Synthesis and characterization of montmorillonite/ciprofloxacin/TiO2 porous structure for controlled drug release of ciprofloxacin tablet with oral administration

Gulen, Buket; Demirçivi, Pelin

doi:10.1016/j.clay.2020.105768

Cited by 22 publications

(13 citation statements)

References 46 publications

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“…The efficient oral administration and subsequent absorption of different bioactive compounds such as drugs, proteins, peptides, hormones, and antibodies by the human body have been widely studied due to various challenges to preserve their functionality and structural integrity as they transit through harsh environments in the gastrointestinal (GI) tract [1][2][3]. Similarly, nutraceuticals, which generally are poorly soluble in water, have low bioavailability by this route of administration [4].…”

Section: Introductionmentioning

confidence: 99%

Gelatin-Graphene Oxide Nanocomposite Hydrogels for Kluyveromyces lactis Encapsulation: Potential Applications in Probiotics and Bioreactor Packings

et al. 2021

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Nutraceutical formulations based on probiotic microorganisms have gained significant attention over the past decade due to their beneficial properties on human health. Yeasts offer some advantages over other probiotic organisms, such as immunomodulatory properties, anticancer effects and effective suppression of pathogens. However, one of the main challenges for their oral administration is ensuring that cell viability remains high enough for a sustained therapeutic effect while avoiding possible substrate inhibition issues as they transit through the gastrointestinal (GI) tract. Here, we propose addressing these issues using a probiotic yeast encapsulation strategy, Kluyveromyces lactis, based on gelatin hydrogels doubly cross-linked with graphene oxide (GO) and glutaraldehyde to form highly resistant nanocomposite encapsulates. GO was selected here as a reinforcement agent due to its unique properties, including superior solubility and dispersibility in water and other solvents, high biocompatibility, antimicrobial activity, and response to electrical fields in its reduced form. Finally, GO has been reported to enhance the mechanical properties of several materials, including natural and synthetic polymers and ceramics. The synthesized GO-gelatin nanocomposite hydrogels were characterized in morphological, swelling, mechanical, thermal, and rheological properties and their ability to maintain probiotic cell viability. The obtained nanocomposites exhibited larger pore sizes for successful cell entrapment and proliferation, tunable degradation rates, pH-dependent swelling ratio, and higher mechanical stability and integrity in simulated GI media and during bioreactor operation. These results encourage us to consider the application of the obtained nanocomposites to not only formulate high-performance nutraceuticals but to extend it to tissue engineering, bioadhesives, smart coatings, controlled release systems, and bioproduction of highly added value metabolites.

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Section: Introductionmentioning

confidence: 99%

Gelatin-Graphene Oxide Nanocomposite Hydrogels for Kluyveromyces lactis Encapsulation: Potential Applications in Probiotics and Bioreactor Packings

et al. 2021

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“…Furthermore, HNTs-Ht nanomaterial could be an alternative system for the simultaneous co-delivery of different antibacterial agents for the treatment of different patologies. It, indeed presents similar adsorption behavior of other systems commonly used, such as bentonite, fluorohectorite, montmorillonite, and hydroxyapatite, for the delivery of ciprofloxacin and silver ions [ 27 , 28 , 29 , 30 , 31 ].…”

Section: Discussionmentioning

confidence: 68%

Synthesis and Characterization of Nanomaterial Based on Halloysite and Hectorite Clay Minerals Covalently Bridged

et al. 2021

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Halloysite is an aluminosilicate clay with a predominantly hollow tubular structure (HNTs) able to act as a nanocontainer for the encapsulation of several chemicals. However, HNTs possess low affinity for metal ions in their pristine form and they need to be modified for improving their adsorption capabilities. Therefore, to overcome this issue herein we report a straightforward approach for the covalent modification of the external surface of halloysite nanotubes with hectorite clay. Compared to halloysite, hectorite possesses a lamellar structure with higher cation exchange capacity. The covalent linkage between the two clays was verified by several techniques (FTIR spectroscopy, 13C CP-MAS NMR, TGA, ζ-potential, DLS, and XRD measurements) and the morphology was imaged by TEM investigations. As proof of concept the adsorption ability of the obtained nanomaterial in comparison to pristine clays was proved using ciprofloxacin and silver ions chosen as models for their different chemical characteristics.

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“…However, the regression results with Korsemeyer-Peppas shows good correlation where for the n > 1 obtained under the static state indicates super case II transport, which describe the rapid increase in the absorption of the solution in the polymer where it results in the forces exerted by the material with the swelling property [46]. Moreover, the value n = 0.73 for the 10% of the drug at continuous state shows the degradation of the polymer film during the release period, where it seems that integrating the erosion has intensified the kinetic of the degradation.…”

Section: Drug Release Results and Mechanismsmentioning

confidence: 90%

On the importance of physical and mechanical properties of PLGA films during drug release

Abbasnezhad

Zirak

Shirinbayan

et al. 2021

Journal of Drug Delivery Science and Technology

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Synthesis and characterization of montmorillonite/ciprofloxacin/TiO2 porous structure for controlled drug release of ciprofloxacin tablet with oral administration

Cited by 22 publications

References 46 publications

Gelatin-Graphene Oxide Nanocomposite Hydrogels for Kluyveromyces lactis Encapsulation: Potential Applications in Probiotics and Bioreactor Packings

Gelatin-Graphene Oxide Nanocomposite Hydrogels for Kluyveromyces lactis Encapsulation: Potential Applications in Probiotics and Bioreactor Packings

Synthesis and Characterization of Nanomaterial Based on Halloysite and Hectorite Clay Minerals Covalently Bridged

On the importance of physical and mechanical properties of PLGA films during drug release

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