Synthesis and characterization of molecularly imprinted polymers for detection of the local anesthetic lidocaine in urine

Takahashi, Fumiki; Matsuda, Kazusane; Nakazawa, Tomoyuki; Mori, Shuki; Yoshida, Masachika; Shimizu, Ryo; Tatsumi, Hirosuke; Jin, Jiye

doi:10.1002/sscp.202200081

Cited by 7 publications

(4 citation statements)

References 35 publications

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“…Therefore, solvent extraction and solid phase extraction technique were required for selective detection. 45,46) In this study, a reaction mechanism was proposed in which codeine exhibited ECL under acidic conditions. The results of PM-ECL measurement at pH 5.0 are shown in Fig.…”

Section: Pm-ecl Behavior Of the [Ru(bpy) 3 ] 2+ /Codeine Systemmentioning

confidence: 99%

Development of a Potential-Modulated Electrochemiluminescence Measurement System for Selective and Sensitive Determination of the Controlled Drug Codeine

Takahashi,

Shimosaka,

Mori

et al. 2024

Chem. Pharm. Bull.

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Codeine is a common analgesic drug that is a pro-drug of morphine. It also has a high risk of abuse as a recreational drug because of its extensive distribution as an OTC drug. Therefore, sensitive and selective screening methods for codeine are crucial in forensic analytical chemistry. To date, a commercial analytical kit has not been developed for dedicated codeine determination, and there is a need for an analytical method to quantify codeine in the field. In the present work, potential modulation was combined with electrochemiluminescence (ECL) for sensitive determination of codeine. The potential modulated technique involved applying a signal to electrodes by superimposing an AC potential on the DC potential. When tris(2,2′-bipyridine) ruthenium(II) ([Ru(bpy) 3 ] 2 ) was used as an ECL emitter, ECL activity was confirmed for codeine. A detailed investigation of the electrochemical reaction mechanism suggested a characteristic ECL reaction mechanism involving electrochemical oxidation of the opioid framework. Besides the usual ECL reaction derived from the amine framework, selective detection of codeine was possible under the measurement conditions, with clear luminescence observed in an acidic solution. The sensitivity of codeine detection by potential modulated-ECL was one order of magnitude higher than that obtained with the conventional potential sweep method. The proposed method was applied to codeine determination in actual prescription medications and OTC drug samples. Codeine was selectively determined from other compounds in medications and showed good linearity with a low detection limit (150 ng mL 1 ).

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Section: Pm-ecl Behavior Of the [Ru(bpy) 3 ] 2+ /Codeine Systemmentioning

confidence: 99%

Development of a Potential-Modulated Electrochemiluminescence Measurement System for Selective and Sensitive Determination of the Controlled Drug Codeine

Takahashi,

Shimosaka,

Mori

et al. 2024

Chem. Pharm. Bull.

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“…MIPs are classically produced via polymerization in bulk, where a high concentration of monomers in a suitable solvent is polymerized extensively until a monolith is obtained [ 23 , 44 , 45 , 46 , 47 , 48 , 49 ]. Historically, these monoliths were then processed by grinding and fractionated via sieving to collect a regularly-sized powder which could then be exploited for further applications.…”

Section: Mip Nps Productionmentioning

confidence: 99%

“…Historically, these monoliths were then processed by grinding and fractionated via sieving to collect a regularly-sized powder which could then be exploited for further applications. This method is indeed still used, especially when quick and easy tests might be required (e.g., to assess whether a polymerization mixture would be suitable for a certain target) [ 46 , 49 ]. Nonetheless, it is extremely poorly compatible with the generation of MIP NPs.…”

Section: Mip Nps Productionmentioning

confidence: 99%

Biodegradable and Sustainable Synthetic Antibodies—A Perspective

Knowles

Poma

2023

Pharmaceutics

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Molecular imprinting technology has been around for almost a century, and we have witnessed dramatic advancements in the overall design and production of molecularly imprinted polymers (MIPs), particularly in terms of possible formats of the final products when it comes to truly resembling antibody substitutes, i.e., MIP nanoparticles (MIP NPs). Nonetheless, the overall technology appears to struggle to keep up with the current global sustainability efforts, as recently elucidated in the latest comprehensive reviews, which introduced the “GREENIFICATION” concept. In this review, we will try to elucidate if these advancements in MIP nanotechnology have indeed resulted in a sustainability amelioration. We will do so by discussing the general production and purification strategies for MIP NPs, specifically from a sustainability and biodegradation perspective, also considering the final intended application and ultimate waste management.

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“…Therefore, the World Anti-Doping Agency (WADA) has prohibited FUR in sports [5]. In doping control detection, it is imperative for inspectors to swiftly prepare samples and conduct tests with high precision [6][7][8][9], necessitating more efficient sample pre-treatment methods to fulfill these detection requirements.…”

Section: Introductionmentioning

confidence: 99%

Magnetic molecularly imprinted polymer based on coordination for the determination of trace banned substance furosemide in human urine

He,

Chen,

Chen

et al. 2024

J of Separation Science

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Furosemide (FUR), banned in sports events by the World Anti‐Doping Agency, is a key target in drug tests, necessitating a pretreatment material capable of selectively, rapidly, and sufficiently separating/enriching analytes from complex matrices. Herein, a metal‐mediated magnetic molecularly imprinted polymer (mMIP) was rationally designed and synthesized for the specific capture of FUR. The preparations involved the utilization of chromium (III) as the binding pivot, (3‐aminopropyl)triethoxysilane as functional monomer, and Fe3O4 as core, all assembled via free radical polymerization. Both the morphologies and adsorptive properties of the mMIP were characterized using multiple methods. The resulting Cr(III)‐mediated mMIP (ChM‐mMIP) presented excellent selectivity and specificity toward FUR. Under optimized conditions, the adsorption capacity reached 128.50 mg/g within 10 min, and the imprinting factor was 10.41. Moreover, it was also successfully applied as a dispersive solid‐phase extraction material, enabling the detection of FUR concentration as low as 20 ng/mL in human urine samples when coupled with a high‐performance liquid chromatography/photodiode array. Overall, this study offers a valuable strategy for the development of novel recognition material.

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Synthesis and characterization of molecularly imprinted polymers for detection of the local anesthetic lidocaine in urine

Cited by 7 publications

References 35 publications

Development of a Potential-Modulated Electrochemiluminescence Measurement System for Selective and Sensitive Determination of the Controlled Drug Codeine

Development of a Potential-Modulated Electrochemiluminescence Measurement System for Selective and Sensitive Determination of the Controlled Drug Codeine

Biodegradable and Sustainable Synthetic Antibodies—A Perspective

Magnetic molecularly imprinted polymer based on coordination for the determination of trace banned substance furosemide in human urine

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