775 μg g -1 ) was achieved by the synthesized MION-MIP. The Langmuir adsorption isotherm model was found to describe well the equilibrium adsorption data. The results from the competitive binding experiment showed that MION-MIP was not only selective toward SDZ but the adsorption of sulfamerazine was also dramatically high. SDZ and sulfamerazine have an almost similar substructure where these two compounds were only differentiated by one methyl group. To explain this result, a computational study was carried out. From a different level of calculation with semiempirical (PM3), Hartree-Fock (HF), and density functional theory (DFT) calculation, SDZ and sulfamerazine showed similar interaction energy and interaction mechanism with the acrylamide monomer. Therefore, both SDZ and sulfamerazine could have the same binding property with the MION-MIP.