Synthesis and characterization of molecularly imprinted poly(methacrylic acid)/silica hybrid composite materials for selective recognition of lincomycin in aqueous media

Abstract

A novel molecular imprinting method for the preparation of molecularly imprinted poly(methacrylic acid)/silica hybrid composite materials (MIP-HCMs) for the selective recognition of lincomycin (LIN) in aqueous media by prepolymerization and free-radical copolymerization was investigated. In this study, methacrylic acid was selected as the functional monomer, methacryloxypropyltrimethoxysilane was used as the crosslinker, and tetraethoxysilane was used as the inorganic precursor. MIP-HCM was characterized by FTIR spectroscopy, the Brunauer-Emmett-Teller method, and TGA. The selectivity of the sorbent was investigated by a batch competitive binding experiment with an aqueous LIN and clindamycin (CLI) mixture. The selectivity coefficient for LIN in the presence of CLI was 6.27, whereas the relative selectivity coefficient between LIN and CLI was 5.83. The absorption capability of MIP-HCM and the selectivity coefficient were much higher than those of the nonimprinted blank polymer.

Molecularly imprinted polymer microspheres prepared via the two‐step swelling polymerization for the separation of lincomycin

“…Such swelling/shrinking may compromise MIP's specific affinity to template molecules. In addition, the adsorption of lincomycin in aqueous solution was found heavily dependent on pH, with the maximum capacity reside at pH ~ 7 . The results in Figure were consistent with literature reports and justify the use of the largely non‐polar chloroform as the solvent in lincomycin purification processes.…”

“…After crosslinking [Figure (c)], the CC vibration at ~1637 cm −1 and the peak at ~1150 cm −1 were slightly changed . The presence of the band around 3400 cm −1 indicates that MAA has been successfully grafted to the EGDMA …”

“…MIT has found numerous applications in bio‐/pharmaceutical industries and was investigated for the separation of lincomycin. For example, Lv et al . prepared a MIP composite of polymethacrylic acid (PMMA) on a silica substrate and achieved a lincomycin/c‐lindamycin selectivity of 5.8 in aqueous solution.…”

Improved selective cholesterol adsorption by molecularly imprinted poly(methacrylic acid)/silica (PMAA–SiO2) hybrid material synthesized with different molar ratios

“…To the best of our knowledge, there are no reports available in the literature on molecularly imprinted hybrid polymers for cholesterol extraction and still few attempts have been made for the preparation of molecularly imprinted polymers selective to the other analytes. A survey of literature demonstrates that molecularly imprinted poly{(methacrylamide)-co-(vinyl trimethoxysilane)} and poly{(methacrylic acid)-co-(vinyl trimethoxysilane)} for caffeine extraction [23] and more recently, molecularly imprinted poly(methacrylic acid)/silica hybrid material have been reported for the selective extraction of lincomycin in aqueous medium and oxytetracycline in milk samples [7,24].…”

Evaluation of a new water‐compatible hybrid molecularly imprinted polymer combined with restricted access for the selective recognition of folic acid in binding assays

“…It has been very well documented that these organic−inorganic hybrid materials fabricated by incorporation of template molecules into rigid inorganic or inorganic organic networks give rise to materials with complementary properties to that observed by isolated organic or inorganic phase. Some characteristics of these materials can be cited, such as superior thermal stability, high hardness, good textural and morphological features and uniform particle sizes . In this study, folic acid was chosen as target molecule considering its relatively large size, incipient data on literature regarding synthesis of MIP for this molecule, and due to its great clinical importance to human health as a water soluble vitamin.…”