Synthesis and characterization of monodispersed P(St-co-DMAEMA) nanoparticles as pH-sensitive drug delivery system

Hu, Yang; Wang, Jishuai; Hong, Zhang; Jiang, Guoqiang; Kan, Chengyou

doi:10.1016/j.msec.2014.08.061

Cited by 42 publications

(23 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It must be emphasized that the charges of the microparticles became higher when the comonomer contents increased, due to the higher concentration of tertiary amines. Similar results were reported by HU et al when nanoparticles of poly(dimethylaminoethyl styrene‐co‐methacrylate) were synthesized. These results confirmed that the suspension polymerization technique was efficient for manufacture of smart microparticles.…”

Section: Resultssupporting

confidence: 88%

Development of Smart Polymer Microparticles through Suspension Polymerization for Treatment of Schistosomiasis

Paiva

Alves

Melo

et al. 2019

Macro Reaction Engineering

View full text Add to dashboard Cite

Schistosomiasis is a parasitic disease that affects millions of people, especially low‐income people, and is considered a major public health problem in underdeveloped countries. The drug used most often for the treatment of the disease is praziquantel (PZQ), which has a strong and characteristic bitter taste that makes treatment of children inconvenient. For this reason, the present work investigates the development of smart pH‐sensitive polymer microparticles produced through suspension polymerizations to be used as vehicles for the controlled release of praziquantel in the body. The microparticles are produced through copolymerization of methyl methacrylate and the cationic comonomers diethylaminoethyl methacrylate or dimethylaminoethyl methacrylate. The obtained results indicate that microparticles with sizes in the range of 10–1100 µm can be formed successfully, allowing high PZQ encapsulation efficiencies (>80%). Zeta potential analyses and drug release assays confirm the pH‐sensitive responses of the cationic copolymers, leading to effective release of PZQ (around 80% in pH 1.2) in acidic media that simulate the organic fluids present in the stomach.

show abstract

Section: Resultssupporting

confidence: 88%

Development of Smart Polymer Microparticles through Suspension Polymerization for Treatment of Schistosomiasis

Paiva

Alves

Melo

et al. 2019

Macro Reaction Engineering

View full text Add to dashboard Cite

show abstract

“…As raw material for the preparation of porous P(St‐ co ‐DMAEMA) NPs by acid–alkali post‐treatment, solid P(St‐ co ‐DMAEMA) NPs should be first prepared. In our previous work, P(St‐ co ‐DMAEMA) NPs were fabricated by batch emulsion polymerization . It was found that, although the preparation process was simple, the hydrophilic DMAEMA functional monomer units tended to aggregate on the surface of the NPs.…”

Section: Resultsmentioning

confidence: 99%

“…Imitating the method of carboxyl‐containing porous NP preparation, Okubo and colleagues carried out significant preliminary exploration of the preparation of amino‐containing porous NPs by acid–alkali post‐treatment . In our laboratory, we have systematically investigated the preparation of amino‐containing solid NPs, hollow NPs and composite NPs using N , N ′‐dimethylaminoethyl methacrylate (DMAEMA) as functional monomer . In the preparation of hollow NPs, the acid–alkali post‐treatment process was utilized, and the NP morphology significantly depended on the precise control of post‐treatment conditions including temperature, initial pH and time, which made a basis for further study of the preparation of porous NPs.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of porous cationic poly[styrene‐co‐(N,N′‐dimethylaminoethyl methacrylate)] nanoparticles and their adsorption of heavy metal ions in water

Wang

Shen

et al. 2018

Polymer International

Self Cite

View full text Add to dashboard Cite

Using styrene (St) and N,N′‐dimethylaminoethyl methacrylate (DMAEMA) as raw materials, monodispersed P(St‐co‐DMAEMA) nanoparticles (NPs) were first prepared via semi‐continuous emulsion polymerization, and using a stepwise acid–alkali post‐treatment, porous P(St‐co‐DMAEMA) NPs were then obtained and used to adsorb heavy metal ions in aqueous phase. Results showed that the post‐treatment conditions including temperature, initial pH and time of acid–alkali treatment had significant effects on the morphology of the porous P(St‐co‐DMAEMA) NPs, with higher temperature, more extreme pH condition and longer treatment time resulting in larger pores and volume swelling ratio. Under the optimized acid–alkali post‐treatment conditions (60 °C, acid treatment at pH = 4.0 for 1 h and then alkali treatment at pH = 10.0 for 1 h), the obtained porous NPs had nearly 15 times the surface area and 1.5 times the amount of surface amino groups than the corresponding solid NPs. An analysis of the mechanism of metal ion adsorption on the porous NPs indicated that the adsorbed amount of metal ions was the result of synergistic effect of physical and chemical adsorption, which was closely related to the porous NP surface area, amount of surface of amino groups and the volume of the ions. © 2018 Society of Chemical Industry

show abstract

“…In recent years, stimuli-responsive drug delivery systems have attracted a great deal of attention because of their capability to release of drugs in controllable manner in response to environmental changes such as temperature and pH [1][2][3]. pH-sensitive systems are predominantly used due to different pH values in tissues and cellular compartments [4].…”

Section: Introductionmentioning

confidence: 99%

Grafting of pH-sensitive poly (N,N-dimethylaminoethyl methacrylate-co-2-hydroxyethyl methacrylate) onto HNTS via surface-initiated atom transfer radical polymerization for controllable drug release

Noein

Haddadi‐Asl

Salami‐Kalajahi

2016

International Journal of Polymeric Materials and Polymeric Biom

View full text Add to dashboard Cite

Synthesis and characterization of monodispersed P(St-co-DMAEMA) nanoparticles as pH-sensitive drug delivery system

Cited by 42 publications

References 39 publications

Development of Smart Polymer Microparticles through Suspension Polymerization for Treatment of Schistosomiasis

Development of Smart Polymer Microparticles through Suspension Polymerization for Treatment of Schistosomiasis

Preparation and characterization of porous cationic poly[styrene‐co‐(N,N′‐dimethylaminoethyl methacrylate)] nanoparticles and their adsorption of heavy metal ions in water

Grafting of pH-sensitive poly (N,N-dimethylaminoethyl methacrylate-co-2-hydroxyethyl methacrylate) onto HNTS via surface-initiated atom transfer radical polymerization for controllable drug release

Contact Info

Product

Resources

About