Synthesis and characterization of multifunctional hyperbranched polyesters as prospective contrast agents for targeted MRI

Sideratou, Zili; Tsiourvas, Dimitris; Theodossiou, Theodossis A.; Fardis, M.; Paleos, Constantinos M.

doi:10.1016/j.bmcl.2010.05.055

Cited by 26 publications

(15 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Given these beneficial properties, HBPDCs are excellent candidates for high drug-loading nanomedicine fabrication. [151][152][153] Prabaharan et al 154 synthesized the first HBPDC nanomedicines in 2009. In their work, a folate-targeting unimolecular micelle nanomedicine was synthesized, namely Boltorn H40-poly(l-aspartate-doxorubicin)-b-PEG/FA-conjugated PEG (H40-P[LA-Dox]-b-PEG-OH/FA).…”

Section: Branched Polymer-drug Conjugatesmentioning

confidence: 99%

High drug-loading nanomedicines: progress, current status, and prospects

Shen

Liu

et al. 2017

IJN

438

268

View full text Add to dashboard Cite

Drug molecules transformed into nanoparticles or endowed with nanostructures with or without the aid of carrier materials are referred to as “nanomedicines” and can overcome some inherent drawbacks of free drugs, such as poor water solubility, high drug dosage, and short drug half-life in vivo. However, most of the existing nanomedicines possess the drawback of low drug-loading (generally less than 10%) associated with more carrier materials. For intravenous administration, the extensive use of carrier materials might cause systemic toxicity and impose an extra burden of degradation, metabolism, and excretion of the materials for patients. Therefore, on the premise of guaranteeing therapeutic effect and function, reducing or avoiding the use of carrier materials is a promising alternative approach to solve these problems. Recently, high drug-loading nanomedicines, which have a drug-loading content higher than 10%, are attracting increasing interest. According to the fabrication strategies of nanomedicines, high drug-loading nanomedicines are divided into four main classes: nanomedicines with inert porous material as carrier, nanomedicines with drug as part of carrier, carrier-free nanomedicines, and nanomedicines following niche and complex strategies. To date, most of the existing high drug-loading nanomedicines belong to the first class, and few research studies have focused on other classes. In this review, we investigate the research status of high drug-loading nanomedicines and discuss the features of their fabrication strategies and optimum proposal in detail. We also point out deficiencies and developing direction of high drug-loading nanomedicines. We envision that high drug-loading nanomedicines will occupy an important position in the field of drug-delivery systems, and hope that novel perspectives will be proposed for the development of high drug-loading nanomedicines.

show abstract

Section: Branched Polymer-drug Conjugatesmentioning

confidence: 99%

High drug-loading nanomedicines: progress, current status, and prospects

Shen

Liu

et al. 2017

IJN

438

268

View full text Add to dashboard Cite

show abstract

“…The phase transition was obtained at pH 6.5 for the polymer containing cisplatin and this translated to a faster release of cisplatin at such pH compared to pH 7.4. The complex showed antitumor effect similar to free cisplatin meanwhile the control Suc-HPMHO had low cytotoxicity against COS-7 African green monkey kidney fibroblast cells, and self-assembled into NPs of Sideratou et al 122 reported the conjugation of Gd chelating moieties and FA targeting ligands to Boltorn® H40 HB polyesters. They introduced EDTA (ethylenediaminetetraacetic acid) and DTDA (diethylenetriaminepentaaceticacid) groups on the surface of two different HBPs and covered them with PEG chains (average of 3 PEG/polymer).…”

Section: Please Do Not Adjust Marginsmentioning

confidence: 99%

Smart branched polymer drug conjugates as nano-sized drug delivery systems

2015

View full text Add to dashboard Cite

show abstract

“…It has been reported in the literature that MRI polyester imaging agents provide efficient contrast enhancement compared to other strategies in vitro and in vivo. Recently, several pioneering reports containing polyesters, conjugated or decorated with MRI contrast agents, have been found in the literature …”

Section: Polyesters With Imaging Contrast Propertiesmentioning

confidence: 99%

Recent Advances in Polyesters for Biomedical Imaging

Attia

Brummel

Lex

et al. 2018

Adv Healthcare Materials

View full text Add to dashboard Cite

Several synthetic materials exhibiting contrast imaging properties have become vital to the field of biomedical imaging. Polymeric biomaterials and metals are commonly used imaging agents and can assist in the monitoring of therapy response, migration, degradation, changes in morphology, defects, and image-guided surgery. In comparison to metals, most bio and synthetic polymers lack inherent imaging properties. Polymeric biomaterials, specifically polyesters, have gained a considerable amount of attention due to their unique properties including biocompatibility, biodegradation, facile synthesis, and modification capability. Polyester implants and nanomaterials are available on the market or are in clinical trials for many applications including: dental implants, cranio-maxilofacial implants, soft tissue sutures and staples, abdominal wall repair, tendon and ligament reconstruction, fracture fixation devices, and coronary drug eluting stents. This review aims to provide a summary of the recent developments of polyesters with bioimaging contrast properties. The three main approaches to prepare bioimaging polyesters (coating, encapsulation, and functionalization) are discussed in depth. Furthermore, commonly used imaging modalities including X-ray computed tomography, magnetic resonance imaging, ultrasound, fluorescence, and radionucleotide polyester contrast agents are highlighted. In each section, examples of impactful bioimaging polyesters in the five major imaging modalities are evaluated.

show abstract

Synthesis and characterization of multifunctional hyperbranched polyesters as prospective contrast agents for targeted MRI

Cited by 26 publications

References 38 publications

High drug-loading nanomedicines: progress, current status, and prospects

High drug-loading nanomedicines: progress, current status, and prospects

Smart branched polymer drug conjugates as nano-sized drug delivery systems

Recent Advances in Polyesters for Biomedical Imaging

Contact Info

Product

Resources

About